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208 articles for “target identification”
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Understanding of Environmental and Cultural Factors Affecting Online Purchase Behavior
Abstract: Online purchase behavior is influenced by a complex interplay of environmental and cultural factors, which are critical to understanding the context of e-commerce. This research aims to explore how these factors shape consumer behavior, providing insights for businesses to enhance their online strategies. Environmental factors include technological infrastructure, economic conditions, and regulatory policies that create the backdrop against which online transactions occur. For instance, a robust internet infrastructure and favorable …
Published in Journal of Communication Engineering & Systems · Vol. 14, Issue 3, 2024 · pp. 29–36 Read article
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Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article
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Gold Nanoparticle Size, Biodistribution, and Toxicity: Insights from DualEnergy CT
Abstract: Dual-energy and spectral computed tomography (CT) have emerged as powerful platforms for noninvasive, quantitative mapping of nanoparticle biodistribution in vivo. By exploiting the energy-dependent attenuation profiles of high-atomic-number (high-Z) materials, these systems enable material decomposition and element-specific imaging, thereby distinguishing nanoparticle signals from those of soft tissues and conventional iodinated contrast agents. Photon-counting spectral CT further enhances this capability by binning individual photons into multiple energy channels, improving spatial resolution, …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article
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Malicious Application Detection in Windows Using SVM Algorithm
Abstract: In recent years, both the development of Windows application clients and the uses of smart mobile phones have increased significantly. As the number of Windows application users continues to grow, there is a rise in malicious individuals who develop harmful Windows applications with the intent of unlawfully obtaining confidential information and engaging in fraudulent activities. These applications are designed to target vulnerable areas such as mobile banking and digital wallets, …
Published in International Journal of Mobile Computing Technology · Vol. 1, Issue 1, 2023 · pp. 30–36 Read article
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Evaluation of Emergency Response Plans in Industrial Environments Using Simulation Techniques
Abstract: Industrial facilities, particularly those in the chemical, manufacturing, and energy sectors, face significant hazards due to their complex operations and the handling of hazardous materials. Ensuring the safety of workers and minimizing the impact of incidents require robust and effective emergency response plans (ERPs). Traditional evaluation methods, such as drills and tabletop exercises, often fall short in replicating the complexities of real-world emergencies. These methods may lack the realism needed …
Published in Journal of Industrial Safety Engineering · Vol. 11, Issue 3, 2024 · pp. 6–10 Read article
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Clinical Evaluation of Ayurvedic Intervention (Mahamanjishathadi Kwatha, Kaishora Guggulu, Panchatikta Ghrita, Eranda Taila) in the Management of Ekakushtha W.S.R. to Psoriasis
Abstract: Introduction: Psoriasis is a chronic skin condition causing scaly plaques, typically on extensor surfaces, scalp, and nails, and often leads to quality of life impairments, including physical and mental health challenges. Ayurveda offers a holistic approach targeting root causes and balancing body and mind, while conventional treatments focus on symptom management through therapies that may cause side effects and recurrence. Aim and Objectives: The study aimed to assess the efficacy …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 1, 2025 Read article
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
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Towards smart cancer care - AI enhanced monitoring and intervention
Abstract: According to estimates from the World Health Organization (WHO) for 2022, cancer is one of the leading causes of mortality, accounting for roughly 16% of all deaths globally. The goal of the cancer community is to improve the lives of those who are impacted by cancer and to cut the cancer death rate in half during the next several years. If cancer is identified early and treated, its impact on …
Published in Journal of Microwave Engineering and Technologies · Vol. 12, Issue 1, 2025 · pp. 38–44 Read article
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Unveiling the Relationship Between Anxiety and Self-Esteem in Adult Populations
Abstract: The purpose of this study was to investigate the intricate connection between anxiety and self-esteem in adult Delhi National Capital Region (NCR) residents. A purposive sample approach was employed to select seventy people from this region. The study measured participants' self-worth and gathered pertinent background data using the Rosenberg Self-Esteem Scale (RSES) and a sociodemographic data form. In the data analysis, a t-test was employed to assess significant differences between …
Published in International Journal of Children · Vol. 2, Issue 2, 2025 · pp. 35–44 Read article
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Challenges And Constraints Affecting Female-Owned Rural Farm Businesses in Plateau State, Nigeria
Abstract: This study examined the challenges and constraints affecting female-owned rural farm businesses in Plateau State, Nigeria. No prior study had conducted a comprehensive, quantitative, state-wide investigation covering all 17 local government areas (LGAs) of the state, and this study addressed that gap. The objectives were to identify the challenges faced by female-owned rural farm businesses, assess their relationship with business performance, and determine how strongly these challenges predicted performance outcomes. …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 1–13 Read article
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Computer Aided Drug Designing for Targeted Drug Delivery Systems
Abstract: The discovery and development of a contemporary sedate is widely acknowledged as an extremely difficult task that requires significant resources and effort. Therefore, computer-aided medication design techniques are widely utilized today to increase the productivity of the drug discovery and development process. Among structure-based and ligand-based drug design approaches, both recognized for their efficiency in drug discovery and development, various CADD (Computer-Aided Drug Design) techniques are evaluated based on specific …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 34–41 Read article
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Deciphering Th-Related Gene Interactions in Chronic Spontaneous Urticaria: Bioinformatics Insights and Drug Affinity Exploration
Abstract: Objective: There has been a great deal of interest in how inflammatory dermatosis and The cell interact, but the etiopathogenesis of chronic spontaneous urticaria (CSU) is still inadequately comprehended. Through bioinformatics techniques, the purpose of this work is to elucdate the molecular mechanism underlying Th-related genes in CSU and seeks to find the highest affinity drug. Methods: The CSU RNA expression profiling dataset provided the basis for the investigation. The …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 1–15 Read article
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Non -Invasive Ways to Detect Cancer
Abstract: Cancer is a diverse group of diseases characterized by uncontrolled cell growth and division, affecting millions worldwide and being a leading cause of death. The disease typically involves genetic alterations that disrupt the normal balance of cell growth, leading to the formation of tumors. Tumors can be benign, posing no threat as they do not spread, or malignant, capable of invading nearby tissues and metastasizing. There are more than 100 …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 59–67 Read article
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Historical Antecedents of Boko Haram Insurgency and Its Implications on Educational Development in Northeast Nigeria
Abstract: The Boko Haram insurgency has greatly affected the socio-economic and educational systems of Northeast Nigeria. This paper examines the historical antecedents of the insurgency, analyzing how socio-political, economic, and ideological factors have contributed to its emergence and persistence. The study highlights the enduring impact of colonial legacies, socio-economic marginalization, and governance failures, which have collectively created fertile ground for the radicalization of disenfranchised populations. The insurgency’s deliberate targeting of educational …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 14, Issue 3, 2024 · pp. 54–63 Read article
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The Issues for Introducing Green Hydro-electricity and Electric Vehicles in Transport: Energy Sector of South Asian Region
Abstract: The rapidly developing South Asian region has immense potential of amassing huge personal car population in upcoming years requiring supply of vast amount of fossil fuel whereas this region has no sizable fossil fuel reserve. This paper investigates the potential of hydro-electricity generation from Nepal and Bhutan areas of the region, electric vehicle introduction in increasing proportion for changing the course of unsustainable transport-energy trend in this region and achieving …
Published in Trends in Transport Engineering and Applications · Vol. 11, Issue 3, 2024 · pp. 1–13 Read article
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Stilbenes: A Molecular Docking and ADMET Analysis Approach on an Emerging Resource for Scavenging Reactive Oxygen Species in the Field of Colon Malignancy
Abstract: Objective: Colon malignancy, also referred to as colon cancer, originates as precancerous polyps in the colon or rectum, which have the potential to thrive and progress into cancerous tumors over time. This study delves into various bioactive compounds (from natural sources like plants) to assess their potential efficacy in inhibiting colon malignancy as compared to conventional methods. Methods: The objective of this study was to employ computational methodologies to evaluate …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 29–38 Read article
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Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Physiotherapeutic Strategies to Enhance Throwing Accuracy in Cricket Players
Abstract: Background: Throwing accuracy is a crucial skill for cricket players, impacting both individual performance and team success. Physiotherapeutic strategies can enhance throwing mechanics, strength, and flexibility, leading to improved accuracy. Objectives: This study aims to outline effective physiotherapeutic interventions that optimize throwing accuracy in cricket players. Methods: A comprehensive review of current literature and practices was conducted with 3 articles found through PubMed, Google Scholar & Research Gate year range …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 30–34 Read article
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The Evolution of Bio Crypt Keys: From Concept to Implementation
Abstract: With the rapid increase in data exfiltration due to cyber-attacks, Covert Timing Channels (CTCs) have emerged as a significant and sophisticated network security threat. These channels exploit inter-arrival times of data packets to exfiltrate sensitive information from targeted networks. Detecting CTCs increasingly relies on machine learning techniques, which use statistical metrics to differentiate between malicious (covert) and legitimate (overt) traffic flows. However, as cyber-attacks become more adept at evading detection …
Published in Journal of Control & Instrumentation · Vol. 15, Issue 2, 2024 · pp. 38–45 Read article