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23 articles for “Host–pathogen interaction”
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Investigating the Impact of Viral Infections on Pharmacokinetics and Pharmacodynamics of Antiviral Drugs
Abstract: The emergence and re-emergence of viral infections pose significant challenges to public health, necessitating a comprehensive understanding of how these infections impact the pharmacokinetics and pharmacodynamics of antiviral drugs. This review explores the intricate interactions between viral pathophysiology and the pharmacological effects of antiviral agents. Factors such as viral replication dynamics, host immune responses, and the genetic variability of both viruses and hosts significantly influence drug absorption, distribution, metabolism, and …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 23–30 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: Pathogens have evolved a wide repertoire of virulence strategies that allow them to invade host tissues, establish infection, and circumvent immune responses. From the initial steps of adhesion and colonization to complex molecular mimicry, antigenic variation, and immunomodulation, pathogens display remarkable adaptability. While traditional research has emphasized host cell entry and toxin production, emerging evidence highlights subtler and more dynamic strategies such as manipulation of host signaling pathways, subversion of …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Host Interface of Cystic Fibrosis and P. aeruginosa
Abstract: A clash between microbial infection and host immunity can contribute to multiple diseases. Cystic fibrosis is one of those diseases. It’s an autoimmune disorder and hyperinflammatory disease, caused by pseudomonas aeruginosa, it’s the most predominant pathogen causing this disease. The progression of the lung infection cystic fibrosis is driven by host pathogen interface that focuses on the host and the bacterial factors. The disease has an interplay between the host, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 9–31 Read article
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Host-Pathogen Coevolution: Implications for Immune Evasion and Pathogen Fitness
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 · pp. 6–10 Read article
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Insilico Structural Analysis and Homology Modeling of Crustin Protein from Fiddler Crab Species
Abstract: In terms of biomass and ecological or economic importance, the crustacea are the largest, most noticeable, and possibly, the most significance group of marine or aquatic arthropods. Because of their enormous commercial value and the necessity to prevent disease outbreaks in the shellfish aquaculture industry, decapods are the experimental animals of choice for practically all biological studies involving immune responses. Antimicrobial host-defense peptides (AMPs) are major components of metazoan immunity, …
Published in International Journal of Cheminformatics · Vol. 1, Issue 1, 2023 · pp. 1–7 Read article
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Antimicrobial Peptides in Fiddler Crabs: Structural Analysis and Potential Applications
Abstract: Crustaceans represent the largest and most ecologically and economically significant group of marine and aquatic arthropods. Their biomass and critical role in ecosystems highlight their importance. Among crustaceans, decapods are frequently used as model organisms in studies of immune responses due to their significant commercial value and the need to mitigate disease outbreaks in shellfish aquaculture. Antimicrobial host-defense peptides (AMPs) are pivotal in metazoan immunity, especially for invertebrates lacking adaptive …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 26–32 Read article
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Revolutionizing Vaccine Development:The Transformative Role of Bioinformatics in Designing Next-Generation Immunotherapies
Abstract: Vaccines have long been central to the prevention and control of infectious diseases, dramatically reducing morbidity and mortality worldwide. In the modern era, the integration of bioinformatics has revolutionized vaccine development by enabling rapid, precise, and cost-effective identification of potential vaccine targets. This seminar explores the multifaceted applications of bioinformatics in vaccinology, including antigen discovery, epitope prediction, structural modeling, molecular docking, and immunoinformatics-driven vaccine design. Special emphasis is placed on …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 3, 2025 · pp. 19–33 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 Read article
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The Invisible Engineers: How Viruses Change Cells at the Molecular Level
Abstract: Viruses are frequently thought of as simple parasites, yet at the molecular level, they are quite good at engineering and may change the way the cells they infect work. The Invisible Engineers: How Viruses Rewire Cells at the Molecular Scale looks into how viruses get into host cells, mess up intracellular circuits, and exploit molecular resources to make copies of themselves. This article talks about how viral proteins and nucleic …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 · pp. 1–6 Read article
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A Review on Diagnosis and Management of Conjunctivitis
Abstract: Conjunctivitis, typically recounted as crimson eye, is a super ocular circumstance affecting men and ladies of all ages. This abstract aims to summarize the findings of a comprehensive study that delves into the pathogenesis, clinical manifestations, and management strategies for conjunctivitis. A multifaceted approach was employed, including a systematic literature review of conjunctivitis-related studies, clinical observations, and interviews with leading ophthalmologists. The various cases were analysed to assess demographic patterns, …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 35–46 Read article
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Veterinary Immunology in Zoonotic Disease Control
Abstract: Zoonotic diseases, which are transmissible between animals and humans, pose a significant threat to global public health, food security, and economic stability. Veterinary immunology plays a pivotal role in understanding host–pathogen interactions, developing preventive strategies, and mitigating the impact of these diseases. Animals serve as reservoirs for a variety of pathogens, including viruses, bacteria, and fungi, which can persist asymptomatically or cause clinical disease. Understanding the immune mechanisms in both …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 36–43 Read article
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The Induction, Formation, and Establishment of Giant Cell in Plant-Parasitic (Meloidogyne Spp.)-Host Interactions: A Molecular and Cellular Basis
Abstract: Root-knot nematodes, (RKN) are obligatory endoparasites of over 3000 plant species, causing $70 billion in annual economic losses globally. The second stage juveniles hatch from the eggs invade the root apex and inject pathogen effectors that induce specialized feeding cell called Giants cell that are large multinucleated cell formed, due to repeated cycles of mitosis without cytokinesis and served sole source of feeding site for rootknot nematode. The ability RNN …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 34–45 Read article
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Microbial Competition in the Rumen: Insights into Fermentation Kinetics, Host Health, and Environmental Sustainability
Abstract: Microbial competition within the rumen is a crucial determinant of fermentation efficiency, nutrient utilization, and overall host health in ruminant animals. The complex microbial community in the rumen comprises bacteria, protozoa, fungi, and archaea, all of which interact in intricate and often competitive ways to degrade feed and produce essential metabolites. This competition significantly influences fermentation kinetics, determining the rate and efficiency of carbohydrate, protein, and fat breakdown. Such microbial …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 27–42 Read article
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The Role of Gut Microbiota in the Health Effects of Fermented Dairy Products
Abstract: The human gut microbiota plays a crucial role in maintaining physiological health, influencing digestion, metabolism, immune function, and even mental well-being. Among dietary interventions aimed at modulating gut microbiota, fermented dairy products have emerged as particularly promising due to their rich content of live microorganisms, bioactive compounds, and nutrients. This review explores the intricate interactions between fermented dairy products and the gut microbiota, highlighting their potential health benefits and underlying …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 2, 2025 · pp. 5–10 Read article
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Recombinant Proteins and Nested Gene Regulation: Nutrient Driven Immune Response and Disease Resistance in Livestock
Abstract: Livestock production systems are increasingly challenged by infectious diseases, metabolic disorders, and environmental stressors that reduce productivity and compromise animal health. Advances in molecular biology and animal nutrition now offer new opportunities to strengthen disease resistance through integrated strategies that combine recombinant protein technologies, gene regulatory mechanisms, and nutrient mediated immune modulation. This review examines how recombinant proteins and nested gene regulation interact to shape nutrient driven immune responses in …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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ISGylation: A Key Host Cellular Defense Mechanism
Abstract: ISGylation, a crucial process of the innate immune response, has garnered increasing attention for its involvement in host's defense against pathogenic infections as well in cancer progression. The key player of ISGylation, ISG15, is stimulated by type I interferons (IFNs). ISG15 covalently binds with viral (influenza NS1A and nucleoproteins) and host (Nedd4, filamin B and CHMP5) target proteins and this interaction inhibits the viral replication process and release of viral …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 68–80 Read article
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Demodex spp. (Acari: Demodicidae) Infestation in Humans: Diagnostic Clues and Therapeutic Approaches to Primary and Secondary Demodicosis.
Abstract: Demodicosis represents an inflammatory dermatosis and adnexal disorder arising from pathologic overgrowth of Demodex mites, primarily Demodex folliculorum and Demodex brevis, which are ubiquitous human ectoparasites residing in pilosebaceous units and eyelid margins. Once regarded as benign commensals, these mites are now recognized as primary drivers or key cofactors in diverse clinical phenotypes, including papulopustular eruptions, pityriasis folliculorum, rosacea-like disorders, blepharitis, meibomian gland dysfunction, and exacerbations of comorbid dermatoses such …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 12–20 Read article
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Nutrition Induced Gut Microbiota Modulation in Food Animals: Implications for Viral Susceptibility, Shedding and Transmission Dynamics for Sustainable Development
Abstract: The gut microbiota has emerged as a central mediator linking host nutrition, immune competence, and vulnerability to viral pathogens in food animals. Diet is a primary driver of microbial community structure and function, influencing metabolite production, intestinal barrier integrity, and systemic antiviral immunity. Accumulating evidence indicates that nutrition induced modulation of the gut microbiota can substantially alter viral susceptibility, replication, and shedding patterns, with downstream effects on transmission dynamics within …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 46–56 Read article
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Medically Important Hemiptera: Bed Bugs and Kissing Bugs in Human Health.
Abstract: Bed bugs (family Cimicidae) and kissing bugs (subfamily Triatominae) are hematophagous Hemiptera of major medical importance, yet they differ markedly in their public health impact. Bed bugs have resurged globally over the past three decades, with infestations reported from homes, multi-unit housing, hotels, transportation, and healthcare facilities in both high and low-income settings. They are not established biological vectors of human pathogens, but their bites cause pruritic papules, urticarial, and …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 41–49 Read article
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Prolonged Antibiotic Use and Reproductive Challenges in Dairy Cows: Implications for Ovarian, Uterine, and Overall Reproductive Health
Abstract: The widespread use of antibiotics in dairy farming has raised concerns regarding its potential impact on reproductive performance. Prolonged antibiotic administration can disrupt endocrine regulation, alter ovarian function, impair uterine health, and compromise overall fertility in dairy cows. This review explores the multifaceted consequences of antibiotic exposure on reproductive physiology, highlighting its effects on hormonal balance, follicular dynamics, uterine microbiota, and embryo viability. Antibiotics may induce hormonal imbalances that interfere …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 22–40 Read article