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175 articles for “Lead compound.”
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Molecular Docking Studies for the Identification of Mycobacterial Adenosine Triphosphate (ATP) Synthase Inhibitors Using Active Phytocompounds from Plants Curcuma longa, Curcuma zedoaria and Galipea officinalis
Abstract: Objective: Tuberculosis (TB), known in human history for several decades, remains the second leading infectious disease after COVID-19. Still, the occurrence of TB increases due to the bacterium’s greater survival nature. They can survive in extreme conditions by being in long latency and adapting to the host. This study seeks to identify potential inhibitors from Curcuma longa, Curcuma zeodaria, and Galipea officinalis based on ancient folklore and compare them against …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 16–26 Read article
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Design and Experimental Analysis of Steel Fibre Reinforced Concrete
Abstract: The concrete structure when exposed to elevated temperatures, shows the various compound changes in the substantial which prompts weakening of the construction. The principle objective of the review is to diminish the underlying component disappointment when presented to raised temperature, which thusly builds the departure time of the inhabitants during fire mishaps. Further, when the structures are presented to fire, there is the opportunities for the opposite finish of the …
Published in Recent Trends in Civil Engineering & Technology · Vol. 12, Issue 1, 2022 · pp. 11–20 Read article
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Unlocking The Bioactivity Potential: Molecular Insights and Predictions of Salen, Salophen, Allicin, Curcumin, and Piperine
Abstract: In this work, the prediction of the biological activity of several significant molecules, including salen, salophen, allicin, curcumin, and piperine, are discussed. Using Molinspiration software, the molecular properties of these compounds were calculated. These molecules are highly significant due to their extensive potential in medical applications. Salen and salophen, for instance, play crucial roles in cancer chemotherapy and act as inhibitors of angiogenesis. Curcumin is renowned for its antioxidant properties, …
Published in International Journal of Cheminformatics · Vol. 1, Issue 2, 2023 · pp. 14–21 Read article
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Turmeric as a Key Ingredient in Cosmeceuticals: New Scientific Evidence
Abstract: Turmeric (Curcuma longa), particularly its active compound curcumin, is gaining recognition in cosmetics and medicine for its therapeutic properties. Its antioxidant, anti-inflammatory, and antimicrobial effects make it a popular skincare ingredient, helping reduce inflammation, brighten skin, and fight aging. In addition to treating dandruff and promoting hair growth, Turmeric is also good for scalp health. Curcumin increases the body's antioxidant defenses. Inhibits inflammation and anti-oxidants. Curcumin, a powerful compound found …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 1, 2025 · pp. 28–36 Read article
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Al-Razi’s Anatomical Insights: A Detailed Review of Kitab Al-Mansuri
Abstract: Al-Razi (865–925 CE), a leading physician of the Greco-Arab Golden Age, made foundational contributions to human anatomy through clinical observation and empirical analysis. This review explores Al-Razi's anatomical insights, particularly as recorded in his influential medical compendium Kitab al-Mansuri (The Book of Medicine Dedicated to al-Mansur). In this work, Al-Razi challenges the prevailing Galenic doctrines by prioritizing evidence-based understanding over uncritical acceptance of ancient texts. His method reflects a scientific …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 3, 2025 · pp. 1–7 Read article
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Phyto-bioefficiency of Vijaya Extract for Normal Cell Protection and Its Anticancer Efficiency Against Breast Cancer Xenograft
Abstract: Cannabis is an annual, dioecious, flowering herb. Its leaves are palmately compound by serrate leaflets. Cannabis sativa maximum phytochemicals are soluble in organic solvent. The Cannabis plant has been historically used due to its medicinal properties since thousands of years through several beliefs. In India, the department of narcotics has sanction that Cannabis can be grown in a monitored way with proper approval and license. The present study concludes that …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 3, 2022 · pp. 15–21 Read article
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Integrated Approach of Unani Medicine in Geriatric Care
Abstract: Aging is a process of physical, psychological and social changes in multidimensional aspects. The percentage of elderly, in the world population is expected to increase rapidly from 9.5% in 1995 to 20.7% in 2050 and 30.5% in 2150. In India, the population of older people has risen from 4.9% in 1901 to 5.5% in 1951, 6.5% in 1991, 7.7% in 2001, and 8.3% in 2011 and will be 12% in …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 2, Issue 1, 2015 · pp. 4–9 Read article
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Evaluation Of Anti Obesity Activity Of Citrus Sinensis & Citrus Limon By High Fat Diet Induced Model Using Danio Rerio
Abstract: Obesity, defined by the World Health Organization (WHO) as an abnormal or excessive fat accumulation that may impair health, is becoming one of the greatest challenges to global health in this millennium, with more than 300 million men and nearly 450 million women obese globally in 2018. Obesity turns into serious problem globally. Zebrafish model can be used extensively for drug screening due to its low maintenance cost, comparatively short …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 24–31 Read article
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A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article
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IN SILICO EVALUATION OF INHIBITORY POTENTIAL OF SOME COMMERCIALLY AVAILABLE FLAVONOIDS AGAINST BETA- SECRETASE IN THE MANAGEMENT OF ALZHIEMER’S DISEASE
Abstract: In a continuing effort to develop multitargeted compounds as potential treatment agents against Alzheimer's disease (AD), a certain commercially available flavonoids were evaluated against crystal structure of beta-secretase enzyme using in silico docking studies. In this perspective, flavonoids like apigenin, galangin, gallocatechol, genistein, luteolin, myricetin, and theaflavin were selected. AutoDock 4.2 software was used for the in-silico docking studies which possess the principle of Lamarckian genetic algorithm. In the docking …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 30–35 Read article
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A New Developed Hydrogen Generator for Hydrogen Electric Vehicle
Abstract: Hydrogen practically does not occur in its pure form on Earth and must be extracted from other compounds using various chemical methods. There are currently many methods of industrial hydrogen production, which include: steam reforming of methane and natural gas; coal gasification; biotechnology; water electrolysis. Hydrogen production by water electrolysis has a number of advantages over other methods, including: availability of available raw materials (water); a wide range of hourly …
Published in Recent Trends in Fluid Mechanics · Vol. 10, Issue 1, 2023 · pp. 1–13 Read article
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Unani Medicinal Plants with Anti-HIV Potential
Abstract: Acquired immune deficiency syndrome (AIDS) is a result of human immunodeficiency virus (HIV) infection which subsequently leads to severe suppression of immune functions. AIDS is a significant threat to the health of mankind as there is no curative treatment for HIV infection and AIDS. Current anti-retroviral therapies (ART) are quite expensive or unaffordable by common man and are associated with adverse effects and rapid emergence of drug resistance. Therefore, the …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 1, Issue 2, 2014 · pp. 11–22 Read article
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A Brief Review on Perovskite Materials: Synthesis, Properties, and Applications
Abstract: Perovskite materials have emerged as a transformative class of compounds, capturing widespread interest due to their remarkable properties and diverse applications across various fields, including optoelectronics, catalysis, energy storage, and environmental technologies. The synthesis techniques, classification, and unique properties of perovskite materials are thoroughly examined in this paper, which highlights the materials' potential to completely transform a number of sectors. One of the standout features of perovskites is their highly …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 1, 2025 · pp. 42–49 Read article
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Understanding the Role of Remote Sensing Techniques in Monitoring Air Quality for Effective Adherence to Environmental Impact Assessment Practices in Nigeria
Abstract: The paper reviews the Nigerian Environmental Impact Assessment (EIA) Act, outlining the established air quality thresholds and emission caps for stationary sources. The standard applies to; common pollutants like sulphur dioxide, carbon monoxide, ozone, particulate matter and nitrogen oxides; toxic metals such as arsenic, nickel, cadmium and mercury; as well as volatile organic compounds, ammonia, antimony, zinc, formaldehyde and radon.It also describes the major classifications of remote sensing applications, including …
Published in International Journal of Satellite Remote Sensing · Vol. 4, Issue 2, 2026 Read article
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Regression Analysis of Topological Indices and Physicochemical Properties of Polymer-Based Anticancer Drugs
Abstract: The research analyzed the quantitative correlation between topological indices and the physicochemical properties of selected anticancer compounds using regression analysis. Various topological descriptors—such as the First Zagreb Index, Second Zagreb Index, and Forgotten Index were calculated and regressed against key molecular features, including polar surface area, melting point, and molar refractivity. The regression analysis revealed linear correlations between these topological indices and the properties of anticancer drugs, with particularly strong …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 255–267 Read article