Research & Reviews: A Journal of Drug Design & Discovery
Volume 5, Issue 3 (2018)
Published
Table of contents
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3D-QSAR Studies on Protein Phosphatase 2A Inhibitors as Anti-cancer Agents
Abstract: The tremendous efforts by researcher indicates that cantharidin, nor cantharidin and their analogues shows anti-cancer activity due to their inhibition of cancer cell lines such as HT29, SW480, MCF-7, A2780, H460, A431, DU145 and L1210. The anti-cancer activities of cantharidin, nor cantharidin and their analogues involve the inhibition of serine/threonine protein phosphatises (PPs) activity. In this study, three-dimensional quantitative structure activity relationship (3D-QSAR) like comparative molecular field analysis (CoMFA), and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 1–19 Read article
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Exploring Molecular Structural Requirement of Acetylcholinesterase Inhibitors Using Molecular Docking Study
Abstract: To explore the molecular structure requirement of acetyl-cholinesterase inhibitors, we used some flavonoid derivatives and calculated its binding interaction with acetylcholinesterase enzyme using 1EVE PDB. Flavonoids are one of the largest class and plant secondary metabolites known to have variety of biological activity for human wellbeing. Also reported its acetylcholinesterase inhibitory potency by various researchers. To know the properties and selection of flavonoids, we were used databases through Google Scholar, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 20–34 Read article
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HDAC and HDAC Inhibitors: Implication in Different Pathological Ailments
Abstract: Histone deacetylases (HDAC) and its inhibitors have been found implicated in various diseased conditions. HDACs regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. They have also been found to regulate the post translational modifications through deacetylation of proteins, and hence are involved in many pathophysiological conditions. Till date, USFDA has approved vorinostat, romidepsin, panobinostat, and belinostat as HDAC inhibitors for the treatment of cancer. Considering their wide …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 35–40 Read article
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In Silico Study on Estrogens Receptor Modulators as Anti-cancer Agents
Abstract: The clinical selective estrogen receptor modulator tamoxifen is most commonly used drug for the treatment of estrogen positive breast cancer and has been preventing lives worldwide. The pioneering drug; tamoxifen used in both treatment and prevention of estrogen positive breast cancer and also addressing new research for selective estrogen receptor modulators (SERMs). Based on these for current study 20 tamoxifen derivatives has been designed for in silico study. For the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 41–54 Read article
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Quantitative Estimation of the Total Flavonoid Contents of Anogeissus pendula Stem
Abstract: Flavonoids are the typical secondary metabolites contents which are very useful in the plants as well as for human beings. They are one of the sources of several kinds of biological activity in the stem as well as in other part of the plants. These flavonoids are the typical antioxidants as well as they are used in inflammation; they are the typical antimicrobial, they have well distribution in the whole …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 55–57 Read article