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443 articles for “design strategies”
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Cellular Mechanisms of Autophagy in Carcinogenesis: A Narrative Review
Abstract: Autophagy is a highly conserved lysosomal degradation pathway essential for cellular homeostasis, metabolic adaptation, and survival under stress. In the context of carcinogenesis, autophagy exhibits a paradoxical and stage-dependent role. During early tumor development, autophagy acts as a tumor-suppressive mechanism by limiting genomic instability, oxidative stress, and chronic inflammation. Conversely, in established malignancies, cancer cells exploit autophagy to sustain growth, survive hostile tumor microenvironments, and resist anticancer therapies. Increasing evidence …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 23–28 Read article
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Evaluation of Emergency Response Plans in Industrial Environments Using Simulation Techniques
Abstract: Industrial facilities, particularly those in the chemical, manufacturing, and energy sectors, face significant hazards due to their complex operations and the handling of hazardous materials. Ensuring the safety of workers and minimizing the impact of incidents require robust and effective emergency response plans (ERPs). Traditional evaluation methods, such as drills and tabletop exercises, often fall short in replicating the complexities of real-world emergencies. These methods may lack the realism needed …
Published in Journal of Industrial Safety Engineering · Vol. 11, Issue 3, 2024 · pp. 6–10 Read article
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Design and Simulation of LNA in 90 nm CMOS Technology for Radio Receiver using the Cadence Simulation Tool
Abstract: Due to its successful operation in the 2.4 GHz frequency region, often known as the ISM (Industrial, Scientific, and Medical) band, RFICs play a vital role in communication systems. The major parts being used transceivers for frequency translation and amplification are LNA and Mixers. Different types of mixers and LNAs are employed, and different strategies are used to optimize them. In this paper an approach for design and simulation of …
Published in International Journal of Digital Communication and Analog Signals Read article
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AI-Based Discovery of High-Performance Energy Storage Polymer Composites: A Comprehensive Review
Abstract: The accelerating global demand for high-performance energy storage systems has stimulated significant research into advanced polymer composites as next-generation electrolytes, electrode binders, and functional membranes for batteries, supercapacitors, and photovoltaic devices. However, the vast compositional and structural design space of polymer materials presents formidable challenges for conventional trial-and-error discovery strategies, which remain slow, costly, and biased by prior expert knowledge. Machine learning (ML) and artificial intelligence (AI) have emerged as …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1083–1097 Read article
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Formulation Development and Evaluation Technique for Immediate and Modified Release Capsule
Abstract: The development and evaluation of formulations for immediate-release (IR) and modified-release (MR) capsules represent a critical aspect of pharmaceutical dosage form design, offering distinct advantages in terms of drug release profiles and therapeutic outcomes. This study focuses on the formulation strategies, techniques, and evaluation methods used to develop both IR and MR capsules. Immediate-release capsules are designed to disintegrate quickly in the gastrointestinal tract, ensuring rapid drug absorption, while modified-release …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 1–9 Read article
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ANN-Based Adaptive Rotor Current Control for DFIG Wind Systems: A Comparative Dynamic Analysis
Abstract: The variability of rotor current management in Doubly Fed Induction Generator (DFIG)-based wind energy conversion systems is crucial for maintaining stability in power extraction under fluctuating wind and grid circumstances. Traditional proportional-integral (PI) controllers, despite their ease of use, frequently exhibit diminished performance when faced with parameter uncertainty, nonlinear behaviors, and rapid wind fluctuations.This paper presents an adaptive rotor current control strategy, which is an Artificial Neural Network (ANN)-based approach …
Published in Journal of Power Electronics and Power Systems · Vol. 16, Issue 1, 2026 · pp. 41–53 Read article
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Machine Learning-Based Quantification of Polymer Structure Property Relationships for Predictive Material Design
Abstract: Polymer structures exhibit complex, hierarchical arrangements that strongly influence macroscopic properties, yet consistent quantification remains challenging due to nonlinear interactions and limited unified modeling strategies. Existing approaches inadequately capture generalized structure–property mappings across diverse polymer systems. This research aims to establish a machine learning-based quantification model for polymer structure–property relationships to support predictive material design. A Polymer Structure Property Dataset of 5,000 polymer samples includes structural descriptors and experimentally measured …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 737–754 Read article
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Precision Medicine Approaches for Cancer Therapy Recent and Advance
Abstract: Recent advances in biotechnology have made it possible to identify intricate and distinctive biological characteristics linked to carcinogenesis. Proteomic and RNA studies, immunological markers, tumor and cell-free DNA profiling, and other methods are utilized to find these traits in order to optimize anticancer treatment for specific patients. In recent years, the focus of clinical trials has shifted considerably to enhance treatment outcomes in cancer therapy. Rather than being primarily centered …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 1–11 Read article
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A Study to Evaluate the Effectiveness of a Structured Teaching Program on the Knowledge and Practice of Road Traffic Accident Prevention Measures Among Teenagers
Abstract: An investigation to evaluate the impact of a structured educational program on the understanding and implementation of strategies for preventing road traffic accidents among teenagers. Introduction: Accident is an accidental injury, passing or property harm happening in a grouping of occasions. Accidents don't simply occur; they are neglectfulness, indiscretion, carelessness, and flashing absence of focus. Accidents have turned into a significant reason for dismalness and mortality, particularly among the grown-ups …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 29–40 Read article
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Computational Biomodeling: Transforming Drug Design with Advanced Simulations
Abstract: Computational biomodeling has emerged as a transformative approach in the field of drug discovery, significantly enhancing the efficiency and precision of identifying and optimizing potential drug candidates. This article explores the various computational techniques utilized in drug design, including molecular docking, molecular dynamics (MD) simulations, free energy calculations, and virtual screening, and examines how these methods collectively contribute to the drug development process. The integration of these advanced simulations allows …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 24–29 Read article
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Improving the Efficiency of Solar Cabinet Dryers: A Comprehensive Review
Abstract: Solar cabinet dryers offer an eco-friendly and sustainable solution for drying agricultural products, utilizing solar energy to reduce moisture content. However, to match the performance of conventional drying methods, there is a need to enhance the efficiency of these systems. This research article delves into various strategies to increase the efficiency of solar cabinet dryers, including design optimization, material selection, airflow management, and operational adjustments. Key improvements such as multi-pass …
Published in Journal of Refrigeration, Air conditioning, Heating and ventilation · Vol. 11, Issue 3, 2024 · pp. 22–27 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Advancing Automotive Design Through Virtual Prototyping and Finite Element Analysis
Abstract: Finite element analysis (FEA) and virtual prototyping are being incorporated, which is transforming the automotive sector. The design process is being revolutionized by emerging technologies, as this essay discusses, leading to automobiles that are more innovative safe, and efficient. With the help of virtual prototyping, engineers may construct, evolve, and optimize vehicle designs in an electronic environment, saving a lot of time and resources. This strategy is further enhanced using …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 1, Issue 1, 2023 · pp. 7–12 Read article
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Enhancing Peptic Ulcer Therapy: Innovations in Mucoadhesive Drug Delivery
Abstract: Peptic ulcer disease is still a sincere gastrointestinal demand makes medication administration difficult because of the harsh and changing stomach environment. This paper investigates the potential of using mucoadhesive drug delivery devices to improve the accuracy and effectiveness of peptic ulcer therapies. Due to the inherent characteristics of mucoadhesive drug delivery systems, localized and sustained drug release is made possible by their extended contact and adherence to the gastrointestinal tract's …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 62–76 Read article
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A Review on the Interconnection Between Drug Design and Controlled Drug Delivery Systems
Abstract: Drug discovery and delivery are two branches of science that have historically developed as independent areas of discovery – one focused on optimizing the properties of molecules for biological activity, and the other on controlling the rate, site, and duration for drug release. However, in contemporary pharmacy, these two areas have merged into a single integrated approach – where drug discovery and delivery strategies co-influence each other at each point …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 47–52 Read article
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Optimizing Data Processing Efficiency in Big Data: Advanced MapReduce Algorithm Innovations
Abstract: The exponential growth of big data in recent years has created an urgent need for innovative and efficient processing frameworks capable of managing and analyzing massive and complex datasets. Among these, MapReduce has gained prominence as a powerful tool for distributed data processing due to its simplicity and scalability. However, traditional MapReduce frameworks often encounter significant limitations in terms of efficiency, scalability, and resource optimization, particularly when handling large-scale and …
Published in International Journal of Data Structure Studies · Vol. 3, Issue 1, 2025 · pp. 1–7 Read article
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Development and Experimental Investigation of a Light Weight Hybrid Electric Vehicle Using Lithium-Ion Battery and EDLC Supercapacitor Integration
Abstract: Lightweight hybrid electric vehicles (HEVs) have gained significant attention as an environmentally friendly and efficient mode of transportation. However, their energy storage systems (ESS) often face challenges such as limited battery lifespan, inadequate power delivery during peak demand, and inefficient energy recovery during braking. This research focuses on the development and experimental evaluation of a hybrid energy storage system (HESS) integrating Lithium-Ion Batteries (LIB) and Electric Double-Layer Capacitors (EDLC) for …
Published in Journal of Automobile Engineering and Applications · Vol. 12, Issue 1, 2025 · pp. 26–40 Read article
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From Humours to Metabolism: An Integrative Review of Obesity Management in Unani Medicine
Abstract: Unani Medicine, a traditional complementary and alternative medicine (CAM) system, adopts a holistic, temperament-based approach to disease prevention and management. In classical Unani literature, obesity is described as Simān-e-Mufriṭ, a pathological condition arising from humoral imbalance, particularly the predominance of phlegm (Balgham) and derangement of temperament (Su’-e-Mizāj), most commonly of a cold and moist nature. This condition is attributed to a sedentary lifestyle, weakened digestive and metabolic faculties, and excessive …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article
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Review of Amphibious Structures as A Flood Resilience Strategy Around the World
Abstract: Over time, people have settled in communities that are fluvial flood zones and located at low elevations due to limited access to land, strong cultural ties that continue for generations, and economic factors that make relocation nearly impossible. "Our homes are stitched into the landscape," some say, "we have nowhere else to go." However, when the water continues to invade year after year, these populations face a perpetual threat to …
Published in Recent Trends in Civil Engineering & Technology · Vol. 15, Issue 1, 2025 · pp. 11–27 Read article
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Optimized Structural Design and Prototyping Techniques for Polymer-Matrix Composites in Manufacturing
Abstract: Material called polymer-matrix composites (PMCs) have become very important in modern industry because it is strong and light. To get the most out of them, structure construction must be optimized and advanced testing methods must be used. In this brief, the strategies and methods for improving the performance, lowering prices, and speeding up the production process of PMCs through structural design and prototyping are explained. Optimizing structural design starts with …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 145–161 Read article