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5 articles for “Metalloproteinases”
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Computational Exploration of Aristolochia indica Bioactive Compounds Against Snake Venom Proteins Using Docking and Dynamics Simulations
Abstract: Snakebite envenoming is a neglected health threat impacting millions of people each year especially in tropical and subtropical countries. Ethnomedicinal plants are sources of various bioactive compounds and have been utilised by several tribes across the world for centuries. Aristolochia indica is a perennial herb mentioned in the Indian Ayurveda with a long history of use against snake venom, scorpion venom, fevers, rheumatic arthritis, liver ailments, leishmaniasis etc. The major …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 1, 2026 Read article
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Rheumatoid Arthritis and Stem Cell Therapies Perspectives for It
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, primarily affecting synovial joints, leading to joint destruction and systemic complications. The pathogenesis involves immune system dysregulation, autoantibody production, and enzymatic imbalances. Enzymes, including matrix metalloproteinases (MMPs), serine proteases, and kinases, play crucial roles in these processes. Their dysregulation contributes significantly to disease progression through the imbalance of pro-inflammatory cytokines, oxidative stress, and extracellular matrix (ECM) degradation. MMPs, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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A Review on Kaempferol Eye Drops for the Glaucoma Treatment
Abstract: One of the main causes of permanent blindness, glaucoma is defined by gradual damage to the optic nerve, mostly brought on by oxidative stress, neuroinflammation, and high intraocular pressure (IOP). The investigation of herbal alternatives is necessary since current synthetic therapies, such as beta-blockers and prostaglandin analogs, frequently result in ocular discomfort, systemic toxicity, and poor patient compliance. Clitoria ternatea contains kaempferol, a bioactive flavonoid that has shown anti-inflammatory, antioxidant, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 110–121 Read article
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In Vivo Biocompatibility and Interfacial Stability of Thermoplastic Polyurethanes and Nanofilled Resin Composites: A Bioanalytical Study of Polymer-Host Interactions Under Dynamic Loading
Abstract: The widespread application of thermoplastic polyurethanes (TPU) and nanofilled resin composites in biomedical devices requires rigorous assessment of their biocompatibility under mechanical stress. While nanofilled composites utilize filler particles (<100 nm) to enhance surface properties and wear resistance, the biological response to these materials in a hydrolytic, enzymatic environment remains a critical area of investigation. Objective: To analyze the in vivo bio-molecular response at the interface of TPU aligners and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1112–1119 Read article
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Expression Profiling of Immunomodulatory Genes in Canine Adipose Tissue–Derived Mesenchymal Stem Cells
Abstract: Adipose tissue–derived mesenchymal stem cells (AT-MSC) represent a heterogeneous population of self-renewing, multipotent progenitor cells residing in the stromal compartment of adipose tissue. Canine adipose tissue-derived mesenchymal stem cells have attracted significant interest in regenerative medicine due to their therapeutic potential in naturally occurring canine diseases and their translational relevance to human medicine. In the present study, canine adipose tissue–derived MSCs (cAT-MSCs) were isolated and differentiated into osteogenic, chondrogenic and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 1, 2026 Read article