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19 articles for “Tet-on”
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InSilico Analysis and Homology Modeling of Tetrahydroprotoberberine Oxide involved in the Berberine Biosynthesis
Abstract: Objective: Berberine, a bioactive compound found in various plant species, exhibits diverse pharmacological properties with potential applications in pharmaceutical research. The biosynthesis of berberine involves several enzymatic steps, with (S)-tetrahydroprotoberberine oxidase playing a pivotal role. This study aimed to elucidate the structural and functional characteristics of (S)-tetrahydroprotoberberine oxidase to better understand its role in berberine biosynthesis and its potential biotechnological applications. Methods: Using bioinformatics tools and computational methods, the physicochemical …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 7–26 Read article
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Horizon Scanning and Early Assessment of Health Technologies for the Treatment of Orphan Diseases
Abstract: The theoretical foundations and regulatory framework of the processes of the formation of an effective health technology assessment (HTA) system at the early stages of the life cycle of medicines are analyzed in the article. Particular attention is paid to horizon scanning (HS) and early assessment of expensive innovative drugs utilized for treating rare diseases. In order to inform policymakers, purchasers, and providers (to prioritize MT research, financial, and operational …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 32–39 Read article
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Advanced Helmet Recognition System with Integrated Number Plate Detection for Enhanced Traffic Monitoring Using Deep Learning
Abstract: This study focuses on the crucial problem of non-adherence to traffic regulations, particularly with the compulsory use of helmets by motorcyclists. Motorcycle accidents have a greater mortality rate compared to other types of accidents, indicating a need for a more effective enforcement strategy. Current procedures depend on traditional techniques where traffic officers manually observe traffic rule infractions through patrols and monitoring CCTVs, requiring substantial labor and time resources. The inherent …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 2, Issue 1, 2024 · pp. 9–18 Read article
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The Current State of Huntington's Disease Treatment: An Overview of Palliative Care and Symptom Management
Abstract: Huntington's disease (HD) is a neurodegenerative ailment that adversely affects the basal ganglia and the cortex of the brain. Although there is no recognized cure for HD, symptomatic relief and therapeutic management of the condition have improved over the course of time. This review paper provides an up-to-date overview of the current treatment options and symptom management strategies utilized in the care of HD patients. Additionally, it highlights the existing …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 Read article
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Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
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Molecular Docking Studies of Nyctanthes arbor-tristis Phytochemicals for Targeting TNF Receptor in Arthritis
Abstract: Rheumatoid Arthritis is an autoimmune disorder which results in inflammation. Tumor necrosis factor-alpha (TNF-α) is responsible for the progression of inflammatory arthritis by promoting immune cell activation and cytokine release. The present study explores the potential of bioactive compounds derived from Nyctanthes arbor-tristis (Parijat) in modulating TNF receptor activity through molecular docking. Computational methods were employed to evaluate the binding affinity of selected phytocompounds from N. arbor-tristis against the extracellular …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 11–21 Read article
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In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
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Molecular Docking Studies of Wildtype P53 with Damnacanthal and Scopoletin- Phytochemicals Derived from Morinda Citrifolia
Abstract: Cancer is a prominent cause of mortality globally, and it has the potential to impact any region of the body. The tumor suppressor protein P53 plays a significant role in inhibiting tumor growth by regulating DNA repair, inducing cell cycle arrest, promoting senescence, and triggering apoptosis when confronted with genotoxic stress. P53 is found mutated in 50% of cancers where it loses its tumor suppressive properties and gains oncogenic properties …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 20–31 Read article
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Phytase enzyme and its remarkable effects on chicken health
Abstract: Phytase enzyme catalyzes the hydrolysis of Phytate to mono, di, tri, tetra and penta Phosphate of Myoinositol and Inorganic Phosphate. Cereals, legumes and oilseeds are the main ingredients of animal feed. Phytic acid or phytate is the chief storage form of phosphorus in the feed obtained from these plant sources. Phytate bound important mineral, metal ions and amino acids with it, and in this way it is anti-nutritional element. Simple …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 37–41 Read article
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Organometallic Osmium Compounds in Cancer Therapy
Abstract: The exploration of organometallic complexes with osmium as potential anticancer agents was indeed an area of ongoing research. These complexes were being investigated for their unique properties and mechanisms of action against cancer cells. However, it’s essential to note that the field of scientific research is dynamic, and new findings may have emerged since then. Organometallic complexes with osmium can be designed to exhibit specific features that make them promising …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 2, 2023 · pp. 01–25 Read article
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Chemical Profile and Toxicity of Fresh and Dry leaves of the Essential Oils of Vetiveria zizanioides (L.) Nash. From Southwest Nigeria
Abstract: The fresh and dry leaves of Vetiveria zizanioides (L.) Nash (Gramineae) plant was collected, air dried and authenticated at the University of Ibadan Herbarium with voucher number: UIH-23237. The plant's dried, fresh leaves were hydro distilled in a Clevenger device to extract the essential oils. The oils were characterized by Gas Chromatography-Mass Spectrometry (GC – MS) while the toxicity of the essential oils was tested using brine shrimps’ lethality assay. …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 44–49 Read article
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Development of Novel Materials with Photocatalytic Effect
Abstract: For capturing solar energy and for converting it into electric power, it is utmost essential to design materials that can be used for this purpose. Generally, the materials deployed for converting solar energy into electric energy are sensitive to UV-radiation. If the material used for this purpose are sensitive to visible light, it will be the breakthrough research. It has been a challenge to design materials with novelty of being …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 1, Issue 2, 2023 · pp. 25–39 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Synthesis, Characterization, and Reactivity of Bivalent Tin(II) with 4-Tert-butylphenol
Abstract: Bivalent tin(II)-4-tert. butylphenoxide of composition Sn(OC6H4X-4)2(I), where X = But, has been synthesized by the reaction of stannous chloride (SnCl2) with bimolar amounts of 4-tert. butyl phenol (HOC6H4But-4) in the presence of the base, diethyl amine, in tetrahydrofuran (THF) solvent. The resulting complex was characterized by elemental analysis, molecular weight determination, molar conductance measurement, IR, and 1H NMR spectral studies. The reactivity of the newly synthesized complex (I) with HgCl2 …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 14–19 Read article
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In silico Molecular Docking Analysis of Stephania glabra phytocompounds Targeting Thymidylate Kinase for potential Antituberculosis Activity
Abstract: Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. It mainly affects the lungs and spreads through the air when a person with active TB in their lungs coughs, sneezes, or spits. This study investigates several bioactive compounds derived from plants to forecast how effective plant-based ligands will be at preventing tuberculosis. The purpose of the study was to use computational techniques to assess the effectiveness of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article
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Synthesis and Spectral Characterization of Complexes Tin(II) With 4-Nitrophenol
Abstract: Tin(II)4-nitrophenoxide complexes with the formulas SnCl(OC₆H₄NO₂-4) and Sn(OC₆H₄NO₂-4)₂ were prepared through the reaction of stannous chloride (SnCl₂) with 4-nitrophenol (HOC₆H₄NO₂-4) in 1:1 and 1:2 molar ratios, respectively. The reaction was performed in tetrahydrofuran (THF) with diethylamine serving as the base. The resulting compounds were characterized through elemental analysis, determination of molecular weight, molar conductance measurements, and spectroscopic methods including IR and ¹H NMR spectroscopy. Current investigations are directed toward assessing …
Published in International Journal of Advance in Molecular Engineering · Vol. 4, Issue 1, 2026 · pp. 22–26 Read article
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Reactivity of Monochlorotetrakis2-Isopropylphenoxoniobium(V), [NbCl(OC6H4CH(CH3)2-2)4] towards Chelating Ligands
Abstract: The niobium(V) complexes with the formula [NbCl(OC₆H₄CH(CH₃)₂-2)₄] were successfully synthesized in high yields through the reaction of niobium pentachloride with four equivalent amounts of 2-isopropylphenol in carbon tetrachloride. The synthesized complexes were characterized and confirmed by elemental analysis, molar conductance measurements, infrared (IR) spectroscopy, ^1H and ^13C NMR spectroscopy, as well as mass spectrometric analysis. The spectroscopic studies have shown these to exhibit dimeric structures bridging through isopropylphenoxo groups. The …
Published in International Journal of Minerals · Vol. 3, Issue 1, 2026 · pp. 37–45 Read article
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Study of the Antibacterial Activity of Artemisia Absinthium against E. coli bacteria Isolated from Urinary Tract Infections
Abstract: Twenty clinically diagnosed samples were collected using transport medium swabs from the operating room at Al-Amal Specialized Laboratory in Iraq between November 2025 and February 10, 2026. Antibiotic susceptibility testing was performed on the 20 Escherichia coli samples. The results showed a clear difference in the bacterial isolates' response to the tested antibiotics. Imipenem demonstrated the highest inhibition rate, reaching 24.55% (100%), compared to the other antibiotics used in the …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 17–25 Read article