Research & Reviews: A Journal of Drug Design & Discovery
Volume 4, Issue 1 (2017)
Published
Table of contents
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Prodrugs and Its Types
Abstract: In this study, description of prodrugs is given. Prodrugs are biologically inactive agents that upon biotransformation in vivo result in active drug molecules. Inactive prodrugs are pharmacologically inactive medications that are metabolized into an active form within the body. Depending upon the functional group, used to design the produrg, present in the parent drug, the pro drugs can be classified so many ways, which are given in this study. Keywords: …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 1–8 Read article
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Molecular Docking Study of Curcumin-Sugar Conjugates as Cholesterol Biosynthesis as well as Staphylococcus Aureus Virulence Inhibitor
Abstract: Methicillin resistant Staphylococcus Aureus infections are the major concern in both, communities as well as in clinics. Presqualene diphosphate is the key molecule obtained from farnesyl diphosphate for the biosynthesis of staphylophyloxanthin which is responsible for the virulence of Staphylococcus Aureus as well as for cholesterol biosynthesis in humans. We designed some natural curcumin-sugar conjugates that binds to the protein associated with the formation of presqualene diphosphate and inhibit it, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 15–21 Read article
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New Drug Approvals and Prohibition during the Mid-Year of 2016
Abstract: Every day drugs are being approved by various drug controlling authorities, for treating ailments and for improvising health care. USFDA, CDER and CDSCO (Central Drugs Standard Control Organization) play major role in controlling the drug usage in India, to ensure the safety and efficacy of the treatments. In India most of the OTC products has been banned and this review helps in simplifying the list of the drugs banned and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 22–25 Read article
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2D-QSAR Studies on Unsaturated 4-Azasteroids as 5α-reductase Inhibitors
Abstract: Dihydrotestosterone (DHT) a major circulating male hormone is produced by NADPH dependent enzyme 5α-reductase (5 alpha R) and has been found to be causative agent in the development of pathological condition i.e. benign prostate hyperplasia (BPH). Thus inhibition of 5α-reductase enzyme represents a novel target in the treatment of BPH. Present study describes the relationship between the 5α-Reductase inhibitory activity for structurally related unsaturated 4-azasteroids derivatives and their physicochemical descriptors …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 26–37 Read article
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A Case Study of Laryngeal Narrowing with Glossopharyngeal Neuritis in Insulin Dependent Diabetes Patient
Abstract: Neuritis is a very common complication met in with chronic diabetics. Commonly, peripheral nerves are involved but involvement of cranial nerves is not a common phenomenon. Involvement of cranial nerves or autonomic nerves may produce serious medical emergency that requires prompt management for life saving followed by long term control management. Such a case of insulin dependent diabetes mellitus with laryngeal narrowing and glossopharyngeal neuritis was met in a clinical …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 9–14 Read article