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3 articles for “hypothetical protein”
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Homology Modeling and in silico Characterization of a Hypothetical Protein of Arabidopsis lyrata ssp. Lyrata
Abstract: Arabidopsis lyrata, a plant belonging to brassicaceae, is a model organism for studying evolutionary and ecological genetics. Most of the proteins of this plant have remained uncharacterized and their functional roles are still to be elucidated. In this investigation, we have attempted to characterize one such hypothetical protein in terms of its physico-chemical properties, secondary and tertiary structure features by in silico study. The protein was classified under glycoside hydrolase …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 3, Issue 2, 2013 · pp. 1–5 Read article
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Studies of CRISPR/CAS 9 Gene Interactions in Streptococcus pyogenes
Abstract: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/cas9/single guide RNA (sgRNA) system is a DNA editing system in mostly studied in prokaryotes. Studies of CRISPR/cas9 gene interactions in Streptococcus pyogenes has been conducted using in silico approaches in the present research. Proteins like DNA polymerase I (polA), NAD-dependent DNA ligase LigA (ligA), Translaldolase (tal), Thymidine kinase (tdk), Streptococcal exotoxin I (speI), Phage associated protein (SPy_0679) and Hypothetical proteins like SPy_1047, SPy_1048, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 32–38 Read article
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Structure based pharmacophore Modelling of compounds against Neurodegenerative disorder – Amyotrophic Lateral sclerosis
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle dysfunction, paralysis, and eventually death. These diseases are classified as ALS variations because autopsies reveal abnormalities in both upper and lower motor neurons. These disorders account for only 10% of all adult-onset motor neuron disease cases. Despite extensive research efforts, effective therapeutic interventions for ALS remain limited. Structure-based pharmacophore modeling …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 1–17 Read article