Search
8 articles for “Buoyancy”
-
Controlled Drug Delivery of Furosemides Using Floating Tablet System
Abstract: The development of gastroretentive drug delivery systems (GRDDS) has gained interest, particularly for drugs like furosemide with narrow absorption windows in the upper gastrointestinal (GI) tract. Furosemide, a commonly used diuretic, faces challenges due to limited bioavailability and rapid elimination, requiring frequent dosing and affecting patient compliance. This review highlights the formulation and evaluation of floating furosemide tablets as an effective strategy to enhance therapeutic efficacy. Floating tablets allow prolonged …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 23–31 Read article
-
Balloon Deployment Strategies for Projectile Deterrence
Abstract: This paper presents a defense strategy inspired by historical precedents, aimed at neutralizing subsonic projectiles using a swarm of balloons filled with explosive and buoyant gases, such as hydrogen. The balloons are arranged in a swarm to effectively intercept multiple incoming projectiles. Numerous military and security uses are possible for them. Operating costs for lighter-than-air aircraft are lower than those of traditional fixed-wing aircraft. Lighter-than-air vehicles can be made less …
Published in Recent Trends in Fluid Mechanics · Vol. 11, Issue 3, 2024 · pp. 25–29 Read article
-
Development of Sodium Alginate Beads of Telmisartan Using Emulsion Gelation Method: Formulation and In-Vitro Characterization
Abstract: Introduction: The antihypertensive medication Telmisartan (TEL) is a member of BCS class II, which is distinguished by limited oral rate and extent and water solubility. By localizing the medication release in the stomach, gastro-retentive floating bead devices may be able to address the issues related to partial absorption and the low solubility of TEL. The preparation of TEL floating alginate beads was the aim of this investigation. The current work …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 13–21 Read article
-
Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System
Abstract: An in-depth exploration of the transformative shift underway in gastro-retentive drug delivery, spotlighting the utilization of Floating Drug Delivery Systems (FDDS) and specifically honing in on the innovative formulation strategies and mechanisms inherent in Floating In Situ Gel Raft Forming Systems. FDDS present a promising avenue for revolutionizing drug delivery efficacy by capitalizing on buoyancy to float atop the gastric fluid surface, thereby extending gastric residence time and improving drug …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 9–21 Read article
-
CFD Analysis of Double Diffusion Rotating Flow in a Cylindrical Annular MHD Braking System with Joules Heating and Dufour Effects
Abstract: The present study has investigated Joules parameter significance on an axisymmetric whirling flow within a cylindrical annulus, specifically focusing on an MHD braking system. The cylindrical annulus braking system is packed lithium lid liquid (Pr = 0.015), aspect ratio = 2, and imposed to an axial heat and magnetic field. In this study, the modified MAC pressure correction method has been used to solve the mixed convection flow with double …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1448–1462 Read article
-
The Onset of Rayleigh-Bénard-Marangoni Convection in a Ferromagnetic Fluid Layer
Abstract: This study examined the implications of magnetic boundary conditions, which are vertical in nature, on buoyancy and surface tension–driven ferrothermal convection (FTC) in a ferrofluid layer. While the upper surface is stress-free and susceptible to general thermal boundary issues, the bottom surface is stiff and insulating against temperature changes. The eigenvalue issue is solved analytically using the regular perturbation method and numerically using the Galerkin technique. According to analysis, raising …
Published in Journal of Experimental & Applied Mechanics · Vol. 16, Issue 1, 2025 · pp. 1–9 Read article
-
Effects of Hydrotherapy Programmes on Knee Osteoarthritis
Abstract: Osteoarthritis (OA) of the knee is a progressive degenerative disorder characterized by the breakdown of articular cartilage, joint margins, and surrounding structures. It is one of the most common musculoskeletal conditions affecting weight-bearing joints, leading to functional limitation, pain, stiffness, and reduced quality of life. Although OA is irreversible, early intervention and appropriate therapeutic strategies can slow its progression and help delay invasive procedures such as total joint replacement. Hydrotherapy …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 18–22 Read article
-
Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article