Research & Reviews: A Journal of Drug Design & Discovery
Volume 5, Issue 1 (2018)
Published
Table of contents
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2D-QSAR (Quantitative Structure Activity Relationship) Study of Probable Inhibitors for Oral and Cervical Cancers, Generation of Model for Pharmacophore Prediction
Abstract: Twenty-four analogs, conjugates and congeners of curcumin reported as inhibitors against HPV 16 E6 and E7 protein targets have been selected for generating QSAR model. The 46 descriptors were calculated using Schrodinger program version quikprop 9.2. Two alternative methods have been used to generate QSAR models. The first model generation was built on 5 descriptors namely glob, QPlogS, CIQPlogS, IP (eV), human oral absorption which were subjected to multiple linear …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 1–13 Read article
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Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
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Hepatoprotective Role of Exogenous Melatonin and Insulin Plant (Costus IgneousNak.) Extract against the Streptozotocin Induced Diabetes in Rats
Abstract: The aim of the present study was to compare hepatoprotective efficacy of exogenous melatonin and insulin plant extract against streptozotocin induced hepatic complications. To induce diabetes adult female rat were administrated with STZ (15mg/kg) for consecutive six days. The confirmation of diabetic model was analyzed by blood glucose test. Following confirmation diabetic rat model were treated with exogenous MEL intraperitoneally and plant extract was administered orally. Administration of MEL and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 25–36 Read article
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The Research Outline for Performing in vitro Cataract Research on Goat Eyes
Abstract: Cataract could be defined as opacification of the lens. It is one the most common complications related with growing age, diabetes, hypertension, nicotine consumption, alcohol abuse and sedentary life style. The current approach in management of cataract is the surgical removal of the cataract, but there are certain complications that arises pre-operatively, post operatively and during the surgical phase, that’s why there is a dire need in development of a …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 37–39 Read article
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Natural Bio-Potentiator: An Overview
Abstract: In down of recent civilization, the increased cost of medicines is the major issues of concern. To reduce the cost of demand, one of the ayurvedic method being established is a bioenhancer, an agent which combines with certain drugs or nutrient and increases their efficiency of work without any typical pharmacological activity of its own at the dose used. Since being herbal in origin, its risk of side effects was …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 40–42 Read article