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12 articles for “MDD”
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Comparison of Index and Engineering properties of weak soils stabilized by Rubber Tyre Chips and Powder
Abstract: Engineered constructions on weak or soft ground soil carry inherent risks due to the instability of the foundation. Soft ground lacks the necessary strength to support structures adequately, making it prone to settlement, subsidence, or even collapse under the weight of buildings or infrastructure. Various methods of improvements are used to improve the soil's stability to support various loads.one of the solution is can use the waste products incorporated into …
Published in Journal of Polymer & Composites · Vol. 12, Issue 2, 2024 · pp. 24–33 Read article
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Improving Black Cotton Soil with Sodium Hydroxide and Fly Ash: An Assessment of Optimum Moisture Content, Dry Density, and California Bearing Ratio
Abstract: This study investigates the stabilization of Black Cotton Soil (BCS), an expansive clayey soil primarily composed of montmorillonite minerals, using sodium hydroxide (NaOH) and fly ash. Due to its high plasticity and significant volume changes with moisture, BCS is challenging for construction purposes. Adding NaOH and fly ash can potentially improve the soil's moisture tolerance, compressibility, and reduce its plasticity, making it more suitable for structural applications. The research evaluates …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 192–201 Read article
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Enhancing the Strength of Black Cotton Soil with Enzyme and Industrial Waste
Abstract: Expansive soils are troublesome and prone to ground movements, which can cause substantial damage to underlying buildings as well as a loss in bearing capacity. Moisture fluctuation activates the expansive character of soils, causing it to swell and shrink. This has long been known in geotechnical engineering. To treat expansive soils, a variety of stabilizing additives such as lime, cement, and fly ash have been employed. In recent years the …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 1, Issue 1, 2023 · pp. 1–11 Read article
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Utilization of Recron Fibers for Improving Subgrade Stability of Expansive Soils
Abstract: The major interest in the utilization of synthetic fibers is used as reinforcing material for developing reinforcing effect into the entire soil composition laid bellow the structures whare as construction works are going on. Various articles are published on soil reinforcement, yet some of them fibers used are prepared by using with synthetic materials, one type of synthetic fibers were Recron fiber it is used as a reinforcing element to …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 170–178 Read article
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Evaluate The Engineering Properties of Low Load-Carrying Capacity of Expansive Soil by Using Magnesium Chloride and Dry Leaf Ash Powder
Abstract: The swell-shrink behavior of expansive soils poses numerous challenges with the substructure and distress in infrastructures such as buildings, pavements, breast walls, etc. The behavior of expanding soil has been carefully examined by geotechnical engineers, who have then put adequate management techniques into place. Present investigation intends to investigate potential benefits of dry leaf ash (DLA) powder and magnesium chloride (MgCl2) to enhance geological characteristics of soil, particularly addressing problems …
Published in Journal of Geotechnical Engineering · Vol. 12, Issue 1, 2025 · pp. 33–45 Read article
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Rapid-On-Tongue Delivery: A Review of ODT Technologies, Taste Masking and Compliance
Abstract: Orodispersible Tablets (ODTs), another name for Fast Dissolving Drug Delivery Systems (FDDS), are innovative drugs that dissolve in the mouth rapidly without requiring water. These will be especially helpful for kids, the elderly, and others who have difficulty swallowing ordinary tablets or capsules. Superdisintegrants are used in these pills to break down quickly in the mouth, while flavorings or sweeteners are used to cover up any harsh or unpleasant taste. …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 01–08 Read article
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Sustainable High-Strength Geopolymer Composite Reinforced with Nano-Silica and Basalt Fibers: Mechanical and Microstructural Evaluation
Abstract: Sustainable soil composites (SSC) were formulated by incorporating red earth with varying proportions of bagasse ash (BA) and hydrated lime to enhance geotechnical performance and promote the reuse of agro-industrial waste. Red earth served as the primary structural matrix, BA functioned as a pozzolanic filler, and lime acted as a chemical stabilizer. BA content ranged from 0% to 60%, identifying 10% as the optimum level for significant improvement, and lime …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 1113–1122 Read article
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Red Earth Development of a Soil-Based Composite Using Bagasse Ash and Lime: Effects on Plasticity and Compaction Characteristics of Red Earth
Abstract: The concept of sustainable soil composites (SSC) emerges through blending red earth with bagasse ash (BA) and hydrated lime to enhance geotechnical properties and enable productive reuse of agro-industrial waste. Red earth functions as the matrix, BA acts as a fine pozzolanic microfiller, and lime serves as the chemical binder. BA content ranges from 0% to 60%, with 10% identified as optimal; subsequent lime additions from 1% to 5% evaluate …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 1147–1158 Read article