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3 articles for “DNA cleaving activity”
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Synthesis, Structural Characterization and Biological Studies of Schiff Base Complexes Bearing Indole Moiety
Abstract: Schiff base complexes of N2O2 type derived from indole-3-carboxaldehyde(ind) and amino acids such as glycine(gly), L-valine(val), and L-tryptophan(try) with Cu(II), Ni(II), Zn(II), Co(II) and Mn(II) were synthesized and characterized by physical and analytical techniques. The complexes are of non-electrolytic nature having 1:2 (metal:ligand) ratio. The geometry of the complexes was predicted with the combined data obtained from electronic spectral and magnetic susceptibility measurements. The mode of coordination of the Schiff …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 4, Issue 1, 2013 · pp. 31–42 Read article
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DNA Binding and Cleavage Studies of Cobalt Complexes Containing Bioactive Mixed Ligands
Abstract: The complexes containing bioactive ligand of the type [Co(L1L2)] (PF6)2 complex (1) (where L1=1,10-phenanthroline and L2 = N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (almotriptan) in 1:1 molar ratio of ligands) and [Co(L1L3L4)] (PF6)2 complex (2) (where L3=4H-1,2,4-triazol-4-amine, L4=1H-benzimidazole-2-thiol and the ligands are in the ratio 1:1:1, were synthesized and characterized. The DNA binding property of the complexes with calf thymus DNA has been investigated using absorption spectra, viscosity measurements and thermal denaturation experiments. The intrinsic …
Published in Emerging Trends in Chemical Engineering · Vol. 1, Issue 1, 2014 · pp. 49–56 Read article
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Designer Zinc Finger Nuclease: A Versatile Tool for Genome Editing in Animals
Abstract: In this review, is provided an update on the most popular approaches, including zinc finger nuclease (ZFN)-based gene editing by homologous recombination (HR), gene knockout, non-homologous end joining (NHEJ), and gene therapy in mouse. Zinc finger nucleases (ZFNs) are synthetic restriction enzymes evolved by fusing zinc finger that facilitate genome editing by creating a double-stranded break in DNA at a user-specified location. ZFNs are new tools that promise to radically …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 4, Issue 1, 2014 · pp. 24–30 Read article