Research & Reviews: A Journal of Drug Design & Discovery
Volume 3, Issue 2 (2016)
Published
Table of contents
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2D QSAR Studies on Some Novel 17a-aza-D-Homo Steroids as 5α-Reductase Inhibitors
Abstract: The major circulating hormone dihydrotestosterone (DHT) is responsible for the development and progression of benign prostate hyperplasia (BPH). Dihydrotestosterone (DHT) is by produced by NADPH dependent reduction of testosterone (T) under the catalytic effect of the enzyme 5α-reductase (5 alpha R). Inhibition of 5α-reductase enzyme is the novel approach for treatment of BPH. Present work describes relationship between the 5α-reductase inhibitory activity for structurally related amides and esters of 17a-Aza-D-Homo-17-one …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 1–14 Read article
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A Review on Herbal Drugs as an Analgesic
Abstract: Any group of drugs of diverse chemical structure and physiological effects which are commonly used for the relief of pain is referred to as analgesics. To qualify as an analgesic, a drug must selectively reduce or abolish pain without causing impairment of consciousness, mental confusion, in coordination or paralysis, or other derangements of the nervous system. Opium is the best-known class of narcotic alkaloid analgesics, a drug obtained by extracting …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 15–22 Read article
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Design, Synthesis and Anticancer Evaluation of Chalcone-thiazolidinone Hybrids
Abstract: A small series of chalcone-thiazolidinone hybrids has been designed, synthesized in good yield and evaluated for anticancer activity on the three cell lines A-549, U-87 and COLO-205. All the compounds showed significant cytotoxic effect in micromolar range on the three cell lines. Compounds CT8 and CT6 were found to be the most potent on A-549 and COLO-205 (IC50 = 38.89 µM and 52.23 µM), respectively. Keywords: Chalcone-thiazolidinone, cytotoxic, anticancer activityCite …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 23–30 Read article
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Effect of Polyherbal Compound (Low Cost) in Management of Insulin Dependent Diabetes Mellitus
Abstract: Diabetes mellitus is chronic ailment associated with life threating target organ damage. The present approach of treatment is to maintain glycaemic level within physiological normal level with different means, which may favour angiopathic changes even with normal blood sugar. Ayurveda believes that Medas i.e. lipid metabolism is important pathological change observed in DM that ends up presentation of elevated level of peripheral blood sugar. The quest is to come with …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 31–34 Read article
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Recent Trends in Drug Repositioning for Discovery of New Anticancer Drugs
Abstract: Drug repositioning, the process of finding new uses of existing drugs, has been gaining popularity in recent years. The availability of several established clinical drug libraries and rapid advances in disease biology, genomics and bioinformatics has accelerated the pace of both activity-based and in silico drug repositioning. Drug repositioning has attracted particular attention from the communities engaged in anticancer drug discovery due to the combination of great demand for new …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 35–38 Read article