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2 articles for “desferal”
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Desferrioxamine-induced Ototoxicity (SNHL) in β-Thalassaemia
Abstract: Thalassaemia is a hereditary disorder requiring regular blood transfusion. The repeated transfusion results in an iron overload state with succeeding complications. Iron chelation therapy with desferrioxamine removes excess iron and its prolonged usage causes ototoxicity. This is a rare disease observed in the ENT (OP) Department, Rajiv Gandhi Institute of Medical Sciences (RIMS) [a 750 bedded tertiary teaching hospital], Kadapa, AP, India. A 12-year-old female patient was presented with complains …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 1, 2016 · pp. 10–12 Read article
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Enhanced Iron Removal in Experimental Iron Overload by Nanoniosomes of Desferrioxamine
Abstract: This preliminary study explores the feasibility of employing nanocapsules prepared from nonionic surfactant vesicles (niosomes) as a carrier for an iron-chelating agent, Desferrioxamine (DFO, Desferal), to enhance iron excretion from the body. The methodology consisted of creating an iron overload model in an experimental animal followed by measurement of iron excretion pattern in the urine by atomic absorption spectrophotometry. Niosomes were prepared with span 60: cholesterol:dicetyl phosphate by the lipid …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 5, Issue 1, 2014 · pp. 14–20 Read article