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8 articles for “and antitubercular.”
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Design, Synthesis and Evaluation of Antitubercular Activity of Mannich Bases of Isoniazid-Containing Thiazolidin-4-one Rings
Abstract: Isoniazid (INH), the established antitubercular drug was selected as the lead for the design and development of antitubercular agents by many researchers. 4-thiazolidinones are well known heterocyclic compounds for their spectrum of biological activities such as antibacterial, antifungal [1], anticancer [2], antitubercular, anthelmintic, anti-inflammatory [3], analgesic [4], antithyroid, local anaesthetic, monoamine oxidase inhibition, anti-Toxoplasma gondii activity etc [5]. Modification of thiazolidinones via Mannich reaction to improve biological activity is also …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 1–12 Read article
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Bedaquiline: An In-Depth Exploration into Its Antitubercular Significance
Abstract: Tuberculosis is still a leading infectious disease and a major threat to public health. Although there has been a slow decrease in the incidence over years, its “hard to kill nature” is responsible of about 2 million deaths in HIV infected individuals annually. Bedaquiline, a Diaryl-Quinoline drug was fast-track approved as an orphan drug to combat drug resistance. It shows potent activity against Mycobacterium tuberculosis by interfering with the production …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 06–14 Read article
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Review of Mercaptoimidazoles as Anti-infective Agents
Abstract: 2-Mercaptoimidazole or imidazol-2-thione is five-membered heterocyclic ring having two nitrogen, same as imidazole and sulphur group attached to it at 2nd position. Imidazol-2-thione and its derivatives shows the biological activities such as antibacterial, fungicidal, antioxidant, antitumor, and antitubercular. In this review we have collected information about the 2-Mercaptoimidazole nucleus and its antimicrobial activity for further research and development.
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 1, 2022 · pp. 41–48 Read article
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Use of NMR and Other Spectroscopy Techniques in Heterocyclic Oxadiazole Derivatives Studies: A Review
Abstract: It was possible to create a number of novel symmetrical 2,5-dialkyl-1,3,4-oxadiazoles with substituents including carboxymethylamino, isopropyloxycarbonylmethylamino, and bromine at the terminal positions of the alkyl groups. The multistep process that was devised used hydrazine hydrate, phosphorus oxychloride, and commercially available acid chlorides that varied in alkyl chain length and terminal substituent.Diisopropyliminodiacetate was an easy way to substitute the intermediate bromine-containing 2,5-dialkyl-1,3,4-oxadiazoles. This was followed by hydrolysis in an aqueous methanol …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 07–13 Read article
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Prevalence of Adverse Drug Reactions and Risk Factors Associated with first Line Anti- Tuberculosis Drugs
Abstract: Background: The recommended first line treatment of active tuberculosis (TB) consists of rifampicin (R), isoniazid (H), ethambutol (E) and pyrazinamide (Z). The regimen is highly effective in treating active TB however it is associated with various adverse drug reactions (ADRs) posing undeniable challenges to therapy success. Objectives: To determine the prevalence of ADRs and risk factors associated with first-line anti-tuberculosis medications. Methods: A quantitative cross-sectional descriptive study conducted at the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 2, 2022 · pp. 9–16 Read article
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A Review on Vetiveria zizanioides Species
Abstract: Vetiver is a perennial grass that can grow under intense climatic conditions such as drought, heavy rains and high temperatures. It is found mostly in Asian countries, belongs to graminaceae or poaceae family. It is commonly known as Khus Khus. Vetiver is a tall, tufted, aromatic grass with a straight stalk, long narrow leaves and an extensive root system. Aromatic oil is derived from vetiver roots, which can be used …
Published in Research & Reviews : Journal of Herbal Science · Vol. 9, Issue 3, 2020 · pp. 1–3 Read article
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1,2,3,4-Tetrahydroquinoline: A Versatile Nucleus in the New Millennium
Abstract: Tetrahydroquinoline nucleus containing molecules are well known for their presence in natural products mainly in alkaloids, which constitute the active class of compounds possessing wide spectrum of biological activities. Tetrahydroquinoline skeleton is often used for the design of several synthetic compounds with diverse pharmacological properties. An immense wide range of pharmacological utility of such nucleus has inspired many synthetic and medicinal chemists to develop novel strategies for their synthesis, which …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 1, 2016 · pp. 1–18 Read article
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DESIGNING OF COUMARIN ANALOGS: A NEW INSIGHT AS ENOL ACYL CARRIER PROTEIN REDUCATSE INHIBITORS
Abstract: Tuberculosis was almost certainly the leading cause of death in Europe and the United States in recorded history, although because of the multifarious forms of the disease. Based on literature we have designed coumarin linked with thiadiazole derivatives as antitubercular agents. To determine structural requirements, we carried out molecular docking study in which we found that our designed molecule have similar binding with enoyl acyl carrier protein reductase (InhA). The …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 1–5 Read article