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217 articles for “pathogen”
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A Community-Based Study to Assess: The Aggravating Factors and Treatment Choices in Youth with Acne
Abstract: Background and Aim: Acne vulgaris is a common dermatological condition affecting youth worldwide. While its pathogenesis is well-understood, individual experiences with aggravating factors and treatment choices vary. This study aimed to evaluate self-reported factors aggravating acne and determine treatment choices among youth with acne while assessing the correlation between self-perceived and clinically assessed acne severity. Methodology: A cross-sectional survey was conducted with 390 participants aged 18–24 suffering from acne. Data …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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Development of a Novel Therapeutic Approach Using RNA Interference for Targeting Viral Genes
Abstract: RNA interference (RNAi) is a ground breaking therapeutic strategy that holds immense promise for targeting viral genes in the treatment of viral infections. This approach leverages the natural gene-silencing mechanisms of RNAi to inhibit viral replication and expression at the molecular level, providing a precise and adaptable method to counteract viral pathogens, including influenza, HIV, and hepatitis viruses. Recent advancements in RNAi technology have enabled the development of highly specific …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 12–22 Read article
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Review of Current Trends in Vaccine Development against Zoonotic Viruses: Challenges and Innovations
Abstract: The emergence of zoonotic viruses poses a significant threat to global public health, necessitating rapid advancements in vaccine development. This review highlights the current trends and innovative strategies employed in the creation of vaccines against zoonotic pathogens, including but not limited to viruses responsible for diseases such as Ebola, Zika, Nipah, and more recently, SARS-CoV-2. We discuss various vaccine platforms, including inactivated, live attenuated, mRNA, and viral vector vaccines, focusing …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 1–11 Read article
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Non-Enzymatic Glycation in Alzheimer’s and Parkinson’s Disease: A Molecular Approach to Pathology and Recent Advances
Abstract: Non-enzymatic glycation, a biochemical process by which reducing sugars spontaneously bind to proteins, leads to the formation of advanced glycation end-products (AGEs), which have emerged as critical contributors to the pathogenesis of several neurodegenerative diseases, particularly Alzheimer’s disease (AD) and Parkinson’s disease (PD). The accumulation of AGEs can significantly alter protein structure, stability, and function, triggering a cascade of detrimental effects, including increased oxidative stress, heightened neuroinflammation, and the promotion …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 36–41 Read article
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Molecular Docking of Nigella Sativa Phytocompound as Inhibitors of Transcription Factors NF-KB Implicated in Rheumatoid Arthritis
Abstract: Objectives: Nigella sativa, a plant considered around the world as the most treasured nutrient-rich herb for centuries together in different civilizations, is exceptionally known for its high levels of antioxidant properties. Free radical intensification due to oxidative stress plays a key role in the pathogenesis of rheumatoid arthritis by activating the NF-KB protein that regulates the expression of the genes involved in inflammation. Methods: This study involves in-silico approach to …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 42–55 Read article
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Drug Resistance – Challenges & Ayurveda Solutions – Review Study
Abstract: Antimicrobial resistance & anticancer medicine resistance has been the challenge to the medical fraternity. There are different theories postulated for developing medicine resistance, that has resulted in the debate regarding the efficacy of the medicine; there has been increasing concern as the time take for developing resistance is getting shorter and the time for development a molecule has remained constant or increasing. This resulted in medicinal resistance within few years …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 13–16 Read article
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FMR1 Key Biomarker in Fragile X Syndrome- A Comprehensive Review
Abstract: Fragile X Syndrome (FXS) is a complicated neurodevelopmental condition that causes intellectual disabilities, behavioural issues, and a variety of physical symptoms. Central to understanding FXS is the Fragile X Mental Retardation 1 (FMR1) gene, pivotal in the disorder's pathogenesis. This review examines FMR1 as a key biomarker in FXS, drawing on recent research insights. The FMR1 gene, situated on the X chromosome, encodes the fragile X mental retardation protein (FMRP), …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 8–18 Read article
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Harnessing Ethylene and Brassinosteroids for Enhanced Agricultural Productivity and Food Quality
Abstract: This study provides a comprehensive review of the roles of ethylene and brassinosteroids, two vital hormonal regulators in plants, focusing on their impact on fruit ripening, stress responses, and overall plant growth. Ethylene, a gaseous plant hormone, is recognized as a key regulator in various physiological processes, particularly in the maturation of fruits. Its involvement in the ripening process has profound implications for agricultural practices, as it directly influences the …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 2, 2024 · pp. 29–32 Read article
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In-Silico Studies of Phytochemicals from Allium sativum with H5N1 Protein in Avian Influenza
Abstract: Allium sativum or garlic is a medicinal plant that is reported for its applications in many biological activities, such as its antiviral, antidiabetic, and anti-inflammatory properties, etc. In this paper, the focus has been the identification of potential phytochemicals that can be extracted from Allium sativum that can act as a candidate for drug formation that possesses the capability to inhibit the H5N1 Avian Influenza, a type of highly pathogenic …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 50–60 Read article
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Efficacy Evaluation of Trichoderma Harzianum, T. Viride, & T. Asperellum: Eco-Biocontrol Agents Against Dry Rot of Potato in Pakistan
Abstract: Fusarium sambucinum is one of the most aggressive fusarium species initiating potato dry rot disease around the world and causing significant economic losses. To alleviate reliance on synthetic fungicides as their long-term use may lead to fungal resistance, biocontrol assays against threatening fungal diseases hold significant importance as an eco-friendly management approach. Antagonists are gradually becoming hotspots and hold broad applicable prospects. Trichoderma harzianum, T. viride, and T. asperellumwere screened …
Published in International Journal of Fungi · Vol. 2, Issue 1, 2025 · pp. 46–50 Read article
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Holistic Concept & Management of Male Sexual Disorders in Integrative Unani Medicine
Abstract: Sexual medicine or sexology is a multidimensional field that encompasses a wide variety of sexual dysfunctions and their management by counseling, sex therapy, and drugs. It is very difficult to know the actual prevalence of sexual problems in India. It is estimated that 5 –15% of persons of reproductive age group suffer from sexual disorders or have unsatisfactory sexual relationships. The most common sexual disorders include erectile dysfunction, ejaculatory disorders, …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2025 · pp. 18–24 Read article
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Effect of Snehpana (Lipid Based Drug Delivery System) with Shatpala Ghrit in Non-Alcholic Fatty Liver Diseases
Abstract: Among all the Drug Delivery Systems, Snehpana (~Lipid Based Drug Delivery System) is being widely used because this facilitates uniform distribution and absorption of fat and water-soluble chemical constituents. Due to their effective size-dependent properties and challenges related to the solubility and bioavailability of water-soluble drugs, this system holds a significant advantage. Numerous studies have highlighted the potential of lipid-based formulations in managing chronic and life-threatening diseases. Shatpala ghrit (SG) …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 1, 2025 · pp. 1–11 Read article
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A Comprehensive Review of Antioxidant Activity of Bhringraj (Eclipta alba) : An Indian Ancient Herb
Abstract: Eclipta alba, commonly known as Bhringraj, is an herb widely utilized in traditional Indian medicine (Ayurveda) for its diverse therapeutic properties, particularly in promoting hair growth, enhancing liver function, and improving overall health. Among its numerous biological activities, the plant’s antioxidant potential has garnered significant interest in modern phytochemistry. Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses, is a key contributor to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 1, 2025 · pp. 12–21 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Inventory of Healthcare Waste Generated at Kambia Government Hospital, Sierra Leone
Abstract: This research studies the categories and management practices of healthcare waste generated at Kambia Government Hospital and stresses the need for effective waste management to protect health and the environment. The waste is categorized into seven types: general, infectious, pathogenic, pharmaceutical, sharps, chemical, and liquid. Weekly assessments discovered fluctuations in waste generation, with general and infectious waste consistently comprising significant portions. Notably, sharps waste underscored the risks associated with injury …
Published in International Journal of Pollution: Prevention & Control · Vol. 3, Issue 1, 2025 · pp. 20–28 Read article
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Risk Factors Associated with Subclinical Mastitis in Dairy Cows: Implications for Microbial Dynamics, Environmental Influences, and Management Factors
Abstract: Subclinical mastitis is a prevalent yet often overlooked condition in dairy cows, leading to reduced milk yield and quality. This study examines the microbial dynamics, environmental influences, and management factors contributing to subclinical mastitis in dairy herds. Microbial agents, including bacteria such as Staphylococcus aureus, Escherichia coli, and Streptococcus uberis, are key contributors, with their ability to persist and form biofilms complicating detection and treatment. Environmental factors, including bedding quality, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 45–61 Read article
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Excoecaria agallocha Extract from Leaves Encounters Antifungal, Antibacterial, and Cytotoxic Activity – In Vitro Studies
Abstract: Mangroves contain a wide range of bioactive substances, certain of and these have been used as solutions for a variation of conditions for thousands of years. Excoecaria agallocha leaf application components have been extracted in the presence of organic solvents along with water-based with a Soxhlet apparatus and antibacterial research properties employing diffusion agar well assays towards nine different kinds of culture infectious agents, six clinical trials isolated compounds, as …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 1–7 Read article
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Common Diseases of Silkworm and Their Management – A Comprehensive Overview
Abstract: Silkworms (Bombyxmori L.), pivotal to the sericulture industry, are susceptible to various diseases that significantly impact cocoon production and quality. Common silkworm diseases include viral, bacterial, fungal, and protozoan infections. Prominent viral diseases, such as nuclear polyhedrosis (NPV) and cytoplasmic polyhedrosis (CPV) often cause mass mortality in larvae. Bacterial diseases, like flacherie, are typically induced by poor hygiene and environmental stress. Fungal infections, including muscardine caused by Beauveria bassiana, proliferate …
Published in International Journal of Insects · Vol. 2, Issue 1, 2025 · pp. 22–28 Read article
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Study on Chemical Insights into Alzheimer's Disease: Amyloid Beta and Tau Protein Interactions
Abstract: Background: Alzheimers disease (AD) is the most prevalent form of dementia, affecting millions of individuals worldwide and posing significant challenges to healthcare systems. The disease is characterized by a gradual decline in cognitive functions, particularly memory, reasoning, and the ability to perform daily activities. Aim & objective: To study chemical insights in alzheimers disease, especially amyloid beta and tau protein interactions Results & discussion: The results of this review highlight …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 37–46 Read article
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Nanotechnology: Effective Pesticide Solutions for Jawar Leaf Diseases
Abstract: Jawar (Sorghum), a staple food crop in many parts of the world, faces significant challenges from various leaf diseases that can drastically reduce yields and impact food security. Traditional pesticide application, while offering some protection, often suffers from limitations such as low efficiency, environmental concerns, and the development of pesticide resistance in pathogens. The application of nanotechnology is a viable option, presenting novel strategies to solve these challenges and revolutionising …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 2, 2025 Read article