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217 articles for “pathogenic infection”
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Revolutionizing Vaccine Development:The Transformative Role of Bioinformatics in Designing Next-Generation Immunotherapies
Abstract: Vaccines have long been central to the prevention and control of infectious diseases, dramatically reducing morbidity and mortality worldwide. In the modern era, the integration of bioinformatics has revolutionized vaccine development by enabling rapid, precise, and cost-effective identification of potential vaccine targets. This seminar explores the multifaceted applications of bioinformatics in vaccinology, including antigen discovery, epitope prediction, structural modeling, molecular docking, and immunoinformatics-driven vaccine design. Special emphasis is placed on …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 3, 2025 · pp. 19–33 Read article
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Chemical Composition Quantification of Components in Extracts of Uncaria tomentosa by HPLC and LC-MS Analysis
Abstract: The tropical medicinal vine known as cat's claw, Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), is native to the Amazon rainforest and other regions of South and Central America. It has been shown to be useful as an immune system booster, antioxidant, antibacterial, and anti-inflammatory agent and has been historically used to treat wounds, fever, urinary tract infections, abscesses, and asthma. U. tomentosa contains a variety of phytoconstituents, including …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 1, 2023 · pp. 32–39 Read article
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Audiological Profiling in identical Twins with Auditory Neuropathy Spectrum Disorder: A Case Report
Abstract: Congenital or late-onset auditory neuropathy spectrum disorder (ANSD) is a severe form of sensorineural hearing loss primarily affects speech perception. However, there are various etiologies, including birth-related risk factors such as prematurity, hyperbilirubinemia, a genetic infant admitted to neonatal intensive care unit (NICU), anoxia, congenital anomalies, consanguinity, and other infections. A genetic predisposition is likely to be the underlying causative factor in about 40% of cases. It can be inherited …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 12, Issue 3, 2022 · pp. 25–29 Read article
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Next-Generation Biorepositories: Accelerating Infectious Disease Research and Vaccine Innovation
Abstract: Next-generation biorepositories have emerged as critical infrastructure for advancing infectious disease research and accelerating vaccine development. By integrating cellular, genomic, and clinical data within harmonized frameworks, these repositories overcome traditional limitations of fragmented datasets and limited interoperability. The evolution from conventional biobanks to digitally enabled, multi-omics platforms has enabled comprehensive analysis of pathogen–host interactions, facilitating the identification of novel vaccine targets and correlates of protection. The COVID-19 pandemic underscored the …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 Read article
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Prevalence of Urinary Tract Infection among Suspected Female Patients Attending Manipal Teaching Hospital, Pokhara, Nepal
Abstract: Urinary tract infection (UTI) is a serious health problem affecting millions of people, commonly females, each year around the world. UTI is defined by a combination of clinical features or symptoms and the presence of bacteria in urine or presence of more than 100,000 CFU/mL after urine culture. Clinical symptoms of UTI include frequency, dysuria, abdominal pain, back pain, fever, and urgency. Diagnosis of UTI relies on both urinalysis and …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 2, 2013 · pp. 20–32 Read article
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Phyto Biotics in Aquaculture
Abstract: This paper aims to assess the existing knowledge on the use and effects of phytobiotics in fish farming, as well as their potential for broader application in aquaculture. With the rising demand for fish, there has been a noticeable decline in fish production in recent years, which could be a driving factor behind the increasing interest in using phytobiotics in this field. The main factor contributing to the decrease in …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 2, 2024 · pp. 18–22 Read article
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Applications of nanotechnology in Agriculture
Abstract: Nanotechnology is expected to open new way by making a very significant impact on the world’s economy, industry and people’s lives. With the increased globalization of agricultural and food industry, there is a necessity of a developed and innovative tool to restructure the agricultural and food industry through diagnosis and treatment of diseases, enhancing the ability of plants to absorb nutrients and resist microbial and pest infectionsusing the aspects of …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 8, Issue 1, 2018 · pp. 20–27 Read article
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Negative Pressure Wound Therapy and Intermittent Irrigation with Systemic Antibiotic Suppression followed by One-stage Revision in Delayed Periprosthetic Hip Infection Cases: Reinfection Rate
Abstract: Background: Success rate of one-stage revision remains controversial in patients with delayed periprosthetic joint infection after primary cementless hip arthroplasty. We evaluated the reinfection-free efficacy of negative-pressure wound therapy (NPWT) and intermittent pulsatile irrigation (IPR) using chlorhexidine/povidone iodide combined with systemic antibiotic suppression (SAS) followed by one-stage exchange procedure with NPWT in those patients. Materials and Method: Reinfection rate was assessed in randomly selected forty-two cases (group A) with NPWT-IPR-SAS …
Published in Research and Reviews : Journal of Surgery · Vol. 11, Issue 2, 2022 · pp. 7–15 Read article
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Review on Effect of the Chemical Composition of some Pharmaceutical Vaccines and their Biochemical Efficacy with Chemical Techniques
Abstract: Chemical compounds are fundamental components in the formulation of medicines and vaccines, playing a critical role in ensuring their safety, stability, and effectiveness. Vaccines contain a combination of active and inactive ingredients, including weakened or inactivated viruses or bacteria, toxins, preservatives, stabilizers, adjuvants, antibiotics, and minerals. The active ingredient is an antigen, which stimulates the body's immune system to recognize and defend against specific infectious diseases. Adjuvants, such as aluminum …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 2, 2026 · pp. 01–09 Read article
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Canine Ehrlichiosis and Its Diagnostic Techniques: Review
Abstract: Canine monocytic ehrlichiosis, caused by Ehrlichia canis is one of the important immuno-suppressive infectious vector-borne diseases of dogs. Importantly, canine ehrlichiosis can be caused by different Ehrlichia species, which are intracellular rickettsial organisms belonging to the order Rickettsiales and included in the family Rickettsiaceae. Ehrlichias are the obligate intracellular organisms that affects the host immunologic response. It is typically a disease of leukocyte and platelet manifested by an acute reduction …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 1, 2020 · pp. 1–11 Read article
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Development and Applications of a Simple Chalcone- Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coli
Abstract: Abstract Inspired from the available biological data of several imperative therapeutic scaffolds in several medicinal chemistry databases, thiophene-containing chalcone compounds were identified and the molecule was designed for treating various nosocomial infections. In one of the recent rational exploration, (E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one was synthesized in a single-step reaction, characterized comprehensively by using a few sophisticated spectroscopic instruments such as FT-IR spectroscopy, mass spectroscopy, and 1H-NMR spectroscopy, as well as CHN analyzer, and …
Published in Research and Reviews: A Journal of Medicine · Vol. 10, Issue 2, 2020 · pp. 14–18 Read article
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Understanding Airborne Pathogens: Pathways, Risks, and Control Strategies
Abstract: Airborne transmission is the transfer of germs through the air, mostly by respiratory droplets and aerosols that come out when you cough, sneeze, talk, or breathe. These particles can stay in the air for a long time and move a long way, especially in small or poorly ventilated places. Mycobacterium tuberculosis, measles virus, varicella-zoster virus (chickenpox), influenza virus, and more recently, SARS-CoV-2 are all infections that can be spread through …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Exclusion of Seed Sprouts Salmonella Pathogens Through Bacteriophages
Abstract: Foodborne pathogens are contamination in foods; it results in poisoning conditions that reach to the consumers. Food poisoning responsible microbial inhabitants are progressive within a short duration and it is difficult to control their ascendancy. In practice, many chemical-based antimicrobial agents are used to control the foodborne pathogenic bacteria, subsequently with some drawbacks. Hence, we urgently need an attractive alternative to reduce bacterial food contamination. The lytic bacteriophages are the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 73–80 Read article
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Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article
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Emerging Therapies in Respiratory Tract Infections: Current Advances and Future Perspectives
Abstract: The impact of respiratory tract infections (RTI) as a global public health problem continues to be high morbidity and mortality rates. The development of novel therapeutic approaches stemmed from the fact that conventional treatment strategies, antibiotics, antivirals, antifungals etc. have become increasingly ineffective because of rise of antimicrobial resistance (AMR). Next generation therapies, such as novel antimicrobial agents, host directed therapies and novel drug delivery systems have come on the …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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Antibacterial Activity of Pongamia pinnata Leaf and Callus Extracts against Microorganisms Causing Periodontal Diseases
Abstract: Some specific microorganisms have been identified as etiologic agents of periodontitis. The main goal of treatment is to control the spread of infection. Depending on the extent of the gum disease, treatment varies. Therapeutic antibiotic along with surgery are the most opted form of treatment. But, due to high costs of antibiotics, the disastrous side effects and emergence of multi drug resistant strains of these pathogenic bacteria, a safe alternative …
Published in Research and Reviews: A Journal of Dentistry · Vol. 3, Issue 2, 2012 · pp. 1–7 Read article
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Artificial Intelligence in Microbiological Research: Methods, Applications and Implications
Abstract: Artificial Intelligence (AI) is revolutionising microbiological research by enabling the rapid analysis of complex biological data and improving the accuracy, efficiency, and reliability of scientific investigations. Recent advances in machine learning, deep learning, and bioinformatics have transformed AI into a powerful tool for studying microorganisms, their genetic composition, evolutionary patterns, and interactions with hosts and the environment. AI-driven computational models can process large and complex datasets far more efficiently than …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 2, 2026 · pp. 22–36 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Exploring the properties and extraction of neem leaves
Abstract: Neem (Azadirachta indica) is a versatile medicinal plant, for its diverse therapeutic properties. This abstract provides a comprehensive overview of recent research focusing on phytochemical analysis, biochemical characterization, and antimicrobial susceptibility testing of Neem extracts. Utilizing the different from of chemical used in it, phytochemical analysis identified a plethora of secondary metabolites within Neem, including alkaloids, flavonoids, terpenoids, steroids, saponin, tannins, quinone, and phenolic compounds, indicative of its complex chemical …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 32–39 Read article
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Defensive Mechanisms and Key Strategies with Its Specified Role in Mulberry Silkworm (Bombyx mori L.)
Abstract: Silkworms (Bombyx mori L.) possess a variety of defense mechanisms that play a vital role in protecting them against microbial infections and environmental stressors. These defense systems are primarily innate, relying on cellular and humoral responses. Cellular defenses include hemocytes which are responsible for processes like phagocytosis, encapsulation, and nodule formation. Humoral responses involve the production of antimicrobial peptides (AMP’s), such as cecropins, moricins, and lysozymes, which target invading pathogens. …
Published in International Journal of Insects · Vol. 1, Issue 2, 2024 · pp. 10–14 Read article