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9 articles for “outbreak preparedness”
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Ebola Vaccination: From Outbreak Control to Global Preparedness
Abstract: Ebola virus disease (EVD) is one of the most dreadful and lethal viral infections, continuously generating threatening impacts on the health of the global population, especially in low-resource environments. This review provides an overview of Ebola vaccines, focusing on virology, vaccine development, clinical trials, regulatory approval, deployment plans, and ethical issues. Recombinant viral vector platforms have seen the development of successful vaccines, with the most prominent example being rVSV-ZEBOV, which …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 27–37 Read article
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Monkeypox Virus (MPXV): Epidemiology, Pathogenesis, and Control Strategies: Exploring the Recent Resurgence of Monkeypox, Its Transmission Dynamics, Clinical Manifestations, and Public Health Responses
Abstract: Monkeypox virus (MPXV) has re-emerged as a significant public health concern, with increasing cases reported worldwide. This zoonotic virus, primarily endemic to Central and West Africa, has demonstrated the potential for human-to-human transmission, leading to outbreaks in non-endemic regions. Unlike smallpox, which was eradicated through mass vaccination, monkeypox continues to persist due to the lack of widespread immunity and effective antiviral treatments. The resurgence of MPXV in recent years, particularly …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 29–34 Read article
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A Hybrid Mathematical Model for Epidemic Outbreak Forecasting Using Machine Learning and Cloud Computing
Abstract: The increasing frequency of infectious disease outbreaks has emphasized the necessity for intelligent epidemic surveillance systems capable of predicting disease spread at an early stage. Conventional outbreak detection approaches rely heavily on delayed statistical reporting and manual monitoring techniques, resulting in reduced responsiveness during critical periods. This paper presents a mathematical predictive framework for epidemic outbreak detection using machine learning and cloud computing technologies. The proposed framework integrates the Susceptible–Infected–Recovered …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 13, Issue 2, 2026 · pp. 01–06 Read article
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A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article
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Disease X: Unveiling the Unknown Pathogen and Enhancing Global Preparedness
Abstract: “The concept of “Disease X” was introduced to drive the creation and refinement of versatile technologies such as vaccines, therapeutic drugs, and diagnostic tests, which could be swiftly adapted and utilized in response to future infectious disease outbreaks with epidemic or pandemic potential. The aim was to establish a proactive approach to emerging health threats by developing platform technologies capable of addressing a broad spectrum of potential pathogens. The COVID-19 …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 3, 2024 · pp. 15–20 Read article
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Evaluation of Emergency Response Plans in Industrial Environments Using Simulation Techniques
Abstract: Industrial facilities, particularly those in the chemical, manufacturing, and energy sectors, face significant hazards due to their complex operations and the handling of hazardous materials. Ensuring the safety of workers and minimizing the impact of incidents require robust and effective emergency response plans (ERPs). Traditional evaluation methods, such as drills and tabletop exercises, often fall short in replicating the complexities of real-world emergencies. These methods may lack the realism needed …
Published in Journal of Industrial Safety Engineering · Vol. 11, Issue 3, 2024 · pp. 6–10 Read article
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From Outbreak to Output: Uganda’s COVID-19 Research Trajectory Through a Scientometric Lens
Abstract: The COVID-19 pandemic sparked an extraordinary global expansion in scientific research, with notable and growing contributions from low- and middle-income countries, including Uganda. This study presents a comprehensive scientometric analysis of COVID-19 related research output from Uganda, aiming to examine publication trends, authorship patterns, collaboration networks, source impact, and thematic focus. Bibliographic data were retrieved from the PubMed database using an advanced search strategy: “(COVID-19) OR (SARS-CoV-2)) AND (Uganda)” for …
Published in Journal of Advancements in Library Sciences · Vol. 13, Issue 1, 2026 · pp. 48–60 Read article
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Unlocking Novel Drug Targets and Therapeutic Advancements Against RNA Viruses: Insights from HMPV and SARS-CoV-2
Abstract: Re-emerging RNA viruses pose a significant epidemiological welfare threat due to their high mutation rates, potential for zoonotic transmission, and capacity to cause widespread outbreaks such as Human Metapneumovirus (HMPV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Influenza, etc. The rapid evolution and re-emergence of these viruses necessitate the development of novel drug targets and therapeutic strategies to combat existing and future outbreaks. This study focuses on structural as well …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 54–86 Read article
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Contextualising health-disaster risk reduction pillars for under-resourced rural secondary schools in Limpopo Province, South Africa
Abstract: School communities in under-resourced rural settings face a disproportionate burden of health-related disasters, including outbreaks, water and sanitation failures, food insecurity and compound events that disrupt learning and wellbeing. Yet school based disaster risk reduction (DRR) evidence in Southern Africa is uneven with limited empirically guidance tailored to the organisational and infrastructural realities of disadvantaged schools. Drawing on the Comprehensive School Safety Framework and the World Health Organization's Health Emergency …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 124–135 Read article