Search
216 articles for “Insulin/IGF1-AKT-mTOR”
Nothing matched all of your words, so these match any of them.
-
Polycystic Ovary syndrome: A disorder of alarming proportion
Abstract: Polycystic Ovary Syndrome is one of the most important endocrine disorders that affects women of the reproductive age and may cause serious complications. Insulin resistance plays a key role in the pathophysiology of this syndrome, and this makes the use of oral anti-diabetic drugs most compelling. The majority of studies have shown amelioration of typical symptoms such as hyperandrogenism and cycle irregularities following the use of oral anti-diabetics, and ovulation …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 2, 2020 · pp. 23–27 Read article
-
Comparative study of Polyherbal anti-diabetic syrup with the Marketed formulation
Abstract: Diabetes, is commonly referred to as diabetes mellitus, it’s a group of metabolic disorder in which the person has high blood glucose (blood sugar), either due to insufficient insulin secretion or the body cells not responding to insulin. Polyuria (frequent urination) and polydipsia (growing thirst and hunger) are common in patients with high blood sugar (polyphagia). This present study reveals that comparative study of poly herbal anti-diabetic syrup with marketed …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 2, 2022 · pp. 28–32 Read article
-
Antidiabetic Activity of Triazole Derivatives: A Review
Abstract: Triazoles are the most commonly synthesized nitrogen containing hetero cyclic compounds which have a numerous biological activity viz. antifungal, antimicrobial, anthelmintic, anticancer, anti-tubercular and antiviral activities. They are 5-membered hetero ring structure containing nitrogen as heteroatom at 3 positions. Over a decade, studies are being focused on the anti-diabetic activity of 1,2,3-triazole and 1,2,4-triazole derivatives. Diabetes mellitus is a disorder in which the body doesn't produce enough insulin or does …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 1–20 Read article
-
Interplay of Thyroid Dynamics in Type 2 Diabetes: A Comprehensive Analytical Study at Government Medical College, Kota, and Affiliated Hospitals
Abstract: Diabetes mellitus is a prevalent endocrine metabolic condition that causes significant morbidity and mortality globally. Innumerable metabolic processes within our bodies depend on thyroid hormones. Excess or deficiency in insulin or thyroid hormones might cause functional problems. The intricate relationship between thyroid disorders and diabetes has been recognized for a considerable period. Patients with diabetes have been known to experience thyroid malfunction, the most prevalent kind of which is hypothyroidism. …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 1, 2024 · pp. 6–11 Read article
-
Allergic Reaction in Upper Respiratory Tract Infection (Anurjata Janya Swasa Roga) – An Ayurvedic Review and Treatment – A Case Study
Abstract: Respiratory tract infection affects the upper to lower part of the respiratory system including the nose to the alveoli of the lungs. There are two types of infections - upper respiratory infections - affecting the sinuses and throat. Upper respiratory tract infections include: common cold, epiglottitis, laryngitis, pharyngitis, and sinusitis. Lower respiratory tract infection - affects the respiratory tract and lungs. In general, lower respiratory tract infections last longer and …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 1, 2024 · pp. 26–32 Read article
-
History, Processing, Types and Health Benefits of Indian Yogurt
Abstract: Yogurt is a food which is nutrient rich and it is produced after the milk bacterial fermentation. Yogurt should have 3.25% milk fat and 8.25% milk solids non fat and the titrable acidity of at least 0.9%, which is expressed as lactic acid. Before adding bulky flavoring additives, the USDA yogurt criteria specify that the yogurt must satisfy the composition requirements of milk fat and MSNF. The data used in …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
-
Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
-
IMPACT OF DIET AND CERTAIN FUNCTIONAL FOODS IN TYPE-II DIABETES MANAGEMENT
Abstract: Global health is greatly challenged by type 2 diabetes mellitus (T2DM), whose management mostly depends on dietary and lifestyle changes. This review study looks at how important diet and certain functional items are for managing type 2 diabetes. It offers a thorough summary of current scientific discoveries and clinical investigations that emphasize the contribution of dietary decisions and functional foods to better glycemic control, increased insulin sensitivity, and decreased risk …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 1, 2024 · pp. 9–15 Read article
-
Practical approach for Type 2 Diabetes: Role of DPP4 Inhibitors
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have become essential in managing type 2 diabetes mellitus (T2DM) due to their ability to enhance incretin hormone activity, which promotes insulin secretion and inhibits glucagon release. These agents effectively lower HbA1c levels by 0.5–1.0%, are weight-neutral, and have a low risk of hypoglycemia, making them suitable for a broad patient population, including the elderly. The antidiabetic market in India is vast. Gliptin as group row …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 20–26 Read article
-
Clinical experience with Ayurvedic Treatment in Case of Rheumatoid Arthritis – Ayurvedic review and Case study
Abstract: Rheumatoid arthritis is the most found inflammatory auto immune disease with unknown etiology. Many clinical features and treatment strategies of RA are associated with multiple joint diseases. The clinical phenotype of Rhematoid arthritis is a symmetrical, deformed polyarthritis of small and large joints, which is often associated with features of the disease. The treatment typically involves ongoing management with periods of worsening symptoms followed by periods of improvement. Features of …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 2, 2024 · pp. 1–8 Read article
-
Metabolic Reprogramming in Carcinogenesis: An Overview
Abstract: Metabolic reprogramming is a crucial mechanism via which cells modify their metabolic pathways to adjust to changes in the environment and maintain growth, survival, and function. This phenomenon is of utmost importance in a wide range of physiological and pathological situations, specifically in cancer, immunological responses, and stem cell biology. In cancer, metabolic reprogramming facilitates fast cell growth and survival, as demonstrated by the Warburg effect, where cancer cells prioritize …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
-
Gut Microbiome Dysbiosis During Metabolic Disorders: Diabetes
Abstract: Understanding the intricate interplay between gut microbiome dysbiosis and diabetes is crucial due to the escalating prevalence and impact of diabetes mellitus globally. This comprehensive review examines the current understanding of this relationship, elucidating how alterations in the gut microbiome composition contribute to diabetes pathogenesis by influencing metabolic homeostasis, immune regulation, and insulin resistance. Dysregulation of gut microbial communities leads to shifts in diversity and abundance, exacerbating chronic low-grade inflammation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 56–75 Read article
-
A Web Application for Predicting Diabetes Using Machine Learning Methods
Abstract: Diabetes is a long-term disease caused by high glucose quantity in the blood. It has the potential to result in serious health complications like heart disease, hypertension, and ocular damage. It is good to identify any health issues as early as possible to get the right medical treatment and make necessary lifestyle adjustments. One makes use of machine learning techniques to predict diabetes and develop treatment options using actual cases. …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 11, Issue 3, 2024 · pp. 92–102 Read article
-
Strategy to Accelerate the Biopharmaceuticals Production Using Komogataella phaffii (Pichia pastoris)
Abstract: Revenue generation has been the primary goals for nations as well as the industries worldwide. Biopharmaceutical verticals have become potential revenue generators as they are the industrial workhorses and the economic engines that drive the upcoming biopharmaceutical industries with advances in DNA recombinant technology. A breakthrough in the indusrial biotechnology for the production of biopharmaceuticals using Pichia pastoris is awaited. Ablynx NV, Recombinant proteins (RP), HSA-pFSH beta, antibodies, borosin, N-glycoprotein, …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
-
A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women
Abstract: Polycystic ovary syndrome (PCOS) is a common hormonal condition that affects women of reproductive age. It usually begins to appear during adolescence. The ovaries produce an abnormal amount of "androgens", which are male sex hormones that are usually found in women in small quantities. Ovarian syndrome causes hormonal imbalances, irregular menstrual cycles, increased cysts in the ovaries, in addition to hair growth all over the body, acne, and pain in …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 21–28 Read article
-
Exploring the Therapeutic Potential of Phytohormones: Bridging Plant Immunity and Human Health
Abstract: This review highlights the multifaceted roles of phytohormones, including salicylic acid, abscisic acid, cytokinins, and brassinosteroids, emphasizing their contributions to plant immunity and potential therapeutic applications in human health. Phytohormones are critical regulators of plant growth, development, and defense, functioning as signaling molecules that activate and coordinate plant responses to biotic and abiotic stresses. Salicylic acid, in particular, is instrumental in systemic acquired resistance (SAR), a defense mechanism that strengthens …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 2, 2024 · pp. 20–23 Read article
-
Weaning Age Shaping Puberty in Heifer: Insights from Nutritional, Physiological, Hormonal and Environmental Perspectives
Abstract: The onset of puberty in dairy heifers is a critical determinant of their reproductive performance and overall productivity. This study reviews the influence of weaning age on the timing and quality of puberty, synthesizing insights from nutritional, physiological, hormonal, and environmental perspectives. Early or late weaning can significantly impact heifer development, influencing body weight, fat deposition, and metabolic health. Nutrition plays a vital role in shaping growth rates and reproductive …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 1, 2025 · pp. 19–31 Read article
-
Role of Carbohydrates and Herbal Plants in the Management of Diabetes Mellitus
Abstract: This extensive review explores the intricate relationship between carbohydrates and diabetes mellitus, integrating historical perspectives, biochemical foundations, and modern therapeutic approaches. The article delves into the chemistry of carbohydrates, elucidating their structural diversity and metabolic significance in relation to diabetes pathophysiology. It traces the evolution of diabetes, understanding from ancient civilizations to contemporary molecular insights, highlighting pivotal discoveries such as insulin’s identification. They critically examined various forms of diabetes, including …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 34–60 Read article
-
A Single Case Study on Ayurvedic Therapeutic Management for Increasing Growth Hormone in Pre-Pubertal Girl
Abstract: Human growth hormone, commonly referred to as HGH and somatotropin, is a naturally occurring hormone released by the pituitary gland that promotes growth in children by acting on various body regions. The pituitary gland produces the polypeptide hormone known as human growth hormone (hGH), or somatotropin, which is made up of 191 amino acids. A lack of human growth hormone (hGH) in children can result in growth failure, low stature …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 1, 2025 · pp. 19–24 Read article
-
Edible Mushrooms: Management of Diabetes Mellitus and Phytochemical Screening of Agaricus Bisporus
Abstract: A metabolic disease characterized by elevated blood glucose levels; diabetes mellitus affects millions of people. If not treated on time, it causes problems, damage organs, and even life-threatening. Studies have shown that diabetes can be avoided and controlled with a healthy lifestyle that incorporates exercise and a balanced diet. While there are several synthetic medications available to treat this illness using them over an extended period of time is linked …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 1–13 Read article