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223 articles for “structural analysis”
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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An Exploratory Investigation into the Understanding of Keratoconjunctivitis Among Staff Nurses at SCPM Hospital in Gonda
Abstract: Background: The primary aim of the present research was to evaluate the comprehension of keratoconjunctivitis among SCPM Hospital staff nurses in Gonda. Methodologically, the study was grounded in the general system theory proposed by Ludwig von Bertalanffy in 1968. To fulfill this aim, a non-experimental descriptive research design was utilized. The study included a sample of 40 SCPM Hospital staff nurses in Gonda who met the predefined inclusion criteria. Purposive …
Published in International Journal of Community Health Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 10–14 Read article
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
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Awareness, Behavior, and Gaps: A Survey-Based Analysis of Personal Hygiene, Home Safety, and Road Safety Practices
Abstract: Personal hygiene and public safety remain two of the most critical yet behaviorally neglected pillars of community health in India. Despite decades of national health campaigns, a persistent gap continues to exist between what people know and what they actually do — particularly among urban youth. This cross-sectional, survey-based study examined awareness levels, behavioral practices, and compliance gaps across three interconnected domains: personal hygiene, home accident prevention, and road safety, …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 65–72 Read article
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The Heat of Competition: Assessing Climate Vulnerabilities and Adaptive Governance in Endurance, Winter, and Youth Sports
Abstract: Background: Climate change is fundamentally reshaping the environmental parameters of global sport, posing unprecedented risks to athlete health, safety, and performance. As rising temperatures, frequent extreme heat events, and deteriorating air quality become the new normal, athletic environments from community fields to elite international arenas face an existential threat. Purpose: This study provides an interdisciplinary synthesis of the multifaceted impacts of climate change on athletes, integrating evidence from sports medicine, …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 · pp. 9–17 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Comparative Study of BERT Variants for Sentiment Analysis with Error Analysis
Abstract: The use of media is going up fast in India, and this has led to the rise of Hinglish. Hinglish is an informal blend of Hindi and English that people commonly use in everyday conversations, especially across social media platforms such as Twitter, Facebook, and WhatsApp. People use Hinglish to talk to each other in a way that is not very formal. Hinglish blends English vocabulary with informal usage, often …
Published in International Journal of Computer Science Languages · Vol. 4, Issue 1, 2026 · pp. 39–48 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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Zolmitriptan Mouth Dissolving Tablets: Development of Formulas and Invitro Evaluation
Abstract: Pharma Burst ODT super disintegrants were used in different concentrations to manufacture Zolmitriptan fast dissolving tablets by a direct compression method. With a 28° angle of repose, there is good flow. The densities for bulk and tapped materials are 0.410 (g/ml) and 0.500 (g/ml), respectively. The compressibility index and Hausner ratio have values of 19.05 and 1.24, correspondingly. According to IP standard, weight variation test results range from 121.4 mg …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 1–15 Read article
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In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
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Revitalizing São Cristóvão: Integrating Industry, Commerce, and Community for a Sustainable Urban Future
Abstract: This paper introduces a comprehensive framework for the sustainable regeneration of São Cristóvão, a historically industrial district in Rio de Janeiro, South America, which presently demonstrates significant urban deterioration, socio-economic instability, and increasing environmental hazards. Through an interdisciplinary methodology integrating spatial analysis, ethnographic profiling, environmental assessment, and stakeholder engagement, the study develops a phased master plan aimed at transforming the neighborhood into a resilient, inclusive, and economically diverse urban environment. …
Published in International Journal of Urban Design and Development · Vol. 4, Issue 1, 2026 · pp. 58–68 Read article
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Matching Minutiae Fingerprint Q-Learning Approach for Detail Coordination: Identifiable Mark Point
Abstract: The use of fingerprints for high-precision recognition and identification of people is one of the most reliable biometric symbols because it is non-invasive. In this paper, we propose an innovative approach to detect details on low contrast resolution image quality of fingerprint images. Existing algorithms are not very susceptible to sound and image excellence due to the lack of level of intensity. We recommend a reliable route to find fingerprints …
Published in International Journal of Information Security Engineering · Vol. 1, Issue 1, 2023 · pp. 1–15 Read article
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Pharma Guard: Smart Medication Management System
Abstract: Pharma Guard Smart Medication Management System presenting a comprehensive overview of an innovative technology designed to revolutionize medication management in healthcare settings. In an era of advancing digital solutions, the Pharma Guard system offers a sophisticated approach to ensuring medication safety and adherence. Through the integration of smart technology, including internet of things (IoT) devices and machine learning algorithms, Pharma Guard enables real-time monitoring, tracking, and management of medication consumption …
Published in International Journal of Mobile Computing Technology · Vol. 2, Issue 1, 2024 · pp. 30–37 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Strategies for Flood Mitigation
Abstract: The world has always experienced change. Water-too much or too little is the most common cause of migration and a city's downfall. The notable and significant distinction right now is that we are seeing it in real-time for the first time in human history. We contributed to the dangers that were produced, and we contributed to the remedies that will influence the pace and scope of change and disruption. We …
Published in International Journal of Rural and Regional Development · Vol. 1, Issue 1, 2023 · pp. 1–9 Read article
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Phubbing, Social Anxiety and Perceived Control in Young Adults
Abstract: This study examines the complex interactions among ten empirical studies on social anxiety, phubbing (phone snubbing), and perceived control. Psychological research has focused a great deal of attention on social anxiety, which is characterized by the fear of being negatively evaluated in social situations. Phubbing, the practice of people prioritizing their phones over interpersonal interactions, has become more common in recent years due to the widespread use of smartphones. This …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 18–25 Read article
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Struggles Against Displacement: A Case Study of Nilgiri Tribes TODA
Abstract: This research explores the displacement faced by the Nilgiri tribes of southern India, examining both historical and contemporary contexts. Historically, the Nilgiri tribes, including the Todas, Kotas, and Kurumbas, have lived in the Nilgiri Hills for centuries, maintaining distinct cultural practices and agricultural traditions. However, the onset of British colonial rule in the 19th century marked the beginning of their displacement, as the British established tea plantations, appropriating tribal lands. …
Published in International Journal of Rural and Regional Development · Vol. 3, Issue 2, 2025 · pp. 39–49 Read article
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A study on Antibiotic Resistance: An Analysis of Molecular Mechanisms and Therapeutic Implications
Abstract: Antibiotic resistance (AR) represents one of the most critical existential threats to global public health, rapidly eroding the efficacy of established antimicrobial therapies and portending a return to the pre-antibiotic era. This analysis explores the intricate molecular landscape defining this crisis, focusing specifically on the primary mechanisms of action (MoA) utilized by major antibiotic classes—including cell wall inhibitors, protein synthesis inhibitors, and nucleic acid synthesis inhibitors—and the corresponding, diverse mechanisms …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 9–21 Read article
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A Comparative Analysis of Factors Contributing to Relapse in Alcohol and Opioid Dependence Among Patients Admitted to Selected Hospitals in Ludhiana, Punjab.
Abstract: Introduction: Substance abuse involves the dangerous or detrimental use of psychoactive substances, such as alcohol and illegal drugs. The use of these substances can result in dependence syndrome, which encompasses a range of behavioral, cognitive, and physiological effects that arise from ongoing substance use. Objectives: This study was carried out to examine the factors linked to relapse in alcohol and opioid dependence among patients admitted to selected hospitals in Ludhiana, …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article