Search
675 articles for “Novel”
-
Proof-of-Minimum Privacy Leak Consensus Strategy in Blockchain
Abstract: In this study, we propose a novel consensus algorithm to preserve the security and privacy of a transaction. We propose a Proof-of-Minimum Privacy Leak consensus strategy. This means that the competing nodes which participate in the competition to mine the next block should give a proof of minimum privacy leak during its transaction. Only this proof will give highest votes to that node, and it will be elected as the …
Published in E-Commerce for Future & Trends Read article
-
Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
-
Melanogenic Inhibitory Effects of Sesamum indicum Phytocompounds Towards CDK 2, c-KIT, and BRAF.
Abstract: Objective: Melanoma is thought to be the fifth most frequent cancer in the US population, despite cancer being the most common cause of death in the globe. BRAF, CDK2, and c-KIT proteins are regarded as potential therapeutic agents since mutations in these proteins are the primary cause of melanoma. For the investigation of their pharmacological properties and therapeutic activities against the target proteins, Sesamum indicum L. and its phytocompounds were …
Published in International Journal of Bioinformatics and Computational Biology Read article
-
Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments
Abstract: Objective: Parkinson's disease, behind Alzheimer's, is the second most common neurodegenerative ailment and a major cause of neurological morbidity worldwide. Clinical diagnosis is made, and current management is limited to symptomatic treatments, with levodopa remaining the cornerstone of pharmaceutical therapy. In certain patient groups, deep brain stimulation of specific basal ganglia targets can provide significant clinical relief. There are currently no proven disease-modifying medicines in clinical use that can halt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 27–39 Read article
-
The Current State of Huntington's Disease Treatment: An Overview of Palliative Care and Symptom Management
Abstract: Huntington's disease (HD) is a neurodegenerative ailment that adversely affects the basal ganglia and the cortex of the brain. Although there is no recognized cure for HD, symptomatic relief and therapeutic management of the condition have improved over the course of time. This review paper provides an up-to-date overview of the current treatment options and symptom management strategies utilized in the care of HD patients. Additionally, it highlights the existing …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 Read article
-
Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
-
Wireless Sensor Network Localization Based on Static Anchor Node
Abstract: Anchor-based localization is a crucial challenge in wireless sensor networks (WSNs), aiming to determine the positions of all sensors by leveraging a limited number of anchor nodes whose locations are known. In this paper, we propose a novel algorithm for anchor-based localization in a static network, which improves the localization accuracy while reducing the computational complexity compared to existing methods. Our algorithm uses a range-based approach to estimate the distances …
Published in International Journal of Wireless Security and Networks · Vol. 1, Issue 1, 2023 · pp. 12–20 Read article
-
Application of Grey Wolf Optimizer (GWO) strategy for Malware Analysis
Abstract: The ever-evolving landscape of cybersecurity necessitates continuous advancements in malware analysis techniques. This study explores the deployment of the Grey Wolf Optimizer (GWO) algorithm as a novel bio-inspired optimization mechanism to address the challenges posed by modern malware threats. The primary objective is to enhance various facets of malware analysis, including feature selection, parameter optimization, and the overall efficacy of malware detection models. The study begins by introducing the GWO …
Published in International Journal of Wireless Security and Networks · Vol. 1, Issue 2, 2023 · pp. 43–53 Read article
-
Multidirectional Autonomous UV Sanitation Robot
Abstract: In the healthcare environment, the spread of infectious diseases through respiratory particles poses a significant challenge to maintaining clean and safe surroundings. With shortages in surface disinfectants, the traditional manual cleaning methods have been put under scrutiny, as they often prove inadequate and leave residual contamination. Moreover, the constant operation of healthcare facilities, coupled with staff turnover, increases the risk of virus transmission among healthcare workers. To address these concerns, …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 1, Issue 1, 2023 · pp. 1–10 Read article
-
Design and Simulation of Low-power, High-speed Effective Area Mux Based One-bit Full Adder Using CMOS Technology
Abstract: Our findings reveal a novel kind of circuit capable of performing both XOR and XNOR operations in parallel. Power dissipation and delay are both greatly reduced in the proposed circuits due to their low output capacitance as well as minimal short-circuit power dissipation. We show six new hybrid 1-bit full-adder (FA) circuits that take use of the XOR-XNOR or XOR/XNOR gates' special full-swing function. Each potential circuit layout has both …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 1, Issue 1, 2023 · pp. 25–33 Read article
-
Design and Development of Ankle Foot Orthosis for Foot Amputated Person by Using Carbon Fibre
Abstract: Ankle and foot orthotics play a pivotal role in the rehabilitation of individuals who have suffered a stroke, aiding in the restoration of their gait and overall mobility. However, optimizing the effectiveness of these orthoses requires a personalized approach that takes into account each patient's unique biomechanical characteristics. This study delves into the innovative use of carbon fiber combined with cost-effective 3-D printing technology to craft custom foot plate orthoses …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 115–121 Read article
-
Detection of Pneumonia in COVID-19 Patients Using X-ray Images
Abstract: This study explores the use of chest X-ray image analysis and deep learning methods to identify pneumonia in COVID-19 patients. Due to the pandemic, Proper as well as immediate examination of COVID-19 is now essential for patient care and disease control. This study proposes a novel approach that uses convolutional neural networks (CNNs) to automatically predict pneumonia in COVID-19 patients using chest X-ray images. In this study, an X-ray of …
Published in International Journal of Radio Frequency Innovations · Vol. 1, Issue 1, 2023 · pp. 13–23 Read article
-
Automobile Collision Detection System Using GSM and GPS
Abstract: The accelerometer detects changes in the vehicle’s axis and the GSM module sends an alert message to the phone indicating the location of the event. Advanced technology makes our daily life easier. Because every coin has two sides, technology has both strengths and weaknesses. The development of technology has increased the number of traffic accidents, resulting in numerous deaths. The poor medical facilities that exist in our country exacerbate the …
Published in International Journal of Manufacturing and Production Engineering · Vol. 1, Issue 1, 2023 · pp. 15–19 Read article
-
Mitigation of Peak to Average Power Ratio in Orthogonal Frequency Division Multiplexing through SOP-PTS
Abstract: Orthogonal Frequency Division Multiplexing (OFDM) is a popular multicarrier modulation technology extensively employed in 4G wireless communication systems to transmit data over a dispersive channel. To address the Peak-to-Average Power Ratio (PAPR) issue in OFDM, a technique called Partial Transmit Sequence (PTS) is commonly utilized. The PTS method involves dividing the data block into non-overlapping sub-blocks and then combining them using phase factors to mitigate PAPR. However, the conventional PTS …
Published in International Journal of Radio Frequency Innovations · Vol. 1, Issue 1, 2023 · pp. 32–39 Read article
-
Bioactive Compounds in Ethanolic Extract of Strychnos innocua Root Using Gas Chromatography and Mass Spectrometry (GC-MS)
Abstract: Medicinal plants are of great relevance with endless pharmaceutical and therapeutic properties. They are source of wide array of secondary metabolites or bioactive compounds/phytochemicals (phenols, alkaloids, flavonoids, terpenoids, tannins, steroids and saponins) which can discharge numerous biological functions (antimicrobial, antioxidant, antiviral, antifungal, anti-fibrotic, immune-modulatory, cytotoxic, antipyretic, antitumor, antihelminthic, antiprotozoal, antibacterial, and so on). The use of gas chromatography and mass spectrometry analysis in identifying the bioactive compounds in the ethanolic …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 9–14 Read article
-
Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
-
Tinospora Sinensis Compounds for Zika Virus Targets 5JRZ and 5KVD In Silico Screening: A Potential Approach to Preventing Guillain-Barre Syndrome
Abstract: Objective: GBS is a very rare kind of disease but at the same time, it is very dangerous too. The study estimates that people who are suffering from zika virus infection are more prone to GBS. According to surveys, 1 out of 4000 people got affected by this disease, and the scariest part of this disease is that there is no cure available. In this computational era drug discovery is …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 1–15 Read article
-
QCA-based Implementation of Budget-friendly and Energy-Efficient Exclusive-OR/Exclusive-NOR Gates
Abstract: Quantum-dot cellular automata (QCA) is a novel nanoscale computational approach that proposes reduced dimensions, lower power consumption, increased speed, and deliberate design as a solution to the scaling challenge associated with CMOS technique. QCA is a nascent nanotechnology that utilizes the Coulomb repulsion principle. Quantum computing has emerged as a highly effective paradigm for the creation of energy-efficient hardware at the nanoscale. This article presents implementation of a very efficient …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 1, Issue 2, 2023 · pp. 1–6 Read article
-
Design and Development of Additive Manufacturing Machine
Abstract: Rapid prototyping, commonly referred to as 3D printing or additive manufacturing (AM), is the process of creating three-dimensional objects by layer-by-layer addition of material. It is very different from subtractive and conventional forming techniques. The goal of this special issue is to gather research and advancements in additive manufacturing (AM), with an emphasis on novel manufacturing techniques and substitute products and materials for feedstock. Although metal and polymer-based materials have …
Published in International Journal of Electrical Power and Machine Systems · Vol. 1, Issue 1, 2023 · pp. 1–7 Read article
-
Clinical Profile of Dengue Patients who had a Prior Infection with the Covid 19 Virus in a Tertiary Care Centre
Abstract: This cross-sectional analytical study conducted in a tertiary care center aims to investigate the clinical profile of Dengue virus-infected patients with a prior history of COVID-19 within the last three years. Dengue, a prevalent tropical disease, ranges from mild fever to severe conditions like hemorrhagic fever and shock syndrome. The study utilizes the World Health Organization's 2009 classification for Dengue and delineates the febrile, critical, and recovery phases of infection. …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 34–38 Read article