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14 articles for “adjuvants”
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Prospective Evaluation of the Optimal Concentration and Effect of Epinephrine as an Adjuvant to Local Anesthetics for Prolonging Block Duration and Reducing Systemic Toxicity in Outpatient Surgery
Abstract: Purpose: To evaluate the optimal concentration and effect of epinephrine as an adjuvant to local anesthetics for prolonging block duration and reducing systemic toxicity in outpatient surgery. Methods: The study involved a randomized double-blind clinical trial on 80 adult patients awaiting day-care extremity surgery. The patients were randomly assigned to two groups of equal size. One group, Group E, was given the local anesthetic agent along with epinephrine as an …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 64–69 Read article
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Review on Effect of the Chemical Composition of some Pharmaceutical Vaccines and their Biochemical Efficacy with Chemical Techniques
Abstract: Chemical compounds are fundamental components in the formulation of medicines and vaccines, playing a critical role in ensuring their safety, stability, and effectiveness. Vaccines contain a combination of active and inactive ingredients, including weakened or inactivated viruses or bacteria, toxins, preservatives, stabilizers, adjuvants, antibiotics, and minerals. The active ingredient is an antigen, which stimulates the body's immune system to recognize and defend against specific infectious diseases. Adjuvants, such as aluminum …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 2, 2026 · pp. 01–09 Read article
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Examining the Impact of a Nurse Navigator Program on Anxiety, Psychological Well-being, and Quality of Life in Breast Cancer Patients at a Tertiary Care Hospital in Haryana: A Randomized Controlled Trial
Abstract: Background of study: Breast cancer stands as the leading cancer type affecting women and remains a significant contributor to female mortality. It is a complex ailment influenced by multiple factors. Globally, in 2020, approximately 2.3 million women received diagnoses of breast cancer, resulting in 685,000 fatalities. This condition can profoundly impact various aspects of a person's existence, encompassing physical, psychological, emotional, social, and familial spheres. A notable observation is the …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 31–39 Read article
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Innovative Approaches in Excipient Co-Processing: A Comprehensive Review
Abstract: Co-processing of existing excipients is an innovative strategy in pharmaceutical formulation that offers a cost-effective, efficient alternative to the development of entirely new excipients. This process involves combining two or more well-established excipients to create new material with enhanced properties, thereby improving the functionality, performance, and manufacturability of pharmaceutical products. By leveraging the unique characteristics of each excipient, co-processing can significantly enhance attributes, such as flowability, compressibility, solubility, stability, and …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 34–51 Read article
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Nano-Materials in Vaccine Formation and Chemical Formulae’s for Vaccination
Abstract: For centuries, vaccines have been a cornerstone of public health, preventing debilitating and deadly diseases. However, the development and delivery of effective vaccines have always been met with challenges. From stability issues and limited immune response to the need for specific targeting, scientists are constantly seeking innovative approaches to improve vaccine efficacy and accessibility. Enter nanomaterials – minuscule materials with dimensions at the nanoscale – offering a powerful toolkit to …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 3, 2025 · pp. 27–39 Read article
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Nano-Chemical Revolution in Vaccinology: A Study
Abstract: The development of traditional vaccines, reliant on attenuated pathogens or purified proteins, has historically been limited by slow development timelines, poor stability, and low immunogenicity requiring potent, often non-specific, adjuvants. This synthesis argues that the convergence of nano-material science and meticulous chemical engineering represents the next major paradigm shift in preventative medicine. Nano-materials, particularly Lipid Nanoparticles (LNPs) and various polymeric or inorganic scaffolds, have transitioned from theoretical constructs to essential …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 Read article
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Exploring Nutool (Irrigation) as A Treatment Method in Ilaj Bit Tad-Beer (Regimenal Therapy)
Abstract: The Unani system of medicine employs four primary modes of treatment: Illaj bil ghiza (dietotherapy), Illaj bil Dawa (pharmacotherapy), Illaj bit tadbeer (Regimenal therapy), and Illaj bil yad (surgery). Illaj bit Tadbeer encompasses a range of regimenal interventions, including Hijamah (cupping), Irsal alaq (leeching), Fasd (venesection), Dalak (massage), Nutool (irrigation), Qay (Emesis), Idrar-i-Bawl (Diuresis), Tariq (Diaphoresis), Munzij and Mu'shil therapy (Concoction and purgation), Bukhoor (medicated steam), kayy (cauterization), Huqna (enema), …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 1–6 Read article
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Uterine Leiomyosarcoma: A Diagnostic Dilemma
Abstract: Tumours that fall under the category of uterine malignancies include carcinosarcomas, leiomyosarcomas, endometrial stromal sarcomas, and undifferentiated sarcomas. Of them, leiomyosarcoma is the most common subtype, while still quite uncommon—it accounts for 1% to 2% of uterine cancers. Since postmenopausal bleeding is typically present in leiomyosarcomas, prompt detection is essential for successful treatment. This case study features a 50-year-old female patient who had postmenopausal bleeding, which is a common sign …
Published in International Journal of Pathogens · Vol. 1, Issue 1, 2024 · pp. 38–42 Read article
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Role of Nasya in Pakshaghata: An Evidence-Based Review Study on Its Anatomical Pathway and Therapeutic Action
Abstract: Introduction: Intranasal administration (Nasya), a time-honoured Ayurvedic procedure, offers a unique advantage in treating pathology of neurological and systemic diseases due to its targeted and non-invasive nature. Pakshaghata, a neurological disorder characterized by hemiplegia in ancient Ayurvedic literature, where it is classified as a Vatavyadhi. Methods: By going through all the available literatures and information, this review study explores the concept of Nasya in the context of Pakshaghata management, investigating …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 2, 2025 · pp. 1–8 Read article
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Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review
Abstract: Fungal-derived nutraceuticals represent a rapidly expanding field in biomedical research, offering a rich source of bioactive compounds with diverse therapeutic applications. This comprehensive review examines the physiotherapeutic and health-promoting properties of fungal metabolites, including polysaccharides, terpenes, proteins, peptides, alkaloids, fatty acids, vitamins, and minerals. Fungi produce over 9,000 bioactive compounds from approximately 22,500 microbial metabolites, with less than 5% of the fungal kingdom explored [1] . The major bioactive constituents …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Pharmacological Comparison of Turmeric and Non-Steroidal Anti-Inflammatory Drugs in Pain Relief
Abstract: Pain is one of the most frequently encountered clinical symptoms affecting millions globally and is typically treated pharmacologically with nonsteroidal anti-inflammatory drugs (NSAIDs). However, long-term use of NSAIDs is associated with adverse effects such as gastrointestinal, renal, and cardiovascular issues. In recent years, turmeric and its main active compound, curcumin, have received considerable attention for their reported anti-inflammatory, analgesic, and antioxidant properties as natural therapeutic options. This review seeks to …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 19–28 Read article
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India’s Pioneering Advancements in Vaccinology: Challenges and Milestones – Part 2
Abstract: India has become a global leader in vaccinology, playing a vital role in developing, producing, and distributing vaccines that protect millions of lives. By embracing advances in molecular immunology, recombinant antigen technology, and virus-like particle (VLP) platforms, the country has created affordable vaccines against major diseases, including poliovirus, rotavirus, and SARS-CoV-2. National initiatives, like Mission Indradhanush and Vaccine Maitri, have helped expand immunization coverage, improve public health, and share vaccines …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 2, 2026 Read article
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Role of the Surgical-Ward Nurse in Identifying, Escalating, and Managing Postoperative Anastomotic Leak in Colorectal Patients: A Narrative Synthesis in an Australian Nursing Perspective
Abstract: Purpose: Postoperative colorectal anastomotic leak (AL) is one of the most feared complications after colorectal surgery because of its association with sepsis, reoperation, mortality, prolonged hospital stay, delayed adjuvant therapy, and permanent stoma formation. This narrative practice review outlines the frontline role of surgical-ward nurses in the early identification, escalation, and interim management of AL within the Australian acute-care context. Methods: A narrative synthesis of contemporary consensus statements, systematic reviews, …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 1, 2026 · pp. 7–12 Read article