13 publications
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Published Subscription Review Article
Exploring Phytomedicine: Innovations, Efficacy and Future DirectionsBy Mohd. Wasiullah, Piyush Yadav, Satish Kumar Yadav, Rehan Ahmed Khan
Abstract: The use of plant-derived substances for therapeutic purposes has long been a cornerstone of traditional medicine systems worldwide. With increasing interest in natural remedies, the field of phytomedicine is experiencing a revival, marked by innovations in research, formulation, and application. This review article explores recent advancements in phytomedicine, highlighting novel extraction technologies, and the efficacy of plant-based treatments in clinical settings. The review also addresses the challenges faced in phytomedicine …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 2, 2025 · pp. 32–50 Read article →
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Published Subscription Review Article
A Review of Drug Design Techniques Assisted by Computers to Combat DiabetesBy Mohd. Wasiullah, Piyush Yadav, Neeraj Maurya, Satish Kumar Yadav, Akash Mishra
Abstract: Diabetes mellitus is a global health concern characterized by chronic hyperglycemia and associated complications. The creation of innovative medicines with enhanced efficacy and safety profiles continues to be a top focus, notwithstanding improvements in treatment. A useful method in drug development, computer-aided drug design (CADD) makes it easier to identify possible therapeutic candidates and optimise lead molecules. An extensive synopsis of CADD tactics used in the fight against diabetes is …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article →
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Published Subscription Review Article
Review on Computer-Aided Drug Design in RAS Inhibitor DiscoveryBy Mohd. Wasiullah, Piyush Yadav, Alqama Zehra, Satish Kumar Yadav, Sushil Yadav
Abstract: This review explores the utilization of computer-aided drug design (CADD) methodologies in the discovery of inhibitors targeting the RAS pathway, a pivotal signaling cascade implicated in various cancers. Through an extensive examination of computational tools, methodologies, challenges, and recent advancements, this review aims to provide insights into the role of CADD in accelerating RAS inhibitor discovery. The discovery of effective inhibitors targeting the RAS pathway is of paramount importance in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 7–14 Read article →
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Published Subscription Review Article
Modern Computer-aided Drug Design Methods: A ReviewBy Mohd. Wasiullah, Piyush Yadav, Anand Prakash, Satish Kumar Yadav, Mr. Sushil Yadav
Abstract: Computer-aided drug design (CADD) has emerged as a crucial tool in the drug discovery process, offering a time-efficient and cost-effective approach to identifying potential drug candidates. This review aims to provide an overview of modern CADD methods, including high-throughput screening (HTS), structure-based drug design (SBDD), ligand-based drug design (LBDD), structure-based virtual screening (SBVS), and ligand-based virtual screening (LBVS). We discuss the basic principles, applicability, and limitations of each method, highlighting …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 2, 2024 · pp. 14–20 Read article →
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Published Subscription Review Article
Quantitative Structure-activity Relationship in Computer-aided Drug Design: A ReviewBy Satish Kumar Yadav, Manyta Yadav, Mohd. Wasiullah, Piyush Yadav, Priyanshu Upadhyay
Abstract: Quantitative Structure-Activity Relationship stands at the forefront of Computer-Aided Drug Design, providing a systematic framework for understanding the relationship between the chemical structure of molecules and their biological activity. The present review delves into the multifaceted realm of quantitative structure-activity relationship methodologies within the landscape of drug discovery. Through an exploration of diverse quantitative structure-activity relationship models, molecular descriptors, validation techniques, and recent advancements, the present article aims to elucidate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 55–63 Read article →
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Published Subscription Review Article
Ligand Based Drug Virtual Screening in Computer Aided Drug Design: A ReviewBy Satish Kumar Yadav, Vikash Yadav, Mohd. Wasiullah, Piyush Yadav, Mohammad Adham
Abstract: Computer-Aided Drug Design (CADD) has revolutionized the drug discovery process by providing efficient and cost-effective methods for identifying potential drug candidates. Within CADD, ligandbased virtual screening techniques play a pivotal role in the early stages of drug discovery. This review provides a comprehensive overview of ligand-based drug virtual screening, focusing on its principles, applications, challenges, and future directions. Fundamentals of ligand-based virtual screening, including pharmacophore-based methods, similarity searching, and machine …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 1–8 Read article →
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Published Ahead of print Subscription Review Article
A Review on Anesthetic Drug Discovery with Computer Aided Drug DesignBy Satish Kumar Yadav, Mohd. Wasiullah, Piyush Yadav, Ankit Maurya, Mr. Sushil Yadav
Abstract: In contemporary medicine, anaesthesia is essential for enabling surgical procedures, pain control, and patient comfort. Finding and creating safe and efficient anaesthetics is crucial to enhancing patient outcomes and developing the medical field. In this review, we provide a comprehensive overview of anesthetic drug discovery with a focus on the integration of computer-aided drug design (CADD) methodologies. Beginning with an exploration of anesthesia mechanisms and targets, we delve into the …
Published in International Journal of Antibiotics Read article →
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Published Subscription Review Article
An Extensive Analysis of Computer-Aided Drug Design for Novel Psychotropic and Neurological SubstancesBy Satish Kumar Yadav, Mohd. Wasiullah, Piyush Yadav, Safiya Sajid, Ms. Anjali Maurya
Abstract: A comprehensive review of the use of computer-aided drug design (CADD) in the creation of innovative neurologic and neuropsychiatric medications is given in this article. It discusses the challenges in traditional drug discovery approaches and highlights the role of computational methods in accelerating the identification and optimization of drug candidates targeting psychiatric and neurological disorders. The method of finding new drugs has been completely transformed by Computer-Aided Drug Design (CADD), …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 19–27 Read article →
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Published Subscription Review Article
Computer-aided Drug Design Method for Anti-hepatitis C Drug DesignBy Mohd Wasiullah, Piyush Yadav, Tabish Ansari, Satish Kumar Yadav, GrijeshYadav
Abstract: Hepatitis C is a disease caused by the hepatitis C virus and can cause serious liver damage. There is currently no vaccine for this disease and the number of infections continues to increase worldwide. Currently used antiviral drugs are interferon alfa-2a and ribavirin, but about half of patients do not respond to therapy. Therefore, new drugs that protect against hepatitis C need to be investigated. Computational drug methods have been …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 1–8 Read article →
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Published Subscription Review Article
Analysis of Bioinformatics Software Applied in Computer-Aided Drug DesignBy Satish Kumar Yadav, Mohd. Wasiullah, Piyush Yadav, Vinay Kumar Deepak, Divyansh Singh
Abstract: The integration of bioinformatic tools with computational methods has revolutionized the field of Computer-aided Drug Design (CADD), enabling researchers to expedite the discovery and optimization of new therapeutics. This review provides an in-depth analysis of the bioinformatic tools utilized in CADD, encompassing molecular docking, molecular dynamics simulation, virtual screening, homology modelling, and molecular visualization. We go over the tenets, approaches, and uses of these instruments, emphasizing their value in expediting …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 1–10 Read article →
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Published Subscription Review Article
Computer Aided Drug Designing for Targeted Drug Delivery SystemsBy Satish Kumar Yadav, Mohd Wasiullah, Piyush Yadav, Shreya Sahu, Akash Mishra
Abstract: The discovery and development of a contemporary sedate is widely acknowledged as an extremely difficult task that requires significant resources and effort. Therefore, computer-aided medication design techniques are widely utilized today to increase the productivity of the drug discovery and development process. Among structure-based and ligand-based drug design approaches, both recognized for their efficiency in drug discovery and development, various CADD (Computer-Aided Drug Design) techniques are evaluated based on specific …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 34–41 Read article →
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Published Subscription Review Article
Unveiling the Role of Lead Molecules in CADD: A Systematic ReviewBy Mohd Wasiullah, Piyush Yadav, Pramod Yadav, Satish Kumar Yadav, Manyata Yadav
Abstract: The word "medicate plan" alludes to the objective creation of modern drugs. Arbitrary screening of engineered compounds, engineered of organically dynamic compounds based on actually happening drugs, amalgamation of basic analogs of actually happening lead particles, and usage of the bioisosteric hypothesis are a few of the strategies that have been utilized. As a result, the most recent drift in medicate plan is to either completely enhance a lead or …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article →
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Published Subscription Review Article
Advancements in Drug Design Technology and Its Impact on COVID-19 TreatmentBy Mohd. Wasiullah, Piyush Yadav, Raj Aryan Prajapati, Satish Kumar Yadav, Neha Parveen
Abstract: The deadly coronavirus disease 19 (COVID-19) pandemic has recently spread, raising concerns about global health. The search for novel therapeutic compounds is made more necessary by the persistent problem of the absence of licensed medications or vaccinations. By saving money and time, computer-aided drug design has sped up the process of finding and developing new drugs. The structured-based and ligand-based drug discovery subcategories of computer-aided drug design (CADD) are the …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 1–15 Read article →