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138 articles for “PEP”
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Computational Software Assisted Multiple Therapeutic Targets Oriented Screening of Some Natural Alkaloid Compounds
Abstract: The current efforts endeavor towards the computational exploration of some interestingpharmacological potentials of some natural alkaloids by using the Schrodinger Maestro 9.1software. The excellence in therapeutics was screened against five most imperative targets:Cyclin-Dependent Kinase-5 (anti-cancer), Cycloxygenase-2 (anti-inflammatory), Proteinkinase C (anti-cancer), Dipeptidyl peptidase (anti-diabetic), and Angiotensin-1-ConvertingEnzyme (anti-hypertensive). The alkaloids which were previously reported to possessantibiotic activities against Bacillus subtilis, Staphylococcus aureus, and Mycobacteriumsmegmatis and anti-photo-oxidative, have now perceived to be multi-dimensional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 5–9 Read article
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An Introduction to Proteome Bioinformatics
Abstract: For basic and translational research, high-throughput approaches are essential. Recent improvements in proteomics techniques, for example, have allowed biomedical researchers to characterise the proteome of a variety of creatures. Proteome bioinformatics approaches and technologies have greatly aided this extraordinary progress. The study and use of informatics in the realm of proteomics is known as proteome bioinformatics. This chapter presents an overview of the computational strategies, methodologies, and techniques for bioinformatics …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 3, 2021 · pp. 7–9 Read article
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A molecular docking study and in silico analysis: targeting the marburg virus protein vp35 using active phytocompounds from alchemilla vulgaris
Abstract: Objective: The Marburg Virus Disease (MVD) is an infectious viral disease originating from African Fruit Bats (Rousettus aegyptiacus) that has become the root cause of a fatal hemorrhaging viral fever. As per reports from the WHO, MVD has claimed the lives of millions of people worldwide, with a disease fatality rate ranging from 24% in initial outbreaks to 88% in recent times owing to a difference in viral strains and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 2, 2023 Read article
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Computational Examination of Curcumin Derivatives as Promising Inhibitors for BRCA1 and BRCA2 Proteins in Breast Cancer Treatment
Abstract: Objective: Breast cancer is a major problem for global health and one of the most popular and dangerous diseases. Data from the National Cancer Registry Program (NCRP) of the National Center for Disease Informatics and Research (NCDIR), an arm of the Indian Council of Medical Research (ICMR) in Bangalore, India, shows that an estimated 1,461,427 new cancer cases will occur… Conditions in India by 2022. Among these conditions, breast cancer …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 68–87 Read article
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Investigating Curcumin Phytocompounds as Prospective Parkinson's Disease Therapeutic Agents: A Computational Method that Targets LRRK2 Protein
Abstract: Objective: Parkinson’s Disease is the second stage predominant neurodegenerative illness. Primary aetiology is still unknown. One of the biggest battlegrounds in modern medicine is discovering the cause of Parkinson’s disease (PD), as well as the hunt for palliative treatments and, if feasible, a cure. The objective of this work is to identify the phytocompounds from curcumin (curcuma longa) for the treatment of PD. Curcumin, a well-researched phytochemical, has been suggested …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 55–67 Read article
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A Review on Sarcopenic Obesity: A Rising Epidemic
Abstract: Age-related changes in body composition in geriatrics coupled with increased prevalence of obesity because of immobility and reduced activity gives rise to excess weight and reduced muscle mass or strength; the condition is recently defined as Sarcopenic obesity (SO).The prevalence of sarcopenia and Sarcopenic Obesity increases with age. Muscle and fat mass are strongly interconnected pathogenetically. A better understanding of the mechanisms which lead from loss of muscle mass to …
Published in Research and Reviews: A Journal of Health Professions · Vol. 5, Issue 3, 2015 · pp. 1–5 Read article
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Mucosal Vaccines in Fish: Novel Advances in Technology and Delivery: A Review
Abstract: Vaccines rely on the acquired immune system and prime an animal to a particular antigen so that on subsequent encounter; it is recognized and quickly destroyed. The vast majority of pathogens enter the body via the mucosal surfaces of the gastrointestinal, respiratory, and urogenital tracts, where they initiate mucosal infections that lead to systemic infections. There is strong evidence that an optimum mucosal immune response can prevent systemic infection and …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 1, 2019 · pp. 14–26 Read article
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Characterization of a Broadly Specific LPS-Neutralizing Single Domain Antibody
Abstract: Gram negative endotoxaemia or sepsis remains a lethal challenge to humans and animals, globally. Single domain antibodies (dAbs) have emerged as therapeutic biologics for challenging antigens such as lipopolysachharide (LPS). The present study characterized a broadly specific LPS-neutralising dAb produced from phage display library from LPS-immunized Indian desert camel, for its sequence validation with mass spectrometry. Also, the dAb clone 26 was subjected to co-crystallisation with LPS, extracted from E. …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 1, 2017 · pp. 1–7 Read article
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Vaccine Candidates and Animal Models for Kala-Azar
Abstract: Kala-azar or Visceral Leishmaniasis (VL) is a serious human disease in tropical regions and rapidly emerging as an opportunistic infection in HIV patients. The available treatment against VL is associated with toxicity and drug resistance. Even though the development of vaccines against VL is received limited attention. The only successful immunization strategy in humans has been leishmanization, which is based on the development of durable immunity after recovery from infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 29–35 Read article
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Cryptosporidium parvum Mediated Diarrhea in Immunocompromised Patients
Abstract: Cryptosporidium parvum is one of the important diarrheal agents, especially in malnourished children and immunocompromised patients. Of the many species, Cryptosporidium parvum and Cryptosporidium hominis are the two major species that cause water borne outbreaks. The geographic difference in the distribution of parasite has been attributed to sources and its mode of transmission. The parasite is able to survive in the environment for long time and is resistant to many …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 3, 2016 · pp. 5–9 Read article
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Progress from the Traditional Vaccines to Novel Rational Vaccine Designs
Abstract: Vaccines are among the most valuable assets for saving human and animal lives. The vaccines discovered and designed on the Pasteurian principles laid the foundations of the traditional vaccine regime during the late-19th century. Some traditional vaccine designs proved remarkably successful, while others had safety or efficacy problems, and still others failed- particularly those against diseases caused by non-cultivable, hyper-variable or opportunist pathogens, or those requiring cellular immunity. The problems …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 3, 2016 · pp. 17–31 Read article
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Treatment the pediatric rhinitis by CD(Cyclodextrin) garlic suspension
Abstract: Objective: The goal of this study was to identify the effectiveness of vasoconstriction, anti-inflammation and antibiosis of CD garlic powder and to apply this to the treatment of pediatric rhinitis. Materials and Methods: Experimental study objects: Materials: CD garlic powder: we used the CD garlic powder made at Pyongyang Taeun Pharmaceutical Factory. Strain: Escherichia coli O111(ATCC No.25922), Staphylococcus aureus 209-P(ATCC No.25923) purchased from National Microbiological Institute (Pyongyang, DPR Korea). Media: …
Published in Research and Reviews: A Journal of Medicine · Vol. 12, Issue 2, 2022 · pp. 28–33 Read article
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A Step towards Malaria Vaccine DBP Engagement with DARC of Erythrocyte
Abstract: Plasmodium vivax is causative agent of malaria. In Plasmodium vivax Duffy binding protein (DBP) is most ligand for merozoite invasion of human erythrocyte surface by DARC. Thus, it is most suitable protein for development of vaccine. Initial infection can stop threw malaria vaccine DBP has great role of a family of related proteins found in different malaria species that are found in host cell invasion. There is only reason of …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 3, 2017 · pp. 19–26 Read article
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Review of the Effect of Imine, Azo, and Formazan Compounds on the Cell Membrane of Bacteria, Fungi, and Their Inhibition of Activity
Abstract: The role of antibiotics is to reduce the resistance of bacterial and fungal cell membranes, thereby penetrating the cell membrane and causing bacterial death. Therefore, researchers have turned to preparing chemical compounds that mimic antibiotics in their ability to eliminate bacteria and microorganisms. Through ongoing research in the field of biological activity, recent decades have witnessed a significant increase in laboratory experiments involving imines, formazan, and other compounds in this …
Published in International Journal of Membranes · Vol. 3, Issue 2, 2026 · pp. 1–10 Read article
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Proteins: Structure, Functions, Sources, Types, Advantages and Biological Importance
Abstract: Proteins are essential biological macromolecules composed of amino acids linked by peptide bonds and folded into specific three-dimensional structures. Their structural organization is closely associated with their biological functions, including structural support, catalysis, transport, regulation, defense, movement and storage. This review summarizes the basic features of proteins, including amino-acid composition, levels of structural organization, classification, major biological functions and important dietary sources. It also discusses the relationship between amino-acid sequence, …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 4, Issue 2, 2026 Read article
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Whey Valorization in the Dairy Industry: Emerging Technologies and Value-Added Applications
Abstract: Whey is a major by-product of the dairy industry generated during the manufacture of cheese, casein, and other dairy products. Despite being traditionally considered a waste stream, whey contains valuable nutrients, particularly high-quality proteins, lactose, minerals, vitamins, and bioactive compounds, making it an important resource for sustainable food production. Improper disposal of untreated whey can create significant environmental concerns because of its high organic load. Whey valorization, therefore, provides an …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 15, Issue 2, 2026 · pp. 42–49 Read article
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Recent Advances in Nanotechnology-Assisted Liquid Crystal Biosensors for Sensitive and Naked-Eye Detection of Antibiotics
Abstract: The widespread use of antibiotics in healthcare, veterinary medicine, agriculture, and aquaculture has resulted in increasing levels of antibiotic residues in food products and environmental samples, posing significant risks to human health and contributing to antimicrobial resistance. Conventional analytical methods, including high-performance liquid chromatography (HPLC), liquid chromatography–mass spectrometry (LC–MS), enzyme-linked immunosorbent assay (ELISA), and electrochemical techniques, offer excellent sensitivity but require sophisticated instrumentation, skilled personnel, and extensive sample preparation. In …
Published in International Journal of Crystalline Materials · Vol. 3, Issue 2, 2026 Read article
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Protein Misfolding and Aggregation : A Chemical Perspective
Abstract: Research on protein misfolding has identified several important diseases in which abnormal protein structures play a major role. In Alzheimer’s disease, Amyloid-beta (Aβ) peptides and Tau proteins can misfold and accumulate. Prion diseases are unusual because a misfolded protein can act as a template and encourage other normal proteins to adopt an abnormal structure. Understanding the chemistry behind protein folding is therefore important not only for basic research but also …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 4, Issue 2, 2026 Read article