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25 articles for “TSH”
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Efficacy of Combination Therapy with Osimertinib and Afatinib in epidermal growth factor receptor-mutant non-small-cell lung cancer Patients
Abstract: Treatment options for patients with non-small-cell lung cancer who have epidermal growth factor receptor mutations are constrained by the emergence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib or afatinib alone, when tested in a laboratory model, led to the formation of drug-resistant clones harboring epidermal growth factor receptor secondary mutations. However, combining these drugs prevented the emergence of such mutations. In a Phase II clinical trial, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 13–24 Read article
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Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature
Abstract: Developing data from current research reveals fresh insights into the roles played by long non-coding RNAs (lncRNAs) in immuno-oncology. Long non-coding RNAs (lncRNAs) not only influence the aggressiveness of cancer cells but also play a crucial role in controlling different immune cells and stromal cells, which in turn changes the tumor micro-environment and impacts anti-tumor immunity. The significance of predictive indicators derived from long non-coding RNAs (lncRNAs) is underscored by …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 7–26 Read article
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The Evaluation of the Light Parameters and Pleural Fluid Cholesterol to Determine the Differences Between Exudative and Transudative Pleural Discharge
Abstract: Background: Pleural effusion occurs when an imbalance between pleural fluid production and absorption leads to the accumulation of excess fluid in the pleural cavity. Pleural effusions are commonly classified into two types: transudative or exudative, depending on the underlying mechanism of fluid formation. While transudates typically result from systemic factors like heart failure or liver cirrhosis, exudates are usually caused by local factors such as infection, malignancy, or inflammation. Differentiating …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 30–35 Read article
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The Analysis of Deep Learning-Based Methods for Identifying Diabetic Retinopathy
Abstract: Diabetic retinopathy (DR) is a degenerative eye condition resulting from diabetes mellitus, where high blood glucose levels lead to lesions on the retina. This condition is considered the leading cause of blindness among working-age diabetic patients, particularly in developing countries. As the disease is irreversible, the treatment aims to preserve the patient’s current vision. Early detection is crucial for effective management of DR to maintain vision. One of the main …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 15–31 Read article
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Utilizing circulation-derived cancer cells to evaluate patients with surgically treated stages I–IIIA NSCLC throughout the preoperative phase
Abstract: Context: When a tumor is considered resectable, surgery is viewed as the primary treatment approach for both early-stage and locally advanced non-small cell lung cancer (NSCLC). One of the most exciting areas of cancer research in the past ten years is liquid biopsy, which offers a practical non-invasive method for cancer detection and tracking. Circulating tumor cells (CTCs) have been linked to a worse prognosis and increased chance of relapse …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 17–28 Read article
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A summary continuation analysis evaluating the prevalence and predictors of diabetic retinopathy in newly diagnosed type 2 diabetic patients.
Abstract: Context: Diabetic retinopathy (DR), the leading cause of acquired blindness in adults, affects approximately 93 million people globally. It is a serious complication of type 2 diabetes, resulting from prolonged damage to the blood vessels in the retina. Although largely preventable and treatable, DR continues to be the main cause of vision loss among working-age adults and significantly impacts quality of life. While most studies on DR in Nepal have …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 21–30 Read article
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Comparative Study on Thermal Performance of Mud Rammed and Concrete Residential Building Envelope in Paro - Bhutan
Abstract: A key factor in assessing the total energy efficiency of a building is the thermal performance of the building envelope. In Bhutan the building energy sector accounts for 15% of the total domestic electricity consumption out of which 50 to 60% accounts for space heating in the temperate region. Previous research findings and data also indicate that heat loss or gain through the building envelop were the most significant contributor …
Published in International Journal of Energy and Thermal Applications · Vol. 4, Issue 1, 2026 · pp. 9–16 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Pyogenic-Cerebral (Brain) Abscess
Abstract: Abscesses in the brain have been one of the most challenging wounds, both for surgeons and trainees. It is a packet full of pus of infected material in the part of the brain. It is an important neurological disease and can produce deadly diseases. Since the beginning of the era of computed tomography (CT), the diagnosis and treatment of these organizations has become simpler and less invasive. The results have …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 12, Issue 1, 2022 · pp. 33–46 Read article
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Development and Performance Evaluation of a Polyethersulfone–Graphene Oxide Ultrafiltration Membrane for Simultaneous Drug Delivery and Virus Removal: An Experimental Investigation
Abstract: The development of multifunctional ultrafiltration membranes for simultaneous controlled drug delivery and viral removal has gained considerable attention in biomedical engineering, pharmaceutical sciences, and water purification. Polyethersulfone (PES) membranes offer excellent thermal, chemical, and mechanical stability; however, their hydrophobicity can limit permeability, antifouling performance, and biocompatibility. This study proposes the fabrication of PES–graphene oxide (GO) ultrafiltration membranes using the phase inversion technique, with systematic variation of GO concentration to optimize …
Published in International Journal of Membranes · Vol. 3, Issue 2, 2026 Read article
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Population-Based Cancer Epidemiology of Sikkim, India: Incidence Patterns, Demographic Distribution, and Public Health Implications
Abstract: Background: Cancer incidence in India shows marked regional variation due to differences in ethnicity, lifestyle, environmental exposure, and healthcare access. Sikkim, a small Himalayan state with unique demographic characteristics, has been covered by a Population- Based Cancer Registry (PBCR) under the National Cancer Registry Programme (NCRP), yet detailed analytical interpretations remain limited. Objectives: To conduct an in-depth epidemiological analysis of cancer incidence in Sikkim using PBCR data, examining site- specific …
Published in International Journal of Pathogens · Vol. 3, Issue 2, 2026 Read article
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Investigation of Parameters Determining Thermosyphon Flow-Velocity in a Simulated Solar Water Heater
Abstract: Real life experimental investigations that involve natural variables are essential and necessary in determining the performance characteristics of systems that depend on them but they are not easily repeatable under the same conditions. The alternative approach is the modelling and simulation of such systems. This work however, is concerned with the experimental investigation of the performance characteristics of thermosyphon solar water heating system using an electrically simulated collector. Heating rate …
Published in Recent Trends in Fluid Mechanics · Vol. 4, Issue 2, 2017 · pp. 23–28 Read article
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Using the TCGA Database, Establishing and Validating an RNA-binding Protein-based on Prognostic Model for Liver Cancer
Abstract: Background: The third most common cause of cancer-related death is liver cancer, one of the most prevalent hematological malignancies in the world. The term RNA-binding protein (RBP) refers to a group of proteins that bind to RNA to control metabolic processes. The development of RNA-binding proteins is related to the mortality of liver cancer victims. Methods: RBP gene expression data from liver cancer were extracted using the TCGA database. The …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 2, 2022 · pp. 7–22 Read article
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Standardization of Structural and Functional Brain Integration in Cannabis Users
Abstract: Cannabis is one of the most widely used and commercialized illegal drugs worldwide, notably amid young adults. The neurobiological mechanisms of cannabis, particularly in adolescents, have yet to be identified. The purpose of the present study was to evaluate a cohort of 73 cannabis users (aged 22–36years, 19 females) and his 73 healthy controls (aged 22–36, females). We observed some momentous differences in local structural/functional network measures (such as grade …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 10, Issue 1, 2023 · pp. 1–17 Read article
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Comprehending and Managing Restless Leg Syndrome
Abstract: An need to move that arises during rest or is made worse by rest, that happens in the evening or at night, and that goes away or gets better with movement is the hallmark of restless legs syndrome (RLS), a frequent sensorimotor disease. The degree, frequency, and age of start of symptoms vary greatly; severe types can impair mood, quality of life, and sleep. Periodic leg movements are common in …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 1–6 Read article
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Finding Risk Factors in Thyroid and Cardiovascular System Using Naive Bayesian (NB) Machine Learning Technique
Abstract: Thyroid malady could be a common condition. A TSH test is carried out to check for the capacities of your thyroid organ. Illnesses of thyroid can be caused by conditions which cause thyroid organ over or under function. The test can moreover assist you recognize thyroid conditions some time recently indications happen. It is either as well (hyperthyroidism) or under-active (hypothyroidism), you might know. In case untreated, thyroid clutter may …
Published in Research & Reviews: A Journal of Embedded System & Applications · Vol. 8, Issue 1, 2020 · pp. 1–5 Read article
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Assessment of Thyroid Disorders in Pre-Diabetic Patients of South Gujarat Region
Abstract: Background: Coexistence of both thyroid disorders and pre-diabetic condition can make control of blood sugar more difficult and converting pre-diabetics into diabetic patients. Aim of the study is to assess the T3, T4 and TSH level and thyroid disorders including hypothyroidism, subclinical hypothyroidism and subclinical hyperthyroidism in pre-diabetic patients in south Gujarat region. Material and Method: The study carried out at biochemistry department SMIMER medical college using 20–60 years of …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 1, 2018 · pp. 13–20 Read article
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Assessment of Serum Enzymes Level in Patients with Thyroid Alteration Attending Manipal Teaching Hospital, Pokhara
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Thyroid hormones exert their effect on all tissue and modulate the rate of metabolic activity. Alterations in thyroid function can affect the various organ system of body and perturb measures like AST, ALT, GGT, ALP, CPK and LDH. Both hypothyroidism and hyperthyroidism have potentially fatal systemic manifestations. The main aim of study was to determine the relationship between thyroid alteration and …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 3, Issue 1, 2013 · pp. 1–9 Read article
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Serum Magnesium, Iron, TIBC, and Hormonal Imbalances in Hypertensive Pregnant Women: A Comparative Study
Abstract: Pregnancy-induced hypertension (PIH), including gestational hypertension and preeclampsia, is a leading cause of maternal and fetal complications. The regulation of blood pressure and overall pregnancy health is influenced by micronutrients and hormones. This study aimed to evaluate serum magnesium, serum iron, total iron binding capacity (TIBC), thyroid profile, and quadruple marker levels in hypertensive pregnant women and compare them to normotensive controls. Methods: A total of 1056 hypertensive pregnant women …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 41–45 Read article
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Hypokalemic Periodic Paralysis: A Rare Presenting Manifestation of Thyrotoxicosis
Abstract: Thyrotoxicosis may be related to hypokalemic periodic paralysis in young asian males. Periodic paralysis related to hypokalemia as the initial manifestation without any clinical signs and symptoms of thyrotoxicosis is exceedingly rare. Our patient is a 25-year-old male who presented with quadriparesis with respiratory distress when he woke up in the morning. There was history of high carbohydrate intake one day prior. On examination he had single breath count of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 3, 2017 · pp. 17–19 Read article