Search
35 articles for “Estrogens”
-
Environmental estrogens: A silent enemy
Abstract: Throughout our lives we are exposed to environmental estrogens, from food, air, water, soil, and household products as well as probably through breast milk or during development in the womb. Environmental estrogens have endocrine disrupting activity. Many times natural plant compounds or synthetic chemicals may also disturb the endocrine system. These compounds are weaker than the estrogen naturally produced in the body. Many reproductive, developmental and other health problems have …
Published in Research & Reviews : Journal of Ecology · Vol. 10, Issue 3, 2021 · pp. 22–26 Read article
-
Effects of Estrogen on the Environment
Abstract: A very major and serious concern nowadays is that estrogen has become one of the most emerging pollutants. The three types of estrogens namely Estrone (E1), Estradiol (E2) and Estriol (E3), pose serious threats to plants, different sources like water, and also to humans worldwide. In past some years, they have gained attention due to rapid increase in soil and water concentration throughout the world. There have been great concerns …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 10, Issue 3, 2020 · pp. 12–17 Read article
-
In Silico Study on Estrogens Receptor Modulators as Anti-cancer Agents
Abstract: The clinical selective estrogen receptor modulator tamoxifen is most commonly used drug for the treatment of estrogen positive breast cancer and has been preventing lives worldwide. The pioneering drug; tamoxifen used in both treatment and prevention of estrogen positive breast cancer and also addressing new research for selective estrogen receptor modulators (SERMs). Based on these for current study 20 tamoxifen derivatives has been designed for in silico study. For the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 41–54 Read article
-
Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
-
Computational Molecular Docking Studies to Design Novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)-1H- indol-5-ol Derivatives for Estrogen Receptor Alfa in AF-2 Domain
Abstract: The present manuscript describes the designing of novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)- 1H-indol-5-ol derivatives as specific estrogen receptor alfa modulators and their screening by docking studies to determine the binding interaction for the best-fit conformations in the binding site of the ERα receptor. Based on the results of docking studies, the selected ligands reveal the all- important functional groups of the ligands that interact with active amino acid residues in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 15–49 Read article
-
Molecular Docking of Abroma augusta Phytocompounds Against Estrogen Receptor Alpha (Er-Α) for the Treatment of Menstrual Disorders
Abstract: Menstrual disorders, including dysmenorrhea (painful menstruation), amenorrhea (absence of menstruation), and irregular menstrual cycles, significantly impact women’s reproductive health and overall well-being. These conditions often arise from hormonal imbalances, inflammation, and uterine dysfunction, necessitating effective therapeutic interventions. Current treatments, such as hormonal therapies (oral contraceptives, progestin-only pills), NSAIDs, and surgical procedures (endometrial ablation, hysterectomy), provide relief but often target symptoms rather than addressing the underlying causes. Consequently, there is a …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 1–12 Read article
-
Virtual Screening of Novel 2-substituted -5-hydroxy-1- (2-methyl-3-morpholinopropyl)-1H-indole-3- carboxamide Derivatives for Estrogen Receptor alpha in AF-2 domain for effective Anticancer Treatment
Abstract: Present manuscript describes designing of novel 2-substituted -5-hydroxy-1-(2-methyl-3- morpholinopropyl)-1H-indole-3-carboxamide derivatives as specific ERα modulators, discuss the selection criteria for 1ERR, several interactions between the ligand and the amino acid residues that would probably elicit fruitful modulation of the receptor. Accordingly, a ligand was observed to yield Gscore of -10.016 which was found comparable with the standard ligand Raloxifene (-11.869). The present work has been designed to discover some novel 2-substituted …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 2, 2025 · pp. 31–55 Read article
-
Tamoxifen: Role in Breast Cancer Treatment
Abstract: Breast cancer is one of the most common cancers among women worldwide. In the last two decades, there have been various therapies proposed for the treatment and prevention of breast cancer. One of them is targeted hormonal therapy (THT) for the estrogen and its receptor in breast cancer. The synthetic selective estrogen receptor modulator, tamoxifen is in the use for treating, estrogen receptor-positive breast cancer from the last 30 years. …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 1, 2016 · pp. 1–19 Read article
-
RsaI polymorphisms of ER-β and Idiopathic Male Infertility
Abstract: Purpose: Study on association between estrogen receptor gene polymorphism and male infertility has been interested, but highly specific genetic markers have been reported to be variable according to regions and nations. Herein we studied to figure out whether ERβ gene1082 G>A polymorphism could influence on sperm indices or not.Method: We dealt with 100 Korean patients with idiopathic male infertility diagnosed at our university hospital as a study group and 127 …
Published in Research and Reviews: A Journal of Medicine · Vol. 12, Issue 3, 2022 · pp. 34–41 Read article
-
A Review of Literature on Breast Cancer: Molecular Insights, Clinical Approaches, and Future Perspectives
Abstract: Breast cancer is the leading cause of morbidity and mortality in women globally. Although both men and women can get the condition, women are more likely to get it, and its prevalence has been rising globally in recent years. The epidemiology, risk factors, pathophysiology, diagnosis, treatment options, and survival rates of breast cancer are all examined in this review of recent research. Breast cancer can show up as a lump …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 15–20 Read article
-
The Effects of Propylparaben on Women with Respect to Breast Cancer: A Study
Abstract: Propylparaben is a natural substance found in many plants and some insects; although it is manufactured synthetically for the industrial applications in field of cosmetics, pharmaceuticals, foods and so on. It is used as a preservative, typically found in many water-based cosmetics, commercially available pharmaceuticals and foods items, such as creams, lotions, shampoos, bath products, tablets, baked food products and so on, to reduce the activity of microorganisms. Parabens have …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 2, 2018 · pp. 38–43 Read article
-
Brief Review on Novel Technology in Breast Cancer Chemotherapy
Abstract: Breast cancer is cancer that develops from breast tissue. Breast cells contain receptors for the two types of hormones estrogen and progesterone. They also contain receptors for a protein called HER2, which induce normal cell growth. Around two out of three women with breast cancer have cells that bear receptors for estrogen and progesterone, and just about 20–30% of breast cancers have too many HER2 receptors. Exploitation chemotherapy to treat …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 2, 2018 · pp. 22–26 Read article
-
A Short Review on Breast Fibroadenomas
Abstract: Breast Fibroadenomas are the most common type of benign breast lumps found mainly in adolescent women. These are unilateral, smooth, demarcated, rubbery, mobile, and painless masses. They are believed to be formed by the influence of changes in the female reproductive hormone, estrogen and sometimes the combination of both estrogen and progesterone which mainly occurs at the time of puberty. Fibroadenomas are mostly found in women till the age of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 2, 2022 · pp. 8–14 Read article
-
Menopausal Syndrome-Facts, Causes, Symptoms, Complications and Its Management with Unani Herbal Medicines: An Overview
Abstract: AbstractMenopause is generally defined as cessation of periods for 12 months or as time of cessation of ovarian function resulting in permanent amenorrhoea. Menopause normally occurs between the ages of 45 and 55 years; the average being 47 years. Menopause is thus a gradual and natural transitional phase of adjustment between the active and inactive ovarian function and occupies several years of a women’s life and involves biological and psychological …
Published in Research & Reviews : Journal of Herbal Science · Vol. 3, Issue 2, 2014 · pp. 1–10 Read article
-
A Review on Medicinal Properties of Chickpea and Its Profile
Abstract: Cicer arietinum is the most well-known vegetable and seen everywhere in the world, particularly in Afro-Asian nations. It has a place with family Fabaceae and appropriated in tropical, sub-tropical and calm districts. It is an annual crop with 20–100 cm tallness and the stems are spread, erect while root framework is vigorous and leaves are made of 11–15 individual handouts which are oval fit as a fiddle. The blossoms are …
Published in Research and Reviews : Journal of Crop science and Technology · pp. 1–11 Read article
-
Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
-
Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
-
A Surgical Perspective on the Physiology of the Female Reproductive System: Exploring Oogenesis and Ovulation
Abstract: The female reproductive system serves as the cornerstone of both familial and societal well-being, underlining the importance of women's health and understanding the physiology of their reproductive system. At the core of this system lie various organs dedicated to crucial functions. The ovaries, for instance, play a central role in producing the ova or eggs necessary for reproduction. These eggs travel through the fallopian tubes, facilitated by the uterus, to …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 49–55 Read article
-
RP-HPLC method for simultaneous determination of Drospirenone and Ethinylestradiol in Bulk and their Pharmaceutical dosage form
Abstract: Oral contraceptive is used to prevent the pregnancy which is contain hormones to block the release of eggs from the ovaries. Most of them contain estrogen and progesterone. Nowadays, usage of hormonal contraceptive is sharply enhancing; around 100 million of women worldwide are taking these drugs. With this drug fertility rate can be supressed as long as they want or plan their activity along with these drugs provide efficacy, reliability, …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 46–67 Read article
-
A Comprehensive Review of Literature on Endometriosis: Pathophysiology, Diagnosis, and Management
Abstract: The endometrium, a tissue that resembles the lining of the uterus, develops outside the uterus in endometriosis, a chronic and frequently painful illness. Other parts of the body may also be affected, however the ovaries, fallopian tubes, and the tissue lining the pelvis are the most frequently affected. Infertility, heavy menstrual flow, and pelvic pain are the main signs of endometriosis, though each person may experience these symptoms to varying …
Published in International Journal of Midwifery Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 1–5 Read article