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11 articles for “Sickle cell disease”
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Serum Hepcidin Status of Sickle Cell Disease Subjects with Multiple Blood Transfusion in Nigeria
Abstract: Objectives: No effective physiological mechanism for excess iron excretion is known in humans. Conditions such as sickle cell disease (SCD), where red blood cell transfusion is a frequently employed therapy can subsequently result in ready accumulation and circulation of exogenous iron as non-transferrin bound iron in tissues with possible impairment of iron homeostasis in them. Aim: The influence of multiple blood transfusions on the patterns of iron homeostasis in correlation …
Published in Research and Reviews: A Journal of Medicine · Vol. 9, Issue 2, 2019 · pp. 1–9 Read article
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Prevalence of Sickle Cell Disorder in Rural Vyara of Gujarat
Abstract: Sickle cell anaemias are the most common hereditary disorders in India and pose a major health problem. The study was conducted in the population of Vyara city, taluka Vyara, district Tapi of Gujarat state, India, from July 01, 2017 to September 31, 2017. The screening was done by dithionate turbidity test. The selected people were determined, and their result was established by Hb electrophoresis. The present study was carried in …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 3, 2018 · pp. 17–20 Read article
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Outcome of the Ayurvedic medication on a patient with Sickle cell anaemia – A single case study
Abstract: Sickle cell disease is caused by genetic modification of β-globin (HBB). The result of clinical syndromes is characterized by chronic hemolytic anemia and can be complicated by vaso-occlusion and vasculopathy which can lead to severe and chronic organ damage and premature death. A 17-year-old female patient was diagnosed with sickle cell anemia with symptoms of severe weakness, shortness of breath, loss of appetite, constipation, severe calf pain, chest pain, abdominal …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2022 · pp. 1–8 Read article
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Moyamoya Disease: A Cerebral Disorder of Children
Abstract: Moyamoya disease is an increasingly recognized arteriopathy associated with cerebral ischemia and has been associated with approximately 6% of childhood strokes. It is characterized by chronic progressive stenosis at the apices of the intracranial internal carotid arteries (ICA), including the proximal anterior cerebral arteries and middle cerebral arteries. Occurring in tandem with reduction in flow in the major vessels of the anterior circulation of the brain, there is compensatory development …
Published in Journal of Nursing Science & Practice · Vol. 4, Issue 2, 2014 · pp. 58–63 Read article
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Blood Cell Saver Machine
Abstract: Intraoperative Cell Salvage (ICS) is a crucial technique in modern surgical practice aimed at minimizing the need for allogeneic blood transfusions. By collecting, filtering, washing, and re-infusing a patient’s own blood lost during surgery, ICS provides a safer and cost-effective alternative to donor transfusion, reducing the risk of transfusion-related infections and immunologic reactions. Initially conceptualized in the early 19th century, ICS technology evolved significantly with the introduction of the Cell …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 51–59 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Hemoglobin Electrophoresis to Identify Adult Hemoglobin and Abnormal Hemoglobin Bands
Abstract: According to National Thalassemia Welfare Society (NTWS) report, every year, around 3 to 4 lakhs babies are born with one or other form of hemoglobinopathies and around 7% of the world population is carrier of hemoglobinopathies. In India, hemoglobinopathies like thalassemia and sickle cell anemia, are one of the most common hereditary disorders and cause a major health problem. In India, incidence of sickle cell and β thalassemia differ from …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 12, Issue 2, 2023 · pp. 1–6 Read article
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Innovations in Gene Therapy: Revolutionizing Treatment for Genetic Disorders and Diseases
Abstract: Gene therapy is a revolutionary intervention in the treatment of genetic diseases since it is an intervention that aims at the very source of diseases, through editing and modification of genes. More recent innovations in gene editing systems, such as CRISPR-Cas9, CRISPR-Cas12, and prime editing, have greatly increased the accuracy and effectiveness of gene therapies, enabling more specific therapies. The opportunities of personalized medicine are also extended by the creation …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 19–25 Read article
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Identification and Characterization of Genetic Predictors of Sickle Cell Anemia in Bilaspur District, Chhattisgarh, India
Abstract: In the present decades, sickle cell anemia (SCA) is a challenging task for control of hereditary syndrome in Bilaspur district of Chhattisgarh state, India. The present study aims to identify and characterize genetic predictors of SCA from Bilaspur district (CG) in 2024. A total of 3000+ individuals were screened and categorized into carriers, positive (screening), and diseased cases. Fetal hemoglobin (HbF) level is determined by several genetic factors including genetic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 2, 2026 · pp. 1–9 Read article
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Oral Manifestations of Haematological Disorders (RBC Disorders)
Abstract: Haematological abnormalities are diverse in nature, in its causation as well as in its clinical manifestations, most ofwhich are exhibitedin the oral cavity. In fact,the oral site in many instances could act as the forerunner of itsmanifestations before the expression of systemic signs and symptoms. The symptoms of haematological disorders are sovaried and nonspecific but often represent the initial sign of an underlying disease. Anaemic disorders are associated with orofacial …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 1, 2020 · pp. 18–22 Read article
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Gene Therapy in Modern Medicine: Promises and Challenge in Treating Genetic Diseases
Abstract: Gene therapy is a medical approach that focuses on altering or adjusting an individual’s genes to treat or prevent illnesses. The aim is to repair faulty genes or insert new ones into the body to combat diseases. Gene therapy can involve directly introducing modified or new genes into a patient’s cells or altering the genes already present in the patient’s body. This approach shows potential for treating a range of …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 27–32 Read article