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69 articles for “spectrophotometric”
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Titrimetric and Spectrophotometric Assay of Diethylcarbamazine Citrate in Pharmaceuticals using Permanganate as Oxidant
Abstract: Two titrimetric and one spectrophotometric methods are described for the determination of diethylcarbamazine citrate in bulk drug and dosage forms using permanganate as an oxidimetric agent. In method A, the drug solution in H2SO4 is titrated directly at 800C to a pink end point. DEC was treated with a measured excess of standard permanganate in H2SO4 medium, and after a contact time of 5 min, the residual oxidant back titrated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 3, 2016 · pp. 1–11 Read article
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Two New, Useful and Facile Stability-Indicating UV Spectrophotometric Methods for the Determination of Rosiglitazone in Pharmaceuticals
Abstract: Rosiglitazone (ROS) is an antidiabetic drug belonging to the thiozolidine class. Two simple, rapid, sensitive, accurate and reproducible UV-spectrophotometric methods were developed and subsequently validated for the determination of ROS in bulk and tablet form. The methods are based on the measurement of the absorbance of the drug solution either in 0.1 M NaOH (NaOH method) or in 0.1 M HCl (HCl method) at 316 nm in both instances. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 8–19 Read article
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Modern Trends in Tungsten(VI) Analysis: From Smart Organic Reagents to High-Sensitivity Spectrophotometry
Abstract: The present review focuses on the spectrophotometric determination of tungsten(VI) using a wide range of organic reagents and their derivatives. Organic ligands have gained considerable importance in analytical chemistry due to their strong ability to form stable and highly colored complexes with tungsten(VI), which enhances the sensitivity and selectivity of spectrophotometric analysis. Various chromogenic reagents reported in the literature for tungsten(VI) determination have been critically examined and compared on the …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 2, 2026 · pp. 19–29 Read article
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Simultaneous Estimation of Irbesartan and Hydrochlorothiazide in Bulk and Tablet Dosage Form by UV-Spectrophotometry
Abstract: The present study describes a simple, accurate, precise and cost-effective UV Spectrophotometric method for the simultaneous estimation of irbesartan and hydrochlorothiazide in bulk and tablet dosage form. The solvent used was methanol and the absorption maxima for irbesartan and hydrochlorothiazide were found to be 250 nm and 270 nm respectively. A linear response was observed in the range of 4–20 µg/mL with a correlation coefficient of 0.998 for irbesartan and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 3, 2012 · pp. 9–17 Read article
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Development and Validation of Simple UV-Spectrophotometric Method of Quantization of Domperidone in Solid Dosage Formulation using Mixed Solvency Concept
Abstract: Organic solvents are most frequently employed in spectrophotometric analyses. They may be the sources of pollution. Some of them may be toxic, while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the present investigation, it was proposed to solubilize Domperidone by the use of mixed solvency concept. Domperidone shows maximum absorbance in the concentrations range of 10–50µg/ml at 287 nm. Method of analyses …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 2, 2017 · pp. 19–23 Read article
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Spectrophotometric Method for the Estimation of Aciclovir in Bulk Drug
Abstract: Aciclovir gives antiviral activity; one, new, simple, accurate, rapid, economical and precise procedure for spectrophotometric estimation of aciclovir in bulk drug. Aciclovir was estimated at 254 nm in 0.1 M sodium hydroxide, at 254 nm in 0.1 M hydrochloric acid, and at 254 nm in 7.4 phosphate buffers. The linearity range was found to be 5–30 µg/ml. The molar absorptivity was found to be 9.376x10 in 0.1 M sodium hydroxide, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 3, 2015 · pp. 1–3 Read article
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Simple, Direct and Stability-Indicating UV Spectrophotometric Assay of Pioglitazone Hydrochloride in Pharmaceuticals
Abstract: Pioglitazone hydrochloride (PGH) is an antihyperglycemic agent used in the treatment of type-2 diabetes mellitus. A simple and straight forward UV-spectrophotometric method is presented for the determination of PGH in bulk drug and tablets by measuring the absorbance of drug solution in 0.1M H2SO4 at 269 nm. A plot of absorbance versus concentration obeyed Beer’s law over 2–36 µg ml-1 concentration range (r = 0.9981) with a molar absorptivity of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 7–16 Read article
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Development and Validation of a UV-Spectrophotometric method for the Estimation of Nintedanib Esylate in Bulk and its Formulation
Abstract: The present work represents a UV spectrophotometric method for the estimation of Nintedanib Esylate in pure and its formulation. Methanol was used as a solvent. Nintedanib Esylate exhibit absorption maxima at 391 nm. The developed method obeyed Beer-Lambert’s law in the concentration range of 3-18 µg/ml having a line equation Y = 0.065x + 0.001 with a correlation coefficient of 0.999. There is no interference from any pharmaceutical excipients. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 49–53 Read article
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Development and Validation of Spectrophotometric and Colorimetric Method for the Determination of Ritonavir in its Bulk and Pharmaceutical Dosage Form
Abstract: A straightforward, exact, precise and sensitive UV spectrophotometric assay technique and a basic and sensitive colorimetric assay method have been created and validated for the quantitative estimation of Ritonavir from bulk drug and tablet formulations. UV spectrophotometric strategy which includes the assurance of Ritonavir in bulk medication and pharmaceutical dosage forms and has an assimilation greatest at 240 nm in methanol. The Beer's law was obeyed over the concentration range …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 32–41 Read article
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UV Spectrophotometric Method for the Estimation of Etoposide and its Application in Study of Polymeric Nanoparticles
Abstract: A rapid, economical, accurate and simple UV spectrophotometric method was developed for quantification of etoposide in bulk and pharmaceutical formulation and its application in the study of polymeric nanoparticles. The samples were quantified at 284 nm in both methanol and phosphate buffer saline (PBS) at pH 7.4. The method was linear (r2 > 0.99) over the range of 20–100 μg/ml, precise (RSD < 5%), accurate (recovery values close to 100%), …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 46–51 Read article
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A New Extractive Spectrophotometric Method for the Determination of Oxydemeton methyl in Relation to its Environmental and Toxicological Analysis
Abstract: In view of the wide agricultural use of oxydemeton methyl insecticide and its associated toxic effects, it has been determined in the soil, water and foodstuffs to assess its environmental relevance. A new, simple and sensitive extractive spectrophotometric method has been developed for the purpose. It is based on microwave-assisted alkaline hydrolysis of insecticide to form 2-ethylsulfinyl-ethyl mercaptan and transformation of the latter through reaction with carbon disulphide and nickel(II) …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 2, 2012 · pp. 1–11 Read article
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Spectrophotometric Method for the Estimation of Levosulpiride in Bulk Drug and Formulations
Abstract: Levosulpiride having D2-dopamine receptor antagonistic activity gives ant depressive and antiulcer effect. There are three new simple accurate, rapid, economical and precise procedures for spectrophotometric estimation of Levosulpiride in bulk and pharmaceutical formulation. Levosulpiride was estimated at 291.5 nm in 0.1 N NaOH, 290 nm in 0.1 N HCl and 292.5 nm in 6.8 phosphate buffer. Linearity range was found to be 10–50 µg/mL in all the three methods. The …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 1, 2015 · pp. 19–23 Read article
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Simultaneous Estimation of Atenolol and Nifedipine to be incorporated in Buccal Patch: Method Development and Validation by UV-Spectrophotometric Approach
Abstract: A simple, precise, accurate and reproducible spectrophotometric method has been developed for the simultaneous estimation of Atenolol and Nifedipine. Atenolol and Nifedipine are used in combined dosage form for cardiovascular diseases. Hence, it is necessary to develop a method to analyze the two drugs simultaneously by UV-spectroscopic method. Simulated salivary fluid of pH 6.8 was used as the medium. Simultaneous equation method was developed as per ICH guidelines. The absorption …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 2, Issue 1, 2015 · pp. 28–32 Read article
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Soil Adsorption Study of Thiram on Four Indian Soils by Extractive Spectrophotometry
Abstract: Concern about the environmental impact of an extensive use of pesticides has prompted research into the environmental fate of these agents which is strongly influenced by the interactions between the pesticides and soil. With a view to studying the fate of thiram fungicide in soil and the extent of surface and groundwater contamination, the soil-adsorption of thiram on four Indian soils of different soil characteristics has been studied by an …
Published in Research and Reviews: A Journal of Toxicology · Vol. 1, Issue 1-3, 2011 · pp. 56–62 Read article
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Development and Validation of 1, 1-Cyclohexanediacetic Acid Monoamide by using Spectrophotometry
Abstract: An accurate and sensitive spectrophotometric method is developed for the determination of 1, 1-Cyclohexanediacetic acid monoamide. The method is based on the reaction of carboxylic acid group of 1, 1-Cyclohexanediacetic acid monoamide with the mixture of potassium iodate and potassium iodide to form yellow colored product in double distilled water which measured at 346 nm against the reagent blank prepared simultaneously. Beer’s law obeyed in the concentration range of 14.14–42.42 …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 5, Issue 2, 2014 · pp. 11–17 Read article
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Simultaneous Estimation of Baclofen and Nimesulide: Method Development and Validation by UV-Spectrophotometric Method
Abstract: A simple, accurate, precise, reproducible and economical UV spectroscopic methods for simultaneous estimation of Baclofen and Nimesulide in tablet dosage form have been developed. The method is based on the principle of Q-Analysis where in the absorbance was measured at 227 nm (iso-absorptive point) and 218 nm (λmax of Baclofen) in simulated gastric fluid (pH 1.2). Baclofen and Nimesulide show linearity at all the selected wave- lengths and obeys Beer’s …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 6–11 Read article
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Analysis of benzoic acid in fruit juice and some soft drinks in Benghazi market by UV- spectrophotometric method
Abstract: The utilization of preservative substances is extensive in various industries, with particular prominence in the food industry. In this study, we investigated the estimate of benzoic acid as a preservative substance, which is widely used to preserve juices and carbonated beverages. Fifteen samples were collected from some markets in Benghazi . The spectrophotometer was utilized to take measurements at a wavelength of 228nm The pH value was measured using a …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 75–80 Read article
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Rapid Determination of Content of Etoricoxib in Pharmaceutical Formulations by Mid-Infrared Spectroscopy
Abstract: The present paper is an attempt to highlight a new technique FTIR-ATR along with its referenced validated method, UV spectrophotometric analysis. Different concentrations of etoricoxib were used as samples to draw standard plot. From different samples, a transmission spectrum was recorded according to the prominence of peaks. The present study has chosen the three most prominent peaks for analytical purpose in case of samples of etoricoxib and marketed formulations. All …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 4, Issue 3, 2013 · pp. 20–32 Read article
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Development and Fabrication of Biohydrogel for Targeted Delivery of Delafloxacin for Bacterial Skin Infections
Abstract: The escalating challenge of bacterial resistance necessitates innovative drug delivery systems to enhance the efficacy of antibiotics. This study focuses on the development and optimization of a biohydrogel formulation for the targeted delivery of Delafloxacin, aiming to improve its therapeutic outcomes against resistant bacterial strains. Utilizing a 3² factorial design, biohydrogel formulations incorporating Poly(N-isopropylacrylamide) (PNIPAM) and Genipin were synthesized. The optimization process was guided by Design Expert software, focusing on …
Published in Research & Reviews: A Journal of Drug Design & Discovery Read article
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Microwave Assisted Digestion For Cadmium Analysis in Yoghurt Samples Using Atomic Absorption Spectrophotometer
Abstract: This paper presents an innovative approach for the digestion of dairy products aimed at determining heavy metal concentrations using atomic absorption spectrophotometry. The present study was conducted to assess the concentration of cadmium in different Yoghurt samples. A total of 80 random samples of dairy products (20 each of sour Yoghurt, sweet Yoghurt, flavoured Yoghurt, and homemade Yoghurt) were collected from different areas of Kota city. For the analysis of …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 2, 2024 · pp. 24–39 Read article