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224 articles for “structural validation”
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Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Influence of Infill Density on Structural Performance of FDM-Processed PET-G Polymer: Experimental Validation through Quadcopter Flight Testing
Abstract: Polyethylene terephthalate glycol-modified (PET-G) is an amorphous thermoplastic copolymer increasingly adopted in structural applications through fused deposition modeling (FDM). However, the correlation between FDM processing parameters, especially infill density, and mechanical performance of PET-G parts remains inadequately characterized under real-life loading conditions. This study investigates how infill density (10% and 30%, grid pattern) influences the structural integrity of FDM-processed PET-G components, validated experimentally through quadcopter airframe fabrication and flight testing. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 644–656 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Physics-Informed Generative and Tensor-Based Framework for DNA Sequence Simulation and Genomic Structure Discovery
Abstract: In this paper, we explore the intersection of artificial intelligence (AI) and mathematical physics to propose advanced methods for DNA sequence generation and analysis. Specifically, we investigate how physics-informed Generative Adversarial Networks (GANs) and tensor network representations can be harnessed to restructure DNA for applications in genetic science. The proposed methodology offers a unique integration of concepts of thermodynamic modeling with innovative GAN architecture in order to allow the creation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Effects of Reels and short videos on human mind and Academic Life
Abstract: The rapid rise of short-form video platforms such as Instagram Reels, TikTok, and YouTube Shorts has fundamentally reshaped the way people consume information and entertainment. While these applications offer quick engagement and social connection, their excessive use has raised serious concerns about their psychological and academic impacts. This research investigates the relationship between short-form video addiction, mindfulness, academic anxiety, and academic engagement among university students. Drawing upon the theoretical framework …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 2, 2026 Read article
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In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
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Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Vaccine Acceptability among Healthcare Workers and Employees of St. Luke’s Medical Center – Quezon City Philippines: A Descriptive Study
Abstract: There are numerous studies and pieces of literature on the growing acceptance and hesitancy in receiving vaccines despite their crucial role in combating epidemics and pandemics. Healthcare workers are frontline workers in public health emergencies; thus, their acceptance of vaccines is critical to mitigating infectious diseases. Nevertheless, while vaccines were known to protect against the virus, vaccine acceptability remains understudied. This study aimed to evaluate the level of vaccine acceptance …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Structural Optimization of FDM-Processed ASA Polymer Frames through Acetone Solvent Welding, Variable Infill Strategy, and Layer Orientation: Experimental Validation via Quadcopter Flight Testing
Abstract: Acrylonitrile styrene acrylate (ASA) is an amorphous terpolymer with superior UV resistance compared to acrylonitrile butadiene styrene (ABS), as its acrylate rubber phase lacks photodegradation-prone carbon–carbon double bonds. This study proposes acetone solvent welding as a polymer joining method to produce monolithic structures from FDM-processed ASA components, addressing three processing challenges: achieving structural continuity through polymer chain interdiffusion at solvent-wetted interfaces, correcting thermal warping via post-print geometric correction during welding, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 689–703 Read article
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Advancements in Metal-Plastic Hybrid Structures: Experimental Analysis and Design Optimization of 3D-Printed Honeycomb Frameworks
Abstract: The exploration of metal-plastic hybrid structures has gained significant attention due to their potential for lightweight, high-strength applications across industries such as aerospace, automotive, and construction. This study investigates the experimental and design enhancements of a metal-plastic hybrid structure utilizing a honeycomb architecture produced through 3D printing. By integrating metals with plastic polymers in a honeycomb configuration, this hybrid approach aims to combine the high strength and stiffness of metals …
Published in Trends in Machine design · Vol. 11, Issue 3, 2024 · pp. 36–43 Read article
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Combustion Synthesis and Comprehensive Characterization of Pure and Ni-Doped CuFe₂O₄ Nanoparticles for Functional Composite Applications
Abstract: The CuFe2-xNixO4 (x = 0, 0.1, 0.3, and 0.5) nanoparticles were synthesized using a combustion method and comprehensively characterized to understand their suitability for polymer-based composite applications. X-ray diffraction confirmed the formation of a single-phase spinel ferrite structure with crystallite sizes of 20–30 nm. Energy-dispersive X-ray spectroscopy verified the successful incorporation of Ni ions into the CuFe₂O₄ lattice, while FE-SEM analysis revealed uniformly dispersed nanoscale particles desirable for composite reinforcement. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1–11 Read article
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Data Structure Driven Probabilistic Deadlock Resolution in Multiprocessor Systems
Abstract: Deadlock resolution in multiprocessor systems is fundamentally a graph-theoretic and probabilistic decision problem. Existing victim selection heuristics, such as youngest, oldest, and lowest priority, apply static rules that overlook the dynamic runtime state of processes, leading to unnecessary computational loss. This paper reframes the inference-guided preemption (IGP) algorithm as a data-structure-centric solution, highlighting how resource allocation graphs, wait-for graphs, adjacency lists, min-heaps, and hash-based evidence stores interact to enable efficient …
Published in International Journal of Data Structure Studies · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article
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Free Vibration of Curved Sandwich Beams with Laminated Composite Facings Using Finite Element Method
Abstract: The present work is focussed on the free vibration analyses of singly curved sandwich beams using three-dimensional finite element method in ABAQUS software. Three different layers are considered for soft core and stiff face sheets in ABAQUS solid modelling to accurately represent the effects of transverse shear deformation of sandwich structure. To validate the model, obtained natural frequencies from present model are first compared with the results available in the …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 549–561 Read article
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Lifestyle Factors and Perceptions of Diabetes Among Individuals in North India
Abstract: Background: Diabetes mellitus is influenced by a complex interplay of genetic, environmental, and lifestyle factors. In North India, unique socio-cultural and dietary patterns shape individual behaviors and perceptions toward diabetes. Understanding these lifestyle choices and cultural beliefs is critical for designing interventions that improve adherence to medical treatment and promote healthier outcomes. Methods: A cross-sectional survey was conducted among 1,500 individuals diagnosed with diabetes across selected urban and rural districts …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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Molecular Docking Analysis of Berberis aristata Phytocompounds as Potential Growth Factor Receptor Blockers in Cancer Therapy
Abstract: Middle-aged and older women are susceptible to breast cancer (BC), a potentially fatal condition. When breast cancer is diagnosed, the median age is 62. Breast cancer diagnoses in women under 45 are comparatively uncommon, whereas the bulk of breast cancer diagnoses occur in women 62 and older. Growth factor receptors are interesting therapeutic targets because of their critical role in the pathophysiology of cancer. Vascular endothelial growth factor receptors (VEGFR-2) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article
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Mechanical Performance Assessment of Hybrid FRP Laminates with Carbon Fiber Core Using Experimental and Numerical Approaches
Abstract: The high strength-to-weight ratio, corrosion resistance and design flexibility of Fiber-reinforced polymer (FRP) composites have attracted considerable attention in aerospace, automotive and structural applications. This work presents an experimental and finite element study on the tensile and flexural behavior of epoxy-based hybrid FRP laminates. Five laminate configurations were manufactured, including a unidirectional carbon fiber laminate and four hybrid laminates, Kevlar–Carbon–Kevlar (K/C/K), Glass–Carbon–Glass (G/C/G), Kevlar–Carbon–Glass (K/C/G), and Glass–Carbon–Kevlar (G/C/K). For all …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article