Search
109 articles for “Candidate gene”
-
Study of Polycystic Ovary Syndrome (PCOS) with Special Reference to Candidate Genes
Abstract: The PCOS (polycystic ovary syndrome) has become a worldwide concern as progression of PCOS in the age group of adolescence to postmenopausal women is increasing. In India, sudden rapid growth in PCOS is observed in the range of 3.7–22.5%. Effects of PCOS are not only on the reproductive and metabolic systems, but the whole body’s metabolism gets affected; ultimately, it leads to different life- style diseases like type 2 diabetes …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 49–55 Read article
-
Breeding and Genetics of Disease Resistance in Poultry and Farm Animals: A Review
Abstract: Disease resistance is one of the most essential parameters that is now getting consideration in the animal selection along with production traits. Development and rearing of genetically disease resistant stocks is the newer face of animal husbandry at present. The increasing microbial resistance, increased drug residues in animal products, ever increasing cost of therapeutic treatment, and consumer’s preference towards organic products are all giving bright signal to the development of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 10, Issue 1, 2021 · pp. 1–7 Read article
-
A Bioinformatics Approach for the Identification of Genes Responsible for Biofilm Formation in Candida Species
Abstract: Candida biofilm is one of the attributes for drug resistance in candidiasis. Candida biofilms are found on prosthetics, catheters, and implanted devices leads to biofouling. Genes such as ALS1, CDR1, ERG11, HWP1, LIP4 and WOR1 code for biofilm. In this study, bioinformatics tools have been used for data mining and analysis of genes responsible for biofilm formation in Candida tropicalis. Genes responsible for biofilm were tabulated via PubMed search, based …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 79–87 Read article
-
A Study of Mining High Utility Itemset
Abstract: Cost effective exploitation of a transactional database refers to the procedure of choosing the transaction sets with most cost effective features that will improve overall incomes of a company. A plethora of data mining algorithms have been recommended in the past few years to focus on mining item sets with high utility value. The word utility is about that feature of item-sets. Thus, mining algorithms tries to find out all …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 2, Issue 3, 2015 · pp. 21–25 Read article
-
Candida auris—An Emerging Superbug
Abstract: Fungi are eukaryotic organisms that are found everywhere on Earth. Usually, the optimum conditions that are required for a fungus to grow are acidic pH range of 3–4 and temperature of 25–35 °C. But recently, researchers have found some strains of fungi that are sensitive to acidic pH and low temperature of 25–35 °C whereas they are resistant to basic pH and high temperature. These strains include the species of …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 11, Issue 3, 2021 · pp. 1–6 Read article
-
Genetic Variability and Significance of STAT Gene in Dairy Animals
Abstract: Abstract Importance in the bovine signal transducer and activator of transcription (STAT) gene has increased due to involvement of STAT1 in the development of the mammary gland and regulating the transcription of genes involved in milk protein synthesis and fat metabolism in lactating dairy animals. Signal transducer and activator of transcription gene are a family of cytoplasmic proteins that are stimulated in response to a large number of growth factors, …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 5, Issue 3, 2016 · pp. 1–6 Read article
-
Generative AI for Designing Sustainable Polymer Composites for Renewable Energy Applications
Abstract: Sustainable polymer composites are increasingly required for renewable energy devices, yet conventional trial-and-error formulation cannot efficiently balance performance, processability, recyclability, and environmental constraints. This study proposes a generative artificial intelligence framework for designing polymer composites for photovoltaic encapsulation, dielectric energy storage, polymer electrolytes, and thermal-management systems. Public polymer-property and composite datasets were curated from open databases and published supplementary records. Chemical descriptors, molecular fingerprints, polymer embeddings, processing variables, and sustainability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1232–1257 Read article
-
Generative AI-Driven Design Optimization of Lightweight Polymer Composites for Electric Vehicles
Abstract: Lightweight polymer composites are increasingly important for electric vehicles, where mass reduction must be achieved without compromising structural performance, thermal stability, manufacturability, or material reliability. This study develops a generative AI-driven inverse-design framework for identifying experimentally credible lightweight polymer-composite configurations under coupled EV-oriented constraints. Public experimental polymer-composite datasets were integrated through leakage-controlled preprocessing and group-aware validation. A multi-task neural surrogate predicted mechanical response, while a conditional variational autoencoder explored feasible …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
-
Amplification of 16s rRNA Gene of Brucella melitensis Causing Brucellosis Isolated from the Aborted Fetes of Goat
Abstract: ABSTRACTBrucella melitensis is zoonosis caused by facultative intracellular bacteria of genus Brucella, which are widely distributed in both human and animals, especially in developing world. The diagnosis of goat brucellosis requires isolation of the bacteria from stomach contain aborted fetes of goat. However cultural sampling sensitivity often low, depending on the disease stage, Brucella species, culture medium, quantity of circulating bacteria and blood culture technique employed. The development of PCR …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 9, Issue 1, 2020 · pp. 8–12 Read article
-
Genetics of Bipolar Disorder: A Review
Abstract: Bipolar disorder is a complex psychiatric condition that is thought to have a significant genetic component. This article explores the genetic basis of bipolar disorder, including the potential genetic risk factors and the biological mechanisms that contribute to the development of this disorder. The article discusses the various genetic studies that have been conducted to identify genes and genetic variants associated with bipolar disorder, including genome-wide association studies (GWAS) and …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 10, Issue 1, 2023 · pp. 23–28 Read article
-
Significance of Butyrophilin Gene in Relation to Milk Constituents in Dairy Animals
Abstract: Abstract Butyrophilin (BTN1A1) has been classified as member of transmembrane proteins of immunoglobulin family. BTN1A1 is a QTL candidate gene having role in milk production and composition (fat) in dairy animals. The gene product BTN1A1 has function during secretion of milk fat and its expression is tissue specific in lactating mammary tissue. Butyrophilin gene constitutes of a more than 40% by weight of total protein and synthesized as a peptide …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 6, Issue 1, 2017 · pp. 24–30 Read article
-
Pharmacogenomics: Unlocking the Genetic Basis of Drug Response for Precision Medicine
Abstract: Pharmacogenomics, a fusion of pharmacology and genomics, explores how genetic variations influence individual responses to medications. This field is revolutionizing modern medicine by moving away from a one-size-fits-all approach toward personalized treatment strategies. By identifying specific genetic markers, pharmacogenomics aims to enhance drug efficacy, minimize adverse drug reactions, and improve overall patient outcomes. Key methodologies in this discipline include candidate gene analysis, genome-wide association studies, and haplotype analysis, all of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
-
Significance of TE Domain and Genetic Variations in FASN Gene in Dairy Animals
Abstract: The interest in the bovine fatty acid synthase (FASN) gene has increased during the last few years. FASN is a multifunctional enzyme that catalyzes de novo biosynthesis of long-chain saturated fatty acid, and alteration of this enzyme may affect economic traits including fatty acid composition. FASN is involved in fat metabolism and is an important candidate gene affecting fat composition of milk because of its central role in de-novo lipogenesis …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 3, 2016 · pp. 33–38 Read article
-
Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
-
Graph Neural Networks for Molecular Scale Property Prediction and Inverse Design of Thermoset Polymer Nanocomposites: A Computational Framework
Abstract: Thermoset polymer nanocomposites exhibit properties that are highly sensitive to molecular scale formulation decisions, yet the vast design space remains largely unexplored because of the high cost of experimental characterisation and fully atomistic simulation. This paper presents TNC GNN, a dual mode graph neural network framework developed for the computational design of thermoset nanocomposite formulations. The forward module employs an attention augmented Message Passing Neural Network with 3D geometric encoding …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
-
Generative AI-Based Inverse Design of Sustainable Biodegradable Polymers with Target Mechanical and Thermal Properties
Abstract: The escalating global plastic pollution crisis has intensified the urgent need for sustainable biodegradable polymer alternatives that can match or exceed the performance of conventional petroleum-based plastics while minimizing environmental impact. However, traditional polymer discovery approaches are severely constrained by high experimental costs, protracted development cycles spanning years, and fundamental inability to simultaneously optimize multiple conflicting material properties such as mechanical strength, thermal stability, and degradation kinetics. This study presents …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1285–1295 Read article
-
Utilizing bioinformatics to identify human diseases
Abstract: Human sickness is an alteration to a person's normal state that interferes with or changes vital functioning. Before discussing human sickness, it is important to understand what is meant by the phrases “health,” “physical fitness,” “illness,” and “disease.” Theoretically, health may be described in terms of specific measured values; for instance, a person with normal body temperature, pulse and breathing rates, blood pressure, height, and weight, as well as sharpness …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 2, 2022 · pp. 28–30 Read article
-
Scanning Electron Microscopy of Candida albicans Cell Wall on Tooth Surface after Fluconazole-Treated and Incubated with Guava (Psidium guajava L.)
Abstract: The cell wall of Candida albicans is a target of fluconazole. The content of guava (Psidium guajava L) is known to contribute factors to resistance of fluconazole.Objective: To characterize the surface alterations and the general shape changes of Candida cells after in vitro exposure to fluconazole and guava.Material and Methods: Six tooth specimen groups—Cells exposed without fungicidal doses (negative control), Positive cells exposed to maximal fungicidal doses of Fluconazole (100 …
Published in Research and Reviews: A Journal of Dentistry · Vol. 8, Issue 3, 2017 · pp. 10–17 Read article
-
Tri-Band Edge-Cut Rectangular Microstrip Patch Antenna on Composite Substrate for RF Energy Harvesting in IoT Networks
Abstract: The increasing use of Internet of Things devices underscores the pressing need for sustainable energy solutions, since traditional batteries necessitate regular replacement and constrain scalability. Radio frequency energy harvesting is a viable option; nonetheless, antenna design continues to provide a significant problem owing to the requirements for compactness, efficiency, and multi-band functionality. A hybrid composite substrate configuration combining FR4 (εr = 4.3) and RT Duroid (εr = 2.2) is employed …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 867–883 Read article
-
Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article