Search
56 articles for “structural validation”
-
Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
-
Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
-
Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
-
Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
-
Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
-
Effects of Reels and short videos on human mind and Academic Life
Abstract: The rapid rise of short-form video platforms such as Instagram Reels, TikTok, and YouTube Shorts has fundamentally reshaped the way people consume information and entertainment. While these applications offer quick engagement and social connection, their excessive use has raised serious concerns about their psychological and academic impacts. This research investigates the relationship between short-form video addiction, mindfulness, academic anxiety, and academic engagement among university students. Drawing upon the theoretical framework …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 2, 2026 Read article
-
In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
-
Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
-
Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
-
Data Structure Driven Probabilistic Deadlock Resolution in Multiprocessor Systems
Abstract: Deadlock resolution in multiprocessor systems is fundamentally a graph-theoretic and probabilistic decision problem. Existing victim selection heuristics, such as youngest, oldest, and lowest priority, apply static rules that overlook the dynamic runtime state of processes, leading to unnecessary computational loss. This paper reframes the inference-guided preemption (IGP) algorithm as a data-structure-centric solution, highlighting how resource allocation graphs, wait-for graphs, adjacency lists, min-heaps, and hash-based evidence stores interact to enable efficient …
Published in International Journal of Data Structure Studies · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article
-
Lifestyle Factors and Perceptions of Diabetes Among Individuals in North India
Abstract: Background: Diabetes mellitus is influenced by a complex interplay of genetic, environmental, and lifestyle factors. In North India, unique socio-cultural and dietary patterns shape individual behaviors and perceptions toward diabetes. Understanding these lifestyle choices and cultural beliefs is critical for designing interventions that improve adherence to medical treatment and promote healthier outcomes. Methods: A cross-sectional survey was conducted among 1,500 individuals diagnosed with diabetes across selected urban and rural districts …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
-
Molecular Docking Analysis of Berberis aristata Phytocompounds as Potential Growth Factor Receptor Blockers in Cancer Therapy
Abstract: Middle-aged and older women are susceptible to breast cancer (BC), a potentially fatal condition. When breast cancer is diagnosed, the median age is 62. Breast cancer diagnoses in women under 45 are comparatively uncommon, whereas the bulk of breast cancer diagnoses occur in women 62 and older. Growth factor receptors are interesting therapeutic targets because of their critical role in the pathophysiology of cancer. Vascular endothelial growth factor receptors (VEGFR-2) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article
-
Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
-
Secured Communication and Image Authentication: Embedding Encrypted Text Files Into Color Digital Images
Abstract: In today's digital landscape, protecting digital assets, particularly images, is paramount. Researchers have developed various techniques to safeguard these assets, emphasizing their protection and integrity. Simultaneously, steganography plays a crucial role in securely communicating confidential messages. This paper focuses on a dual-purpose technique: watermarking color digital images for protection and embedding secret messages through steganography. This fusion of functionalities represents a significant step in comprehensive asset protection and confidential communication …
Published in International Journal of Information Security Engineering · Vol. 2, Issue 1, 2024 · pp. 10–15 Read article
-
Design, Mathematical Modeling, and Dynamic Optimization of a Speed Breaker-Based Vehicular Kinetic Energy Harvester
Abstract: Decentralized energy harvesting methods are becoming more popular due to rapid urbanization and the rising need for sustainable infrastructure. The road-embedded vehicle kinetic energy harvester (VKEH) design, mathematical modelling, and experimental validation are presented in this work. This paper presents the structural engineering, continuum mathematical modeling, and experimental validation of an optimized road-embedded vehicular kinetic energy harvester (VKEH). The mechanism utilizes a spring- loaded, low-friction rack-and-pinion transmission coupled with a …
Published in International Journal of Electrical Power and Machine Systems · Vol. 4, Issue 2, 2026 Read article
-
Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
-
ASSESSING OF FOREST STRUCTURE USING EARTH OBSERVATION DATA: ACASE STUDY IN MUNESSA FOREST, OROMIA REGION, ETHIOPIA
Abstract: Forest structure is essential for estimating forest-related carbon emissions, analyzing forest degradation, and quantifying the effectiveness of forest restoration initiatives. However, forest structure quantification is only limited to the specific area of interest without considering the whole forest coverage. Remote sensing data can easily deliver a large area to assess forest structure. Therefore, this study aims to assess forest structure of Munessa Natural Forest by integrating satellite based light detection …
Published in International Journal of Land Read article
-
A Pre-experimental Evaluation of a Structured Educational Program on Awareness of Mosquito-borne Diseases in Senior Secondary School Students in Punjab
Abstract: Introduction: Mosquitoes constitute the most important single family of insects from the standpoint of human health. They are found all over the world. The four important groups of mosquitoes in India that are related to disease transmission are the Anopheles, Culex, Aedes, and Mansonia. Aims: The aims of the study are to assess the effectiveness of structured teaching program on knowledge regarding mosquito-borne diseases among students of senior secondary schools …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 7–14 Read article
-
DFT/Data Guided Predictive Modelling of Absorption Maxima in the OLED Rubrene Derivatives
Abstract: This study investigates the optical properties of rubrene derivatives to develop an accurate predictive model for absorption maxima using computational chemistry and chemoinformatic techniques. We benchmarked various quantum chemical methods, identifying that the M06-2X/aug-cc-pVDZ method in dichloromethane (DCM) provided the strongest correlation with experimental data. Key molecular descriptors such as band gap, ionization potential, and electrophilicity index were calculated and analyzed using principal component analysis (PCA) to identify significant factors …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 41–56 Read article
-
Presenting the Model and Prioritization of Lean Production Success Drivers (Case study: Iran Khodro Company)
Abstract: The purpose of the current research is to present a model and prioritize the drivers of lean production success (case study: Iran Khodro Company). The statistical population and statistical sample of this study consists of 20 experts (managers) of Iran Khodro production department. In this research, first, the most important key success factors of lean production were determined using the validity technique of the content validity ratio, then the interpretative …
Published in International Journal of Sustainability · Vol. 1, Issue 1, 2024 · pp. 30–42 Read article