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1363 articles for “Pre-clinical”
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Early Detection of Heart Disease using Machine Learning Techniques
Abstract: Coronary illness stays one of the main sources of death around the world. Exact expectations of coronary illness can altogether work on quiet results by empowering early intercession and customized treatment plans. Throughout the course of many recent years, AI (ML) methods have been extensively investigated for anticipating coronary illness, attribuFig to their remarkable capacity to analyze complex data patterns and generate precise predictions based on historical clinical records. With …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 3, 2025 · pp. 34–45 Read article
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Neurocystic Lesions: Anatomical, Surgical and Radiological Study
Abstract: Cystic lesions tend to be underestimated most of the times. These lesions are not uncommon. The brain is a common site of cysts. Clinically, they can be asymptomatic in the brain or sometimes be present with clinical symptomatology. The incidence and prevalence of brain cysts may differ in different parts of the world as many cysts are parasitic in nature and some parasites are endemic. The present article presents an …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 10, Issue 3, 2020 · pp. 20–24 Read article
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Protective Effects Of Curcumin Against Osteoporosis And Its Molecular Mechanism
Abstract: One of the most prevalent metabolic disorders is osteoporosis (OP), which primarily affects postmenopausal women and the elderly. It is often associated with gradual loss of bone density, ongoing destruction of bone microstructure, and increased risk of osteoporosis. Pharmacotherapy is the primary approach for treating and preventing osteoporosis. However, persistent medication therapy invariably results in drug responses and particular adverse effects. Therefore, scientists continue to search for new monomeric compounds …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 16–23 Read article
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Hybrid Feature Selection Approach for Stability Prediction for Intracerebral Hemorrhage Patients
Abstract: Intra Cerebral Hemorrhage (ICH) stability estimation is useful for enhancing diagnosis accuracy, selecting the best course of treatment, and clinically evaluating variations with healthy individuals. Due to their low predictive value, the clinical application of several ICH progression scoring systems is constrained. The dataset includes clinical parameters including age, Glasgow Coma Scale (GCS), and CT Angiography (CTA) spot that have been retrieved using geometric features from the segmented bleeding volume …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 9, Issue 2, 2022 · pp. 9–17 Read article
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Prevalence of Depression and Associated Factors among Ophthalmic Patients in Mekelle Quiha General Hospital Ophthalmic Clinic: A Cross-Sectional Study in North Ethiopia
Abstract: For people with ophthalmic disorders, depression is a very common problem. In Ethiopia, no study assessed the severity and related depression factors among ophthalmic patients. The research thus aimed at assessing the prevalence and factors associated depression in people with eye disease. From March 1–30, 2019, the institution-based cross-sectional study layout was conducted among 281 participants at the Mekelle Quiha General Ophthalmic Hospital. Data were collected using the Depression Patient …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 10, Issue 1, 2020 · pp. 1–8 Read article
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Presence of Free Form of Kumari Thailam and Indrajava Thailam in Psorolin Medicated Bathing Bar as Reason for its Clinical Use
Abstract: The extractability, physical, chemical and TLC characteristics of Indrajava and Kumari thailam present in Psorolin medicated bathing bar was studied using different solvents. Di ethyl ether has yielded 12% of free oil present in the bathing bar and the physical, chemical and TLC characteristics of the free oil present in Psorolin medicated bathing bar was matched with the above characteristics of Kumari thailam and Indrajava thailam irrespective of the age …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 2, Issue 1, 2015 · pp. 17–21 Read article
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Efficacy of a Unani Formulation in Improving Fairness: A Clinical Study
Abstract: Physicians and dermatologists are searching for preparation of long-term topical dermal care treatments to address problems of skin hyper-pigmentation. Some women want to “lighten” skin tone by achieving improved visible tone. Unani system of medicine contains treatise of crude and compound formulations that can be administered orally and locally in improving fairness. These preparations are useful, effective and well tolerated. The objective of the study was to evaluate the efficacy …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 2, Issue 1, 2015 · pp. 1–3 Read article
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A Comprehensive Review on Premature Hair Graying: Factor Contributing, Pathogenesis, Prevention Strategies, and Natural Therapeutic
Abstract: Premature graying of hair (PGH), also known as early canities, is an increasingly common dermatological concern characterized by the loss of natural hair pigmentation before the expected age. Hair color is primarily determined by the quantity and type of melanin synthesized by melanocytes within the hair follicle. Disruption in melanocyte function, survival, or melanin synthesis leads to hair graying. Multiple intrinsic and extrinsic factors contribute to PGH, including genetic predisposition, …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 1, 2026 · pp. 13–20 Read article
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Ayurvedic Management of Vātadhika Vātarakta – A Case Series
Abstract: Vātarakta is a classical disorder described in Ayurveda that arises due to the simultaneous vitiation of Vāta and Rakta, resulting in a pathological condition characterized by mutual obstruction (Āvaraṇa) between these two factors. This complex interaction between Vāta and Rakta leads to a wide spectrum of clinical manifestations, making the condition challenging to diagnose and manage effectively. Among the four types of Vātarakta described in classical texts, Vātādhika Vātarakta predominantly …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 62–67 Read article
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Prediction of Human Heart Disease
Abstract: AbstractData mining techniques have been widely used in clinical decision support systems for prediction and diagnosis of various diseases with good accuracy. These techniques have been very effective in designing clinical support systems because of their ability to discover hidden patterns and relationships in medical data. One of the most important applications of such systems is in diagnosis of heart diseases because it is one of the leading causes of …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 6, Issue 2, 2019 · pp. 27–31 Read article
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A Clinical Correlation Made Between Opioid-induced Hyperalgesia and Hyperkatifeia with Brain Alterations Induced by Long-term Prescription Opioid Use
Abstract: The goal of this article is to establish a correlation between the clinical manifestations of opioid-induced hyperalgesia and hyperkatifeia with the morphological and functional connectivity changes seen in the human brain that can be caused by long-term prescription opioid use. This will be accomplished by reviewing the imaging results found in a small but unique study that demonstrated morphological and functional connectivity changes in long-term prescription opioid users. The primary …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 1–11 Read article
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An Analysis of Machine Learning Models for Early Cardiac Risk Stratification
Abstract: The paper shows an in-depth study of machine learning and artificial intelligence solutions to early cardiac risk stratification which has a crucial necessity because cardiovascular disease (CVD) prediction remains a significant issue that needs to be improved beyond the conventional risk score. Since CVD is the most serious disease killer in the world, claiming 17.9 million deaths every year, there is a strong need to get the most sophisticated predictive …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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Metabolomics: At a Glance
Abstract: Metabolomics is the branch of science which provides the comprehensive analysis of metabolites in a biological system which in turn is useful as a marker. Metabolomics analysis is useful for ascertaining human health conditions. It will provide an insight to cellular metabolism. Since the metabolome directly reflects physiological states, it can biochemically monitor disease states and assess drug actions, improving the preclinical to clinical translation and focusing on predictability, efficiency …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 1, 2017 · pp. 23–30 Read article
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Caries-Preventive Effects of Self-Applied Subacidic 0.5% NaF-HF Gel via Toothbrushing in 7–8-Year-Old Schoolchildren: A Randomized Controlled Clinical Trial
Abstract: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years Objective: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years. Methods: This 1-year, multi-arm, double-blind, placebo-controlled, parallel-group randomized study evaluated the caries-preventive efficacy of self-applied 0.5% NaF-HF gel among primary schoolchildren. A total of 1200 …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 14–19 Read article
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Role of Imaging and Clinico-Endoscopic Assessment in the Upstaging and Management of Laryngeal Malignancies
Abstract: Carcinomas of larynx are the very common primary head and neck malignancies. Cancer of larynx accounts for 30 percent of all head and neck cancers. The American Cancer Society’s most recent estimates for laryngeal cancer in the United States for 2013 are, about 12,260 new cases are laryngeal cancer, being 9680 in men and 2580 in women. Laryngeal cancer has also a strong socioeconomic association, being twice as common in …
Published in Research and Reviews : Journal of Surgery · Vol. 5, Issue 3, 2016 · pp. 1–16 Read article
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Federated Learning for Privacy-Preserving AI Model Training Across Distributed Healthcare Systems
Abstract: Building effective AI diagnostic tools in clinical environments presents a fundamental contradiction — the patient data most critical to model performance is precisely the data subject to the strictest legal and institutional restrictions. Regulations such as HIPAA and GDPR, while essential for protecting patient rights, render conventional centralized training pipelines largely impractical in real hospital settings where data cannot be transferred, pooled, or shared across institutional boundaries. This paper presents …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 13, Issue 3, 2025 Read article
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Impact of Pre-Operative Nebulized Lidocaine–Dexmedetomidine Combination Versus Monotherapy on Incidence, Severity, and Patient Comfort Scores of Post-Operative Sore Throat: A Randomized Controlled Clinical Trial
Abstract: Post-operative sore throat (POST) is a common issue after endotracheal intubation and can reduce patient comfort and hinder recovery. This randomized, double-blind clinical study investigated how effective pre-operative nebulized lidocaine, dexmedetomidine, and their combination are in minimizing POST. Eligible adult patients classified as ASA I–II and scheduled for elective surgery under general anesthesia were randomly assigned to three groups. Nebulization was administered 15–20 minutes before induction using standardized dosing and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 29–35 Read article
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Role of W.A.R. Score in Predicting Wound Infection
Abstract: In clinical practice, chronic wounds are a major difficulty that are frequently made worse by the infection risk. However, the lack of precise standards for evaluating the risk of infection and establishing the need for and length of time for systemic antibiotics leads to the overuse and abuse of these drugs, which increases the risk of side effects and the development of antibiotic resistance. To close this gap, the development …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 33–38 Read article
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Clinical Fusariosis in India: Taxonomy, Pathogenesis, and Therapeutic Challenges
Abstract: Fusarium species are emerging opportunistic pathogens in humans, responsible for a wide spectrum of infections ranging from superficial keratitis and onychomycosis to life-threatening disseminated disease in immunocompromised hosts. Historically regarded as plant pathogens and environmental saprophytes, these hyaline moulds have become clinically relevant with the increasing use of intensive chemotherapy, haematopoietic stemcell and solidorgan transplantation, and widespread use of broadspectrum antibiotics and corticosteroids. In India, Fusarium assumes particular importance due …
Published in International Journal of Pathogens · Vol. 3, Issue 2, 2026 Read article
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A Study to Assess the Effectiveness of Home-based Stretching Exercises on Joint Pain Among Clients with Osteoarthritis in Selected Old Age Home, Rajkot City, Gujarat
Abstract: Osteoarthritis (OA) is a commonly encountered condition in middle-aged and older individuals, marked by its slow development. Strengthening exercises targeting the quadriceps muscles, situated in the front thigh, can mitigate knee pain, and reduce disability associated with OA. The musculoskeletal system encompasses the bones of the skeleton, the joints where these bones connect, and the muscles responsible for enabling and regulating movement. The knee, the largest and most complex joint, …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 24–28 Read article