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8 articles for “loci”
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Population Genetics and Diversity of Human Adenovirus in Two Tertiary Hospitals in Southern Nigeria
Abstract: The study of dynamic changes in genetic heterogeneity can shed light on the evolution of viruses because it is known that the genetic variety of viral populations within their hosts affects disease progression, treatment outcome, medication resistance, cell tropism, and transmission risk. Our study's primary goal is to identify trends in the genetic makeup and variety of human adenoviruses using samples taken from children who attend two distinct tertiary hospitals …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 3, 2022 · pp. 37–44 Read article
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ADVANCEMENTS AND CHALLENGES OF MODERN BREEDING OVER CONVENTIONAL BREEDING
Abstract: Plant breeding dates back thousands of years, when people first deliberately bred plants based on visually pleasing characteristics. The domestication of wild plants aided this process, resulting in the evolution of numerous breeding strategies over time. Conventional breeding, which is distinguished by selective breeding based on superior performance, used procedures such as pure-line selections, mass selection, backcross breeding, recurrent selection, and hybridization. While effective, classical breeding procedures were time-consuming and …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–5 Read article
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Leveraging Genome-Wide Association Studies for Precision Medicine in Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally, with complex etiologies involving genetic, environmental, and lifestyle factors. Genome-wide association studies (GWAS) have significantly advanced the understanding of genetic underpinnings of CVDs by identifying numerous risk loci and variants associated with various cardiovascular conditions. This review explores the potential of GWAS to drive precision medicine in cardiovascular diseases by linking genetic data with clinical outcomes, providing insights into disease …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 35–39 Read article
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Heterosis in Plants
Abstract: It refers to hybrid vigor or heterosis; herein, the offspring expressed better traits than one or both parent lines. This most often manifests in crop breeding as increased yield in F1 hybrids compared with their parents. Developing high-yielding hybrid cultivars across a wider range of crops represents an important strategy for addressing future food security. However, conventional hybrid breeding approaches are fraught with significant challenges in many self-pollinating crops, such …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 2, 2025 · pp. 21–31 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Harnessing Bacteria for Next-Generation Data Storage Technologies – A Review
Abstract: The exponential increase in global digital information has created a pressing need for storage technologies that are more durable, compact, and sustainable than conventional electronic media. While hard drives, solid-state drives, and cloud-based systems have transformed information management, they face severe limitations related to storage density, energy consumption, maintenance costs, and long-term preservation. Researchers have, therefore, begun exploring biological systems as alternative information storage platforms. Among these, bacteria have emerged …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Clinical Practice: The Differential Diagnosis of Dental Pain
Abstract: In clinical dental practice, patients often present with pain in the oral cavity. While some oral pain may be generalized in nature, the clinician has to consider other factors that involve pain and discomfort. Many symptomatic teeth do not need endodontic treatment – on the contrary, they have undiagnosed occlusal problems, caries, fractures or referred pain. For the teeth needing endodontic treatment, this paper provides several modes of diagnostic methodology. …
Published in Research and Reviews: A Journal of Dentistry · Vol. 5, Issue 2, 2014 · pp. 18–23 Read article
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Pathways of Periodontal Disease and Alveolar Bone Loss in Type II Diabetes
Abstract: or poorly-controlled type II diabetes often exhibits a high morbidity of periodontal pathology. Food impaction in defective restorations or open proximal contacts often leads to infection, carious lesions, periodontitis, alveolar bone loss and often tooth loss. An iatrogenic injury occurs when restorations are defective, fractures, or have open proximal contacts and are not planned to be repaired or replaced. In addition to having poor therapeutic outcomes, defective restorations or open …
Published in Research and Reviews: A Journal of Dentistry · Vol. 4, Issue 3, 2013 · pp. 28–35 Read article