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3 articles for “extrusion-spheronization”
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Once a Day Pellets of Theophylline by Extrusion Spheronization Technique Using Gelucire® Matrix
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Theophylline, a xanthine bronchodilator has narrow therapeutic index (5 – 15 µg/mL). The aim of the present work was to prepare once a day pellets of theophylline …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 · pp. 36–44 Read article
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Fabrication and Characterization of Sustained Release Beads of Carbamazepine by Extrusion – Spheronization Containing Carbopol®974
Abstract: The erratic absorption of Carbamazepine, BCS Class II drug, due to low water solubility and anticholinergic properties can be minimized by developing sustained release beads. Sustained release beads of Carbamazepine were prepared using axial single screw extruder and a chequered plate spheronizer. Beads offer therapeutic advantages such as easy dispersion in the gastro-intestinal tract, lower risk of dose dumping, reduce peak plasma fluctuations and drug release is independent of gastric …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 2, 2011 · pp. 11–21 Read article
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A Literature Review on Extrusion/Spheronisation-A Pelletization Technology
Abstract: Extrusion-spheronization is a leading pelletization technology, widely favored for its economic and commercial viability. It is a cost-effective method suitable for large-scale production, making it the most efficient approach for oral drug delivery. This process provides multiple benefits, such as improved flow characteristics, lower friability, a narrow particle size range, easier coating, consistent packing, reduced likelihood of dose dumping, and more predictable gastric emptying. Pellets usually measure between 0.5 and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 61–71 Read article