Search
5 articles for “Artemisinin”
-
CRISPR-Based Enhancement of Secondary Metabolites in Artemisia annua: Focus on Artemisinin Biosynthesis
Abstract: Medicinal plants are natural biofactories producing secondary metabolites with significant therapeutic value, including terpenoids, alkaloids, and phenolics. Among these, artemisinin, a sesquiterpene lactone from Artemisia annua L. is the cornerstone of global antimalarial therapy along with additional anticancer, antiviral, and antimicrobial activities. However, artemisinin content in the native plants is inherently low (typically 0.01–0.8% dry weight), restricting affordable and consistent supply. Conventional approaches to increase production include classical breeding, singlegene …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 2, 2026 · pp. 23–35 Read article
-
Trends of Antimalarial Resistance in Ethiopia and its Challenge on Malaria Control Program
Abstract: Antimalarial drugs resistance is one of the major obstacles for malaria control and curtails the life-span of several drugs. Resistance to well tolerated and effective antimalarial drugs such chloroquine and sulfadoxine-pyrimethamine (SP) has forced the switch of national policies to artemisinin-based combination therapy (ACT) for the treatment of falciparum malaria. The emergence of less sensitive clones of Plasmodium falciparum to the ACT drugs, shortly after its deployment, has posed a …
Published in Research and Reviews: A Journal of Medicine · Vol. 6, Issue 1, 2016 · pp. 38–44 Read article
-
In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus.
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology Read article
-
In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 2, 2021 · pp. 1–9 Read article
-
Role of Natural Immunity Boosters
Abstract: Our immune system has the capacity to hit upon dangerous microorganisms and viruses that input our frame—those cells, additionally called antigens, assault them with the aid of using producing ‘antibodies’. Therefore, it is far vital to take immunity booster ingredients to reinforce the frame in opposition to COVID-19 infections. A movement or substance makes something more potent or extra effective. In scientific phrases, a booster dose is a supplementary dose …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 1, 2022 · pp. 16–22 Read article