Research & Reviews: A Journal of Drug Design & Discovery
Volume 4, Issue 3 (2017)
Published
Table of contents
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In silico potential drug target identification against 4-aminobutyrate aminotransferase for Huntington diseases
Abstract: Huntington disease, HD is a progressive neurodegenerative disorder. Some excitatory chemicals released like glutamate which causes the cell damage and the neuron die due to over accumulation of the glutamate in Huntington diseases (HD), which is regulated by the GABA also known as gamma- amino butyric acid, it is a major inhibitory neurotransmitter of the nervous system. Here we are targeting the pyridoxal dependent enzyme which degrades the GABA neurotransmitter, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 1–5 Read article
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Evidence for the Superior Quality and Efficacy of Dr. JRK’s 777 Oil
Abstract: The use of several oil preparations in ancient system of medicine such as, Ayurveda and Siddha for the treatment of various ailments are well known and the method of preparation of thailam do affect the acid value of the oils and make them harmful to the patients. The present paper reports the outstanding precaution and exemplary technological standardization adopted in the preparation of Dr. JRK’s 777 oil and how to …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 19–21 Read article
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Synthesis and Antimicrobial Evaluation of Novel Benzimidazolyl Chalcones
Abstract: A new synthesis of benzimidazolyl chalcones derivatives of N1-[4-(1H-benzo[d]imidazol-2-yl) phenyl] derivatives were synthesized. These compounds have been characterized by detailed IR and NMR spectral analysis and have been screened for their antimicrobial activity in-vitro against bacterial Strains of Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, and Bacillus subtelis, and fungal strains of Aspergillus niger and Candida albicans were used. Most of the tested compounds exploited potent antimicrobial activity with …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 22–29 Read article
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Study of Anti-Leishmanial Activities of Metabolites on Leishmania major: A Structure-Based Drug Designing Approach
Abstract: Cutaneous Leishmaniasis is one of the major problem all over the world and has no suitable treatment to treat this disease. However, the range of drugs is limited and increased use of these drugs lead to multiple drug resistance and has posed a major concern. Here the genome sequences of Leishmania major (responsible for cutaneous Leishmaniasis) is identified for having few drug targets that are unique to these parasites. GPI …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 30–40 Read article
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ABCB5 and β catenin activity for colon cancer: A review
Abstract: Colorectal malignancy (CRC) is the second most regularly analyzed disease among females and third among guys around the world. It likewise contributes fundamentally to growth related passing, regardless of the ceaseless advance in symptomatic and helpful techniques. Biomarkers as of now assume an imperative part in the recognition and treatment of patients with colorectal disease. This review gives an avant-garde synopsis on markers such as ABCB5 and β-catenin associated with …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 6–18 Read article