Research & Reviews: A Journal of Drug Design & Discovery
Volume 5, Issue 2 (2018)
Published
Table of contents
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Assessment and In Vitro Studies of Potent Amylase Inhibitor from Different Plant Species
Abstract: Flavonoids are naturally occurring compounds widely distributed in plants, which have hypoglycemic potential. Amylase inhibitors belong to flavonoids that block amylases which are involved in hydrolyzing the carbohydrates to yield low molecular weight dextrin and sugars. Inhibition of α-amylase along with α-glucosidase can significantly reduce the post-prandial increase of blood glucose and can be an important strategy in the control of blood glucose level in the type-2 diabetic patients. In …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 1–6 Read article
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Study of Price Variation of Anti-infective Eye Preparations
Abstract: To analyze the percentage cost variations among different brands of commonly prescribed ophthalmic drugs. The cost of different brands of commonly used ophthalmic drugs was sorted out by referring the latest Current Index of Medical Specialities, Indian Drug Review and Retail drug store. The cost of five dosage forms in INR of each brand, cost ratio and percentage cost variation ware calculated. Our study findings showed a very high fluctuation …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 10–12 Read article
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In Silico Induced-Fit Molecular Docking and Pharmacokinetic Investigations of Pentacyclic Compounds as Promising Inhibitors of Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX)
Abstract: The current search involves the discovery of cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) inhibitory potentials of some pentacyclic macromolecules by employing the Maestro 9.1 software where Glide module was utilized for the induced-fit docking (IFD). In addition to it, the critical pharmacokinetic aspects such as QPPMDCK, QPlogPo/w, % human oral absorption, QPPCaco, and QPlogS were estimated. The study fruitfully opened the therapeutic pharmacodynamic perspectives and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 13–17 Read article
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Current Prospective of NLCs in Parkinson’s Disease: An Outlook
Abstract: Parkinson's disease (PD) is 2nd most a neuro-degenerative disorder of the central nervous system affecting 7–10 million people of worldwide as the report of WHO 2014. It occurs due to the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. It is characterized by tremor, rigidity, bradykinesia, dementia, depression and falls or emerges with the progression of the disease. Ropinirole Hydrochloride is a drug of choice …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 18–29 Read article
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Bacterial DNA Gyrase (Topoisomerase) Inhibitory Potentials of Heterocyclic Natural Products: Investigations through Induced-Fit Molecular Docking Approach
Abstract: The study exclusively focuses on the exploration towards the hidden potential of heterocyclic natural products against bacterial DNA gyrase (topoisomerase) through induced-fit docking (IFD) by utilizing the Glide module of Maestro 9.1 software. The study will open new doors for the antibacterial drug discovery by the inhibition of imperative biological target. Keywords: antibacterial, DNA gyrase, heterocyclic compound, molecular docking, natural product, topoisomeraseCite this ArticleTomy Muringayil Joseph, Debarshi Kar Mahapatra. Bacterial …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 7–9 Read article