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Design, Synthesis and Anticancer Evaluation of Chalcone-thiazolidinone HybridsBy Ruchika Goyal, A. Kumar, S. Kumar
Abstract: A small series of chalcone-thiazolidinone hybrids has been designed, synthesized in good yield and evaluated for anticancer activity on the three cell lines A-549, U-87 and COLO-205. All the compounds showed significant cytotoxic effect in micromolar range on the three cell lines. Compounds CT8 and CT6 were found to be the most potent on A-549 and COLO-205 (IC50 = 38.89 µM and 52.23 µM), respectively. Keywords: Chalcone-thiazolidinone, cytotoxic, anticancer activityCite …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 23–30 Read article →