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469 articles for “derivatives”
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Pharmacoinformatic Based Screening Of Phytocompound Epigallocatechin Gallate To Identify As A Potential Bcl-2 Inhibitor
Abstract: Objectives: The B-cell lymphoma-2 (Bcl-2) is a protein that is particularly though to be involved in preventing apoptosis. Bcl-2 family members also essential for cancer survival, and its over expression has been linked to tumor genesis, development and resistance to anticancer treatments. The Bcl-2 family of members that inhibit apoptosis is a promising target for the creation of anticancer drugs. Methods: The study was based on computational approach using different …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Zen-Inspired Interior Design in Residence
Abstract: ‘Zen’, a word derived from Buddhist philosophy indicates meditation, peacefulness, and harmony with natural elements. Zen-Inspired-Interior-design has commonly been used in Chinese and Japanese homes for several years but is now growing in popularity across several countries. Japanese interiors have several characteristics, the most important of them being minimalism i.e., using simple, lowlying furniture and a neutral colour palette with less ornament or heavy patterns and emphasis on functionality. It …
Published in International Journal of Urban Design and Development · Vol. 1, Issue 1, 2023 · pp. 01–16 Read article
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Influence of Crystallization Time by Hydrothermal Synthesis of Ag NPs-Zeolite Composite
Abstract: Inorganic molecules undergo a chemical reaction that results in the production of a brand-new building material known as geopolymer concrete. Otherwise known as an inorganic aluminohydroxide polymer, geopolymer is made mostly from by-products like fly ash and geologically derived silicon (Si) and aluminium (Al). It is a superior building material for the future because of its great mechanical qualities, significant chemical resistance (attack by magnesium or sulphate), low shrinkage and …
Published in Journal of Polymer & Composites · Vol. 11, Issue 1, 2023 · pp. 46–51 Read article
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Exploration of 5-Hydroxybowdichione Flavonoids As Inhibitors of Dengue Virus Ns5 RNA-Dependent RNA Polymerase Using Molecular Docking Approach
Abstract: Objectives: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). Aedes aegypti mosquitoes, which reproduce in still water, are the primary vectors of the arboviral virus known as dengue. It is well-recognized that phytochemicals have a high potential to eliminate bacterial, viral, and fungal infections in people. Thus, it demonstrates its inhibitory effects on the dengue virus. This study identifies some …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 1–16 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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A Novel Approach to Fingerprint Authentication Using Histogram Oriented Gradients for Feature Extraction and Machine Learning Convolution Neural Network for Classification
Abstract: With applied biometrics, it is possible to identify a person by examining a feature vector of attributes derived from their physical and behaviour characteristics. In biometrics, fingerprints have become one of the most famous and well known techniques of identification and authentication. In light of technological advancements and safety, fingerprint recognition has been successfully used in a variety of Civil, Defence, and Commercial applications for more than a decade. The …
Published in International Journal of Wireless Security and Networks · Vol. 1, Issue 2, 2023 · pp. 1–12 Read article
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
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FRW Universe in R2 Gravity
Abstract: We investigate a model of the Friedmann Robertson Walker metric (FRW) universe governed by hybrid expansion law (HEL) a = tα eβt in R2 gravity. By Applying, energy and stability conditions in derived model, we check its physical viability. This model is based on f (R, T) = f (R) + f (T); f (R) = R + αR2 and f (T) = T and we have assumed T = …
Published in Journal of Polymer & Composites · Vol. 11, Issue 7, 2023 · pp. 75–80 Read article
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Bioethanol and Beyond: A Comprehensive Review on Sustainable Biofuels for Global Energy Demands and Environmental Conservation
Abstract: This comprehensive review explores the concept of "biofuels," specifically focusing on energy-enriched chemicals generated through biological processes or derived from the biomass of living organisms, including microalgae, plants, and bacteria. As the global population continues to increase, there is a growing demand for more energy supplies to enhance the quality of life. Biofuels, harnessed from various sources such as sugar, starch, and organic waste, have emerged as potential solutions to …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 1–9 Read article
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Perturb and Observe Maximum Power Point Tracking Technique with PID Controller for a Wind Power System
Abstract: The wind power generation system has a significant growth worldwide over the past four decades. The wind power generation system has strong coupling and linear characteristics which makes it a complicated electromechanical system. The power control strategy has a higher impact on the overall performance as the wind power generation is operated at variable and random wind speed conditions. PID control is the most used control algorithm in industrial applications. …
Published in International Journal of Advanced Control and System Engineering · Vol. 1, Issue 1, 2023 · pp. 15–25 Read article
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Neural Network Based Fractional Order PID Controller for Harmonic Mitigation of Induction Motor Drive System
Abstract: Torque produced in IM (induction Motor) is collected fundamental torque, however, due to core saturation, air gap irregularity, and winding distribution; stator and rotor slotting harmonics torque are produced. This reduces the quality of the power system, life span, and performance of the motor and the controller device. In this paper, a neural network, based fractional order proportional integral derivative (NNFOPID) controller is designed to compensate the harmonics of the …
Published in International Journal of Electrical Power and Machine Systems · Vol. 1, Issue 1, 2023 · pp. 23–41 Read article
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Comprehensive Review on Brake Friction Materials
Abstract: Automobile manufacturers are currently dedicated to enhancing vehicle speeds for the purpose of saving travel time. However, achieving this objective necessitates the use of friction materials capable of handling high-speed braking. In this article, we will delve into the historical evolution of materials utilized for brake pads and drums. In the past, asbestos stood out as the most widely employed brake lining material due to its effectiveness. Unfortunately, its carcinogenic …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 197–214 Read article
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Comparative Study Between Dashavatara (Incarnation) and Darwinian Theory of Evolution
Abstract: The word Dashavatara derives from Dasha, meaning “Ten”, and Avatara, roughly equivalent to “Incarnation”. Lord Vishnu manifested in various avatars to safeguard the universe and reinstate “peace and dharma” during the four distinct yugas, or cosmic cycles. The Hindu text Dashavatara, which describes ten forms of Lord Vishnu, has a better developed theory of evolution than the hypothesis put out by English scientist Charles Darwin in the 17th century. Objective …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 14, Issue 1, 2024 · pp. 50–58 Read article
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Influence of Aspect Ratio on the Mechanical and Tribological Properties of Vertical Centrifugal Cast Aluminium Silicon Alloy
Abstract: To get a sound cast of precise shape and size in the vertical centrifugal casting process, the flow behavior of the melt and process parameters such as aspect ratio of the mould, rotating speed, volume fraction, etc. must be optimized. The optimal parameters of the vertical centrifugal casting process derived from past cold modelling studies in casting of Al-12%Si alloy are investigated in this paper. Casts were obtained using 7 …
Published in Journal of Polymer & Composites · Vol. 11, Issue 13, 2023 · pp. 104–111 Read article
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The Use of Autologous Platelet-Rich Plasma in Treating Web Space Scar Contractures in Pediatric Burn Patients
Abstract: Burn injuries are prevalent among children, with scald injuries emerging as the predominant type among those under the age of five, constituting more than 65% of cases. Despite receiving appropriate initial treatment and compressive therapy, deep burns often result in contractures, with web space and hand contractures being the most frequent and functionally limiting.To address these challenges in burn management, Autologous Platelet Rich Plasma (APRP) has emerged as a significant …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 1–5 Read article
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Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
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Assessment of Diuretic Activity of Hydroalcoholic Extract of Matricaria Chamomilla (Linn.) and Its Phytochemical Analysis with Emphasis on Toxicology
Abstract: While the traditional medicines are derived from medicinal plants, minerals and organic matter, the herbal drugs are prepared from medicinal plants only. This current research work will be very beneficial in figuring out the Matricaria chamomilla leaves extract diuretic effect by determining the ions and electrolyte excreted by the animals using ion selective channel inhibition. The phytochemical screening results revealed that the after which it was observed whether the alkaloids …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 1–10 Read article