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8 articles for “Structural variants”
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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Solid Lipid Nanoparticles in Medicine: Formulation, Characterization and Future prospects
Abstract: An alternative to conventional colloidal carriers such liposomes, polymeric nanoparticles, and emulsions, solid lipid nanoparticles (SLNs) were created in the early 1990s. Benefits include targeted medicine distribution, controlled drug release, and improved stability. An extensive review of the excipients utilized, the production techniques, including the membrane contractor approach, and the possible advantages and disadvantages of SLNs is given in this work. It investigates secondary stabilization techniques like freeze-drying and spray-drying, …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 1–15 Read article
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Stretching Boundaries: A Comprehensive Review of Ehlers-Danlos Syndrome and its Subtypes
Abstract: The Ehlers-Danlos syndromes (EDS) encompass 13 inheritable disorders affecting connective tissue. These conditions arise from genetic alterations impacting the structure of connective tissue. Every variant of Ehlers-Danlos syndrome (EDS) exhibits distinct features and has specific diagnostic criteria. While certain traits such as joint hypermobility, skin hyperextensibility, and tissue fragility are common across all types of EDS. The range of clinical presentations spans from minor skin and joint looseness to severe …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 44–57 Read article
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Advancements in Energy-Efficient Electrical Motor Design: A Comprehensive Review
Abstract: The rapid growth in energy demand poses a fundamental challenge for the whole power industry in fulfilling the increased demand. An exhaustive energy audit recommends substituting energy-efficient gadgets with conventional ones, which function with low efficiency and waste a significant amount of electricity. Electric motors are quite common in contemporary life, providing energy to a wide range of devices, including both domestic and industrial machinery. Nevertheless, they bear the responsibility …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 1, Issue 1, 2023 · pp. 29–35 Read article
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Efficient Malware Detection in Cybersecurity: Leveraging Advanced Data Structures for Enhanced Threat Identification
Abstract: The cybersecurity landscape is constantly changing with more advanced malware creating major challenges for detection systems. To address these challenges effectively, advanced data structures have become essential in optimizing how data is managed, processed, and analyzed for malware detection. This review paper delves into the role of several cutting-edge data structures—bloom filters, tries, hash tables, graphs, decision trees, and suffix trees—in enhancing the efficiency and accuracy of malware detection mechanisms. …
Published in International Journal of Data Structure Studies · Vol. 2, Issue 2, 2024 · pp. 32–40 Read article
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Importance of Thesaurus in Natural Language Processing for Scholarly Data Extraction
Abstract: The exponential growth of scholarly literature needs advanced methods for efficient data extraction and knowledge discovery. Natural Language Processing (NLP) has emerged as a crucial technology in automating the analysis and organization of academic texts. Among various linguistic resources, thesauri serve as important tool for enhancing semantic understanding by providing structured vocabularies, synonyms, and hierarchical relationships between terms. This paper examines the importance of thesauri in enhancing NLP-based scholarly data …
Published in Emerging Trends in Languages · Vol. 3, Issue 1, 2026 · pp. 19–24 Read article
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Comparative Study of BERT Variants for Sentiment Analysis with Error Analysis
Abstract: The use of media is going up fast in India, and this has led to the rise of Hinglish. Hinglish is an informal blend of Hindi and English that people commonly use in everyday conversations, especially across social media platforms such as Twitter, Facebook, and WhatsApp. People use Hinglish to talk to each other in a way that is not very formal. Hinglish blends English vocabulary with informal usage, often …
Published in International Journal of Computer Science Languages · Vol. 4, Issue 1, 2026 · pp. 39–48 Read article