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17 articles for “Phosphatase Activity”
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Production of Phosphatase by Phosphate Solubilizing Improved Fungal Strains
Abstract: Phosphate solubilizing micro-organisms were isolated from rhizosphere soils of rice fields around Mannachanalur area, Tiruchirappali district of Tamilnadu. The isolated fungal cultures were identified as Aspergillus niger, Aspergillus fumigatus and Penicillium sp. The efficacy of Phosphatase activity of fungal strains was carried out. The fungal strains were subjected to random mutational studies such as UV and chemical mutation. The Phosphatase assay was carried out after random mutagenesis using wild and …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 2, Issue 1, 2012 · pp. 39–52 Read article
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Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
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Histochemical Localization of Acid Phosphatase in the Haustoria of Two Stem Parasites Cassytha Filiformis L. (Lauraceae) and Cuscuta Reflexa Roxb. (Cuscutaceae)
Abstract: Abstract Acid phosphatases consist of a group of non-specific enzymes that hydrolyse a variety of organic esters with the liberation of phosphate ions. Sodium α-naphthol phosphate substrate is used to localise acid phosphatase activity. The activity of this enzyme was greatest at the sites of haustorial entry and in the region of the hausorial contact with the host vasculature. The presence of this enzyme at the region of interface indicates …
Published in Research & Reviews : Journal of Botany · Vol. 3, Issue 3, 2014 · pp. 1–4 Read article
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Status of Phosphatases in Basella alba L. Leaves During Water Stress
Abstract: Activity of acid phosphatase and alkaline phosphatase in the leaves of medicinally important plant Basella alba with respect to its two cultivars under water deficit and water logging stress was estimated. It was recorded that the activity of both the phosphatases increased with increase in water stresses with single exception. The increased activities probably help in release of inorganic phosphates at intracellular level that might regulate proper plant metabolism which …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 1, 2016 · pp. 6–9 Read article
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Antidiabetic and Antioxidant Activity of Leaves of Aegiceras corniculatum (L.) Blanco (Black Mangrove): An in vitro and in vivo Study
Abstract: AbstractPurpose: Aegiceras corniculatum (L.) Blanco, commonly known as Black Mangrove, is a species of shrub or tree mangrove with a distributed Indian mangrove forest and traditionally used to treat diabetes and other health ailments. Aim: The objective of this work was to enlighten the function of Indian mangrove variety of A. corniculatum leaves on carbohydrates blemishing reactions through diabetes using in vitro and in vivo methods. Methods: The aqueous leaves …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 1, 2018 · pp. 23–31 Read article
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Ameliorating Effect of Vitamin C on Acid Orange 7 Induced Oxidative Stress in the Gill of the Fish, Anabas testudineus (Bloch, 1792)
Abstract: Acid orange 7, an azo dye, was exposed to Anabas testudineus at a sublethal concentration (0.27 g/l) for 24, 72 and 96 h in order to evaluate the antioxidant status in the gill tissue. In addition, vitamin C at 0.55 g/l was exposed for 7 days after the dye exposure. Acid orange 7 decreased the body weight of fish, whereas mucous deposition increased significantly as the first line of defensive …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 15–27 Read article
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Biochemical and Kinetic Investigations of Partially Purified Thermostable Acid Phosphatases from Solanum tuberosum and Citrus limonium
Abstract: Biochemical and kinetic properties of partially purified thermostable acid phosphatases from Solanum tuberosum and Citrus limonium involving ammonium sulphate fractionation have been investigated. The maximum specific activity in Solanum tuberosum and Citrus limonium was found in 40–80% (ACP I) and 0–40% (ACP II) fractions, respectively. The specific activities of ACP I and ACP II were 46.01 and 48.00 units mg − 1 with Km values of 1.00 and 2.50 mM, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 2, Issue 1, 2012 · pp. 1–10 Read article
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Endosulfan-Induced Hepatotoxicity and its Amelioration by Administration of Bamboo (Dendrocalamus Strictus) Seed Extract in Rats
Abstract: Endosulfan is an important hepatotoxic agent that generates free oxygen radicals in liver and the incidence of toxic injury to the liver tissue in relation to its widespread has been reported. Bamboo is rich in phenolic components which possess various bioactivities and bamboo seed extract was found to have antioxidative properties. Hence, the present study has been designed to assess the protective role of bamboo seed extract against endosulfan induced …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 1–7 Read article
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3D-QSAR Studies on Protein Phosphatase 2A Inhibitors as Anti-cancer Agents
Abstract: The tremendous efforts by researcher indicates that cantharidin, nor cantharidin and their analogues shows anti-cancer activity due to their inhibition of cancer cell lines such as HT29, SW480, MCF-7, A2780, H460, A431, DU145 and L1210. The anti-cancer activities of cantharidin, nor cantharidin and their analogues involve the inhibition of serine/threonine protein phosphatises (PPs) activity. In this study, three-dimensional quantitative structure activity relationship (3D-QSAR) like comparative molecular field analysis (CoMFA), and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 1–19 Read article
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Evaluation of the anti diabetic effects of ethanolic root extract from polyalthania longifora in diabetic rats induced by streptozotin and nicotinamide with considaertion of toxocological aspects
Abstract: The root of Polialthia Longifolia was selected for the evaluation of antidiabetic potential in STZ-nicotinamide induced diabetic rat model.The root extract was extracted by hot percolation using ethanol as a solvent in soxhlet apparatus and the preliminary phytochemical screening was performed and it shows that the ethanolic root extract of Polialthia Longifolia contains alkaloids, glycosides, flavonoids and tannins. Safety profile is essential for the drugs obtained from the plant origin. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 37–50 Read article
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Hematobiochemical Alteration in Naturally Infected Cattle with Fasciola under Tropical Region
Abstract: Fascioliasis is among one of the emerging and re-emerging disease which has zoonotic importance and spread by feco-oral route. The migrating fluke causes extensive liver damage results in economic burden to the animal farmer. In present investigation 20 cattle were used to evaluate the hemato-biochemical alteration in naturally acquired fasciola infection and without other diseases. Decreased Hemoglobin, Packed cell volume (PCV), Red blood cells (RBC) count whereas; an elevated level …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 4, Issue 1, 2015 · pp. 20–23 Read article
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Hepatoprotective Efficiency of Nigella sativa L. Extract on D-Galactosamine Induced Toxicity
Abstract: The Protective role of Nigella Sativa L. alcoholic extract (NSE) was investigated on D-Galactosamine (DGalN) induced hepatotoxicity in rats. Twenty four adult wistar albino rats were divided into four groups viz Control, D-Galatosamine induced hepatotoxicity, Nigella sativa alcoholic extract and Nigella Sativa alcoholic extract pretreatment prior to the administration of D-Galactosamine. After treatment, the rats were sacrificed, blood and liver samples were collected for determination of Serum Aspartate transaminase (AST), …
Published in Research and Reviews: A Journal of Toxicology · Vol. 1, Issue 1-3, 2011 · pp. 39–44 Read article
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Sublethal Toxic Effect of Paraquat Dichloride on Tissue Biochemical Markers in Labeo rohita
Abstract: The present study investigated the sublethal toxic effect of the commercial grade herbicide, Paraquat dichloride (24% SL), on Labeo rohita stressing the importance on biochemical parameters. Fishes were exposed to the sublethal concentrations of paraquat dichloride (5 μg/l and 10 μg/l) for 24 h in treated groups. Treated groups showed highly changed biochemical parameters on their exposure to the herbicide paraquat, when compared to the control. Tissues such as brain, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 11, Issue 2, 2021 · pp. 20–28 Read article
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Computational Identification of Protein Tyrosine Phospatase-1B (PTP-1B) Inhibitors for Checking Type II Diabetes
Abstract: Protein tyrosine phosphatases (PTPs) are a family of enzyme that comprises of about 100 proteins which catalyze dephosphorylation of phosphotyrosine residues in protein substrates. Phosphotyrosine is a central element in cell signaling, and its activity is essential for cellular homeostasis and for appropriate responses to extracellular signals. PTP-1B antagonizes insulin signaling by reducing the activation state of the insulin receptor kinase, thereby inhibiting post-receptor signaling in insulin responsive tissue. The …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 6, Issue 3, 2017 · pp. 21–25 Read article
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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The Significance and Correlation of Biochemical Parameters-related to Bone Diseases
Abstract: The chemical composition, mass and property of bones are controlled by various factors which include decreased mineral intake or absorption, defects in Vitamin D absorption or activation. Bone diseases are also influenced by growth factors, estrogen, testosterone, insulin, Parathyroid, Thyroid, and Cortisol hormone. Our study handles various human blood and urine samples ranging between the ages of 25–50 years for the above mentioned parameters which include calcium, alkaline phosphatases, phosphorous, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 33–36 Read article
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An Extensive In vitro Approach in Development of Next Generation Drugs Against Trehalose-6-Phosphate Phosphatases Involved in Pathogenicity of Many Microorganisms
Abstract: Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4 AbstractTrehalose-6-phosphate phosphatase (TPP) enzymes implicated in pathogenecity of number of bacteria, fungi and nematodes causing serious diseases such as tuberculosis, candedemias, aspergillosis, elephantiasis and parasitic ones. This study is an effort to target a common pathway critical to pathogenicity of different microbes but entirely absent in vertebrates and to come out with new generation drugs by an extensive in vitro approach. …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 1, 2018 · pp. 32–43 Read article