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9 articles for “Fc engineering”
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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The Rise of Fractional Calculus: Novel Applications in Engineering and Biological Systems
Abstract: Fractional calculus (FC) is an advanced mathematical framework that generalizes the classical concepts of differentiation and integration to non-integer, or fractional, orders. This extension of traditional calculus allows for the modeling of complex dynamic systems that exhibit behavior not easily captured by integer-order differential equations. Over the last few decades, fractional calculus has seen a rapid rise in popularity, particularly in applied mathematics, engineering, and biological sciences, due to its …
Published in Recent Trends in Mathematics · Vol. 1, Issue 2, 2024 · pp. 7–11 Read article
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FPGA Enabled Flight Control Unit
Abstract: The FPGA flight controller revolutionizes drone technology with unmatched stability and precision. Integrated with an IMU and advanced sensors like the MPU 6050, it ensures accurate positioning critical for reliable UAV operation. Its efficient real-time data processing and seamless sensor communication enhance performance and reliability across various conditions. This advancement sets a new standard in UAV technology, suitable for applications ranging from surveillance to disaster relief. An aircraft's flight control …
Published in Journal of Aerospace Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 19–25 Read article
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Arduino Uno-based Clap Detection Light Control System
Abstract: Lamp technology plays a pivotal role in providing illumination, enhancing various daily activities for countless individuals. The author endeavors to create a prototype tool equipped with a system capable of seamlessly toggling lights on and off, fostering efficiency and eliminating the need for physical interaction. This system enables the activation and deactivation of lights through the detection of sound generated by human movement, thus obviating the necessity to physically manipulate …
Published in Recent Trends in Electronics Communication Systems · Vol. 11, Issue 1, 2024 · pp. 32–38 Read article
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Bioinspired Nanocomposite Bone Pins: Fabrication, Evaluation, and Suitability for Orthopedic Implant Applications
Abstract: Bone tissue engineering (BTE) requires scaffolds that mimic bone’s mineral–organic composition, offering mechanical strength, bioactivity, and degradation rates compatible with regeneration. Conventional metallic implants face corrosion and toxic ion release risks, while ceramics like hydroxyapatite (HAp) are bioactive but brittle. This study reports a multifunctional hybrid scaffold combining HAp for osteoconductivity; polycaprolactone (PCL) and collagen for flexibility and biocompatibility with sodium citrate for nanoparticle dispersion, ferrocene (Fc) for catalytic bioactivity; …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 526–540 Read article
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Fabrication and Mechanical Characterization of Hybrid Natural Fiber Reinforced Composites using Ferromagnetic and Graphite Fillers
Abstract: The past few years have seen a lot of interest in the creation of hybrid natural fiber composites because of their lightweight properties, environmental friendliness and their potential use in structures. The hybrid composite laminates in the current study were produced by the hand lay-up process by blending the natural fibers with the functional filler materials. Three types of composite structures were created and these are Natural Composite Material (NCM), …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 498–511 Read article
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Troubleshooting CSS: Common Issues and Effective Solutions for Web Development
Abstract: Many modern websites suffer from bloated and ineffective stylesheets, despite the fact that CSS is crucial for user experience and web performance. The effects of CSS optimization strategies, including minification, modularization, critical CSS extraction, lazy loading, and unused rule elimination, are simulated and assessed in this study on four representative web platform types: news portals, e-learning platforms, e-commerce sites, and SaaS dashboards. Using a controlled experimental environment and common auditing …
Published in Journal of Web Engineering & Technology · Vol. 12, Issue 3, 2025 · pp. 44–57 Read article
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Experimental Assessment and Statistical Argument of Al-Si/CSA/MoS2 Hybrid Composites for Mechanical and Tribological Characteristics
Abstract: To augment the mechanical and tribological properties of Al-Si matrix composites complement with molybdenum disulphide (MoS₂) and coconut shell ash (CSA), a mixed experimental and Face-Centered Composite (FCC)strategy was employed. A liquid metallurgical method called stir casting was used to create hybrid composites with 5–15 wt.% CSA and 1–3 wt.% MoS₂. A FCC experimental design with thirty runs was used to thoroughly evaluate the materials. This design allowed for the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 792–802 Read article