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4 articles for “Amyotrophic lateral sclerosis”
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Structure based pharmacophore Modelling of compounds against Neurodegenerative disorder – Amyotrophic Lateral sclerosis
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle dysfunction, paralysis, and eventually death. These diseases are classified as ALS variations because autopsies reveal abnormalities in both upper and lower motor neurons. These disorders account for only 10% of all adult-onset motor neuron disease cases. Despite extensive research efforts, effective therapeutic interventions for ALS remain limited. Structure-based pharmacophore modeling …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 1–17 Read article
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Dysarthria and Dysphagia in Amyotrophic Lateral Sclerosis: A Case Study
Abstract: Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease affecting the bulbar, limb and respiratory muscles. ALS is generally characterized by progressive degeneration of both upper motor neuron (UMN) and lower motor neuron (LMN) dysfunction leading to a ‘mixed’ spastic-flaccid dysarthria. To date, only a few studies have been published regarding the nature of speech characteristics and dysphagia during the developmental course of ALS. The present study highlighted …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 10, Issue 3, 2020 · pp. 12–19 Read article
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Speech Profile of Myasthenia Gravis: Case Study
Abstract: Complex coordination in muscles of articulation was supported by number of separate neural events which is large and with an amazing degree of neural integration in motor system [1]. If any point along the pathway from the cerebrum to the muscle gets damage, then the motor system which controls the speech production may be spotted [1]. Difficulty in controlling the muscles responsible for speech is called Dysarthria. Mixed dysarthria, is …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 2, 2019 · pp. 11–13 Read article
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Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases
Abstract: Curcuma longa (turmeric), a perennial herb notably utilized in traditional medication, has garnered big clinical attention due to its major bioactive compound, curcumin. Curcumin, well-known shows a couple of organic activities, together with antioxidant, anti-amyloidogenic, and neurodegenerative effects, making it a promising candidate for the management of neurodegenerative diseases (NDDs), which include Alzheimer’s illness, Parkinson’s disorder (PD), Huntington’s sickness (HD), and amyotrophic lateral sclerosis (ALS). This evaluate consolidates current findings …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 24–32 Read article