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2 articles for “SPARC”
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Architectural Evolution of RISC Processors: From Early Research Prototypes to Modern Industrial Implementations
Abstract: This paper surveys the architectural evolution of Reduced Instruction Set Computer (RISC) architectures from early research prototypes to modern industrial processors, tracing four decades of design refinement across academic, embedded, server, mobile, and open- hardware ecosystems. Core ISA principles, pipeline evolution, compiler–hardware co-design, and quantitative performance modeling are analyzed through four representative industrial implementations: MIPS 74K, SPARC T4, ARM Cortex-A72, and SiFive U74 (RISC-V). Each processor is examined in terms …
Published in Journal of VLSI Design Tools and Technology · Vol. 16, Issue 2, 2026 · pp. 29–39 Read article