extrusion-spheronization
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Fabrication and Characterization of Sustained Release Beads of Carbamazepine by Extrusion – Spheronization Containing Carbopol®974
Abstract: The erratic absorption of Carbamazepine, BCS Class II drug, due to low water solubility and anticholinergic properties can be minimized by developing sustained release beads. Sustained release beads of Carbamazepine were prepared using axial single screw extruder and a chequered plate spheronizer. Beads offer therapeutic advantages such as easy dispersion in the gastro-intestinal tract, lower risk of dose dumping, reduce peak plasma fluctuations and drug release is independent of gastric …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 2, 2011 · pp. 11–21 Read article