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18 articles for “De-escalation”
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The Burden of Empirical Therapy: Analyzing the Predominance of Broad-Spectrum Antibiotic Usage in Lower Respiratory Tract Infections
Abstract: Lower respiratory tract infections (LRTIs) remain one of the leading causes of morbidity and hospitalization worldwide, particularly among older adults, immunocompromised individuals, and patients with chronic respiratory disorders. These infections include conditions such as community-acquired pneumonia, hospital-acquired pneumonia, bronchitis, and acute infective exacerbations of chronic lung disease, all of which often require rapid clinical intervention. Because microbiological confirmation of the causative pathogen frequently takes 48–72 hours, clinicians generally initiate empirical …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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Unveiling the Silent Threat: The Escalation and Defence Against Antibiotic Resistance
Abstract: The global challenge of antibiotic resistance presents a significant risk to public health, driven by multifaceted factors worldwide. This issue, akin to the impacts of climate change, requires concerted efforts at national and international levels to mitigate its consequences. Antibiotics have revolutionized modern medicine, enabling critical interventions like surgeries, transplants, and cancer treatments. However, without global collaboration, we face significant setbacks across medical, social, and economic domains. Initiatives to address …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–26 Read article
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Evaluating the Role of Pharmacists in Managing Antibiotic Use and Combating Multi-Drug Resistance in Hospital Settings
Abstract: Antibiotic resistance is now one of the crucial health issues of the world, especially in hospitals where high usage of antimicrobials is increasing the rate at which multi-drug resistant (MDR) organisms appear. Misprescription, extended treatment, and over-use of broad spectrum antibiotics play a large role in the development of resistance resulting in the growth of morbidity, mortality and health care expenditure. This review analyses the essentiality of pharmacists in controlling …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 12–19 Read article
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Demodex spp. (Acari: Demodicidae) Infestation in Humans: Diagnostic Clues and Therapeutic Approaches to Primary and Secondary Demodicosis.
Abstract: Demodicosis represents an inflammatory dermatosis and adnexal disorder arising from pathologic overgrowth of Demodex mites, primarily Demodex folliculorum and Demodex brevis, which are ubiquitous human ectoparasites residing in pilosebaceous units and eyelid margins. Once regarded as benign commensals, these mites are now recognized as primary drivers or key cofactors in diverse clinical phenotypes, including papulopustular eruptions, pityriasis folliculorum, rosacea-like disorders, blepharitis, meibomian gland dysfunction, and exacerbations of comorbid dermatoses such …
Published in International Journal of Insects · Vol. 3, Issue 1, 2025 · pp. 12–20 Read article
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White-Rot Fungi-Based Bioprocessing for Circular Bioeconomy & Valorization of Lignocellulosic Waste
Abstract: The escalating global demand for sustainable resource management and the imperative to reduce dependence on fossil-based products have positioned the circular bioeconomy as a transformative paradigm for the 21st century. Lignocellulosic biomass, generated abundantly as agricultural and forestry residues, constitutes one of the most underexploited renewable carbon sources on Earth, yet its recalcitrant structure, interlinking cellulose, hemicellulose, and lignin, has long impeded its efficient valorization. White-rot fungi (WRF), predominantly belonging …
Published in International Journal of Fungi · Vol. 3, Issue 2, 2026 Read article
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Bioethanol and Beyond: A Comprehensive Review on Sustainable Biofuels for Global Energy Demands and Environmental Conservation
Abstract: This comprehensive review explores the concept of "biofuels," specifically focusing on energy-enriched chemicals generated through biological processes or derived from the biomass of living organisms, including microalgae, plants, and bacteria. As the global population continues to increase, there is a growing demand for more energy supplies to enhance the quality of life. Biofuels, harnessed from various sources such as sugar, starch, and organic waste, have emerged as potential solutions to …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 1–9 Read article
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Impacts of Climate Change on Land Degradation: A Review of Mitigation
Abstract: Land degradation has emerged as one of the most pressing environmental challenges globally, significantly impacted by the multifaceted and escalating effects of climate change. The degradation of land, including soil erosion, nutrient depletion, deforestation, and desertification, directly threatens food security, biodiversity, and human livelihoods. As climate change leads to increasingly erratic weather patterns, including prolonged droughts, intense rainfall, and extreme temperatures, land degradation has become more pronounced and widespread, exacerbating …
Published in International Journal of Land · Vol. 2, Issue 1, 2025 · pp. 6–10 Read article
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The Dual Crisis: Antibiotic Resistance and the Discovery Void – A Review of Novel Therapeutic Strategies and Non-Traditional Approaches
Abstract: The global rise of antimicrobial resistance (AMR) has emerged as one of the most critical public health challenges of the 21st century, threatening to undermine decades of therapeutic success and rendering conventional antibiotic regimens increasingly ineffective. Parallel to the escalating resistance rates is a profound “discovery void,” characterised by a steep decline in the development of new antibiotic classes since the late 20th century. Together, these two interconnected crises create …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 47–65 Read article
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The Impact of Sleep Quality on Academic Performance and Burnout Among College Students
Abstract: In today’s academic environment, college students face a multitude of challenges that disrupt their well-being—one of the most overlooked being sleep quality. While balancing coursework, social obligations, and personal goals, sleep often becomes a casualty of the student lifestyle. Many students often sacrifice sleep without fully realizing how it affects their mental sharpness and emotional well-being. This study delves into the complex connection between how well students sleep, how they …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 59–65 Read article
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Predictive Analytics for Student Well-Being and Occupational Success
Abstract: The integration of predictive analytics into higher education has significantly transformed institutional decision-making processes. However, prevailing implementations remain predominantly performance-centered, focusing on dropout prediction and grade forecasting rather than holistic developmental outcomes. Concurrently, higher education systems worldwide are confronting escalating concerns regarding student mental health, disengagement, career uncertainty, and labor market volatility. These intersecting challenges necessitate a broader theoretical reconceptualization of predictive analytics—one that integrates psychological well-being and long-term occupational …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 155–163 Read article
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A Comprehensive Review on Monkeypox Infection
Abstract: Monkeypox represents a zoonotic viral affliction instigated by the monkeypox virus, which is classified within the Poxviridae family and is distinct from the virus that causes chickenpox. Initially recognized in 1958, this infection has recently attracted international scrutiny due to its escalating incidence beyond traditional endemic territories. This review delivers an exhaustive examination of monkeypox, encompassing its epidemiology, viral morphology, modes of transmission, pathogenesis, clinical presentations, and therapeutic interventions. The …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 23–32 Read article
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The Role of Land Use and Housing Laws in Mitigating Climate Change Effects
Abstract: This study explores the crucial role of land use and housing laws in mitigating the effects of climate change, focusing on how urban planning, zoning regulations, and building codes can drive sustainable, climate-resilient development. As cities worldwide face the dual challenges of rapid urbanization and escalating climate risks, land use policies offer significant potential for reducing greenhouse gas emissions and enhancing adaptation to climate impacts. The paper examines strategies such …
Published in International Journal of Land · Vol. 1, Issue 2, 2024 · pp. 35–40 Read article
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A Trends in Dietary Supplement Related to Exercise Nutrition
Abstract: A product made to address physiological or nutritional demands that might occur during sports activity is called a dietary supplement. It could offer a convenient method for fulfilling specific nutritional needs during exercise, or it could be utilized to prevent or address common nutritional deficiencies experienced by athletes. It is crucial to include the supplement in a thorough plan for the best possible sports nutrition or clinical care of nutritional …
Published in International Journal of Nutritions · Vol. 1, Issue 2, 2024 · pp. 1–6 Read article
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Influence of Antibiotic Promotion Practices on Pharmacovigilance and Resistance Reporting Patterns
Abstract: The global escalation of antimicrobial resistance (AMR) has emerged as a critical public health crisis, undermining decades of therapeutic advancements. While inappropriate prescribing and misuse of antibiotics are widely acknowledged contributors, the role of pharmaceutical promotion practices remains underexplored in influencing prescribing behaviors and downstream pharmacovigilance systems. This review critically examines how antibiotic promotion strategies – ranging from direct physician engagement to digital marketing – affect adverse drug reaction (ADR) …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 1–11 Read article
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Persistent Atmospheric and Ecosystem Impacts of Enteric Methane Emissions from Intensive Livestock Production Systems
Abstract: Enteric methane emissions from intensive livestock production systems exert a significant long-lasting influence on atmospheric stability and ecosystem integrity. Recent observations confirm that global methane emissions continued to rise through the early 2020s, with total emissions exceeding 620 teragrams per year by 2024, driven by expanding ruminant production and associated feed systems. Anthropogenic sources accounted for more than 330 teragrams per year, reflecting sustained growth in agricultural and fossil fuel …
Published in International Journal of Atmosphere · Vol. 2, Issue 2, 2025 · pp. 18–38 Read article
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Nutritional Status, Bioactive Properties & Therapeutic Efficacy of Omega-3 Polyunsaturated Fatty Acids Obtained by Green Synthetic Routes
Abstract: Polyunsaturated fatty acids (PUFAs), particularly omega-3 (n-3) fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are crucial for human health. They support structural brain development, visual acuity, and cardiovascular function, while also exhibiting potent anti-inflammatory, antioxidant, and antimicrobial properties. Historically, marine fish oil has been the primary dietary source of these essential fatty acids. However, escalating concerns regarding ecological environmental impacts, the oceanic bioaccumulation of heavy metal contaminants, …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article
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Antimicrobial Peptides and Bacteriophages as Next-Generation Alternatives to Conventional Antibiotics
Abstract: The growing threat of antibiotic-resistant bacteria has underscored the urgent need for innovative alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) and bacteriophages are gaining recognition as next-generation therapeutics due to their distinct mechanisms of action and ability to target resistant pathogens effectively. AMPs, which can be natural or synthetic, disrupt microbial membranes and offer broad-spectrum antimicrobial activity with a reduced likelihood of resistance development. Bacteriophages, as bacteria-specific viruses, provide precise …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 9–27 Read article
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Gut Microbiome Dysbiosis During Metabolic Disorders: Diabetes
Abstract: Understanding the intricate interplay between gut microbiome dysbiosis and diabetes is crucial due to the escalating prevalence and impact of diabetes mellitus globally. This comprehensive review examines the current understanding of this relationship, elucidating how alterations in the gut microbiome composition contribute to diabetes pathogenesis by influencing metabolic homeostasis, immune regulation, and insulin resistance. Dysregulation of gut microbial communities leads to shifts in diversity and abundance, exacerbating chronic low-grade inflammation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 56–75 Read article