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13 articles for “COX 2 inhibitor”
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Design And Evaluation Of Meloxicam Tablet For Colon Cancer
Abstract: Meloxicam, recognized as a preferential COX-2 inhibitor, has emerged as a promising chemopreventive agent for colorectal cancer. Leveraging its local and targeted action on the colon, Meloxicam proves to be a formidable component in the prevention of colorectal malignancies. This study aims to innovate by formulating and evaluating a targeted tablet delivery system for Meloxicam, emphasizing site-specific and instant drug release in the colon, thereby maximizing its therapeutic efficacy in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 3, 2023 · pp. 1–7 Read article
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In Silico Study of Curcumin-Sugar Conjugates as Dual Inhibitors on Both COX-1 and COX-2 Enzymes for the Discovery of Anti-inflammatory Agents
Abstract: Curcumin is a polyphenolic compound well known for its anti-inflammatory properties. The aim of the study was to design some novel curcumin derivatives that are water soluble as well as good anti-inflammatory agents with fewer side effects. In silico study was performed on the proteins by using three softwares iGEMDOCK, AutoDOCK, AutoDOCKVina as dual inhibitors for both COX-1 and COX-2. The result gives us theoretical contribution for understanding the ligand-protein …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 1, 2017 · pp. 25–30 Read article
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A Nascent Step towards the Discovery of New Generation Non-Steroidal Anti-inflammatory Agents (NSAIDs): Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies of Some Chromene Derivatives as Potential Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors
Abstract: The current computational research profoundly focuses on the comprehensive based exploration of the anti-inflammatory potential of some novel chromene derivatives against major anti-inflammatory mediators by the utilization of the induced-fit docking (IFD) method of Schrodinger software along with pharmacokinetic profile exploration. The study will positively open new pharmacodynamic applications and avenues as anti-inflammatory agents in the future. Keywords: Anti-inflammatory, chromene, COX-2, docking, LOX, pharmacokineticsCite this ArticleTomy Muringayil Joseph, Debarshi Kar …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 2, 2018 · pp. 30–36 Read article
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Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies of Two Phenanthrene Compound Series as Potential Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors: Edema Reducing Prospects of the Emerging Candidates
Abstract: The existing explorative study involved determining the anti-inflammatory potential of two inter-linked series of phenanthrene compounds against vital targets such as cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) by induced fit docking (IFD) technique, employing the Glide module of Maestro 9.1 software. In addition to it, the comprehensive pharmacokinetic parameters (all 33 critical aspects) were determined using the QikProp module. The study opened avenues for developing …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 3, 2018 · pp. 1–8 Read article
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Anti-inflammatory Potentials of Various Oxine Compound Series as Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors: Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies
Abstract: The present investigation is an exploration of multiple oxine series in inhibiting crucial anti-inflammatory targets such as cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) by employing the Glide module of Maestro 9.1 software for induced fit docking (IFD). The study also focuses in exploration towards the essential pharmacokinetic parameters (QPlogPo/w, QPlogS, predicted aqueous solubility, QPPCaco, QPPMDCK, and percentage of human oral absorption). The study highlighted the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 16–23 Read article
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In Silico Induced-Fit Molecular Docking and Pharmacokinetic Investigations of Pentacyclic Compounds as Promising Inhibitors of Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX)
Abstract: The current search involves the discovery of cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) inhibitory potentials of some pentacyclic macromolecules by employing the Maestro 9.1 software where Glide module was utilized for the induced-fit docking (IFD). In addition to it, the critical pharmacokinetic aspects such as QPPMDCK, QPlogPo/w, % human oral absorption, QPPCaco, and QPlogS were estimated. The study fruitfully opened the therapeutic pharmacodynamic perspectives and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 13–17 Read article
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The Therapeutic vade mecum of Green Tea
Abstract: Green tea has achieved a remarkably impressive healing, or curative reputation in the West —more so, in recent times. The herb is replete with a historical legacy as a safe, effective anti-inflammatory, analgesic, and antioxidant agent. Research has shown that green tea has the ability to reduce arthritic pain, including the risk of certain forms of cancer. Other studies suggest that green tea has the ability to stabilise blood lipids—this …
Published in Trends in Drug Delivery · Vol. 5, Issue 3, 2018 · pp. 22–30 Read article
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The Therapeutic Repertoire of Turmeric
Abstract: ABSTRACTTurmeric has been used in the treatment of arthritis, and other inflammatory conditions, for ages. Its healing constituent, curcumin, has been found to curb the incendiary activity of the COX-2 and lipooxygenase, the two enzymes involved in elevating and sustaining inflammation. It is also suggested that curcumin has a protective effect on the liver, thanks to its anti-tumour resolve, aside from its ability to easing inflammation and combating infections. This …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 2, 2018 · pp. 1–9 Read article
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Herbal Coxibs: Nature’s Aspirin
Abstract: Pain is part and parcel of most health conditions from joint disorders to cancer. This explains why several researchers were hooked on to unraveling the deep puzzle behind the pain mechanism and finding a better way to relieving it with medicines that went far beyond killing pain alone. When a landmark outcome emerged and identified prostaglandins, the body’s chemical messengers, as the cause of inflammation, or pain, and that they …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 3, 2015 · pp. 13–22 Read article
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Molecular Docking Analysis of Punica granatum Compounds as Potential Inhibitors for Colorectal Cancer-Associated Molecular Targets
Abstract: Objective: Cancer is one of the most common worldwide disease which threat the life of a person. Colorectal cancer is one of the common cause of death nowadays. As computation approach is now employed for new drug discovery, target protiens like CDK-2, matrix metalloproteinase 2 (MMP-2), cyclin A, poly (ADP- ribose) polymerase (PARP-1) and Cox2 were chosen to perform molecular docking against the derivatives of Punica granatum phtyochemicals and Food …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 28–42 Read article
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5-Lipoxygenase and Phospholipase A2 Inhibitory Potentials of Alcoholic Extract of Cyperus rotundus: In vitro and In silico Study
Abstract: The literature revealed that not much reports are known for the anti-inflammatory activity of any Cyperus rotundus plant part (or extract) with respect to the molecular targets (inflammatory mediators) like cyclooxygenase-1/2 (COX-1/2), 5-lipoxygenase (5-LOX), and phospholipase A2 (pLA2). The present investigation involved exploration of in vitro inhibitory potential of alcoholic extract of C. rotundus rhizome against two important inflammatory mediators; 5-LOX and (porcine) pLA2. In addition to it, the role …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 2, 2018 · pp. 1–5 Read article
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Candida albicans: In vitro Inhibition of Morphological Transition by Analgesic Compounds
Abstract: This study aimed to investigate, in vitro, the effect of some analgesic compounds, which inhibit the activity of cyclooxygenase isoenzymes, on the morphological transition of Candida albicans from unicellular budding yeast to a filamentous form. C. albicans ATCC 10231 cultured in Sabouraud’s dextrose broth supplemented with 20% human serum for 72 h at 30 °C in the presence or absence of tramadol of HCl, ketorlac tromethamine, piroxicam and acetaminophen at …
Published in Research and Reviews: A Journal of Medicine · Vol. 3, Issue 3, 2013 · pp. 11–15 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article