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7 articles for “signal transduction”
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Nutrition Induced Remodeling Dynamics of Cell Membranes: Implications for Performance, Health, and Welfare Issues in Food Animals
Abstract: Cell membranes represent dynamic structural and functional platforms that integrate nutritional signals with cellular metabolism, immune competence, and physiological adaptation in food animals. Beyond their classical role as selective barriers, membranes actively regulate nutrient transport, signal transduction, and bioenergetics through highly responsive lipid and protein networks. Dietary components, particularly fatty acids, vitamins, minerals, amino acids, and bioactive compounds, critically influence membrane composition, fluidity, and stability, thereby shaping cellular function and …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 25–37 Read article
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Polymer-Based Acousto-Optic Ultrasonic Sensor for Non-Destructive Evaluation of Dielectric Insulation
Abstract: A dual-polymer fiber-optic sensor for monitoring partial discharge (PD) activity in high-voltage polymeric insulation is presented in this work for non-destructive evaluation and dielectric testing applications. Dielectric weakness within polymeric insulation leads to partial discharge activity, generating ultrasonic acoustic waves that propagate through the medium. The developed sensing assembly comprises a conical polymer-based horn that gathers and concentrates the ultrasonic acoustic emission energy generated by dielectric weakness, and a single-mode …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 11–24 Read article
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Thin Film Technology in Sensor Manufacturing – A Technical Discussion
Abstract: Thin‑film technology has become the cornerstone of modern sensor manufacturing, enabling the convergence of miniaturisation, multifunctionality, and cost‑effective mass production. This paper surveys the latest advances in deposition techniques—ranging from magnetron sputtering and chemical vapour deposition to atomic‑layer deposition (ALD) and ink‑jet‑printed sol‑gel processes—and examines how their unique material‑control capabilities translate into performance gains across the sensor spectrum (chemical, physical, and bio‑sensing). By integrating nanoscale thickness control (≤ 10 nm) …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 13, Issue 1, 2026 · pp. 48–58 Read article
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An Overview on Energy Harvesting Using Piezoelectric Material for Wi-Fi Systems
Abstract: The rapid proliferation of wireless-networked devices has intensified the demand for sustainable, maintenance-free power sources that can keep small-scale Wi-Fi modules operational in hard-to-reach or infrastructure-limited environments. This study investigates the feasibility of harvesting ambient mechanical energy using piezoelectric transduction technology and directly feeding the harvested power to a low-power Wi-Fi communication subsystem. A compact energy-harvesting module was engineered from lead-zirconate-titanate (PZT) cantilevers with resonant frequencies tuned to the dominant …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 4, Issue 1, 2026 · pp. 56–63 Read article