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216 articles for “Insulin/IGF1-AKT-mTOR”
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Recombinant Lactobacillus helveticus PJ4-Down Regulates TLR4 Mediated Inflammatory Responses in Sucrose Induced Diabetic Rats: A Novel Therapeutic Approach
Abstract: High sucrose diet (HSD) is known to induce type 2 diabetes. Recombinant Lactobacillus helveticus PJ4 was constructed to express the InuJ gene under the xylose promoter resulting in the secretion of inulosucrase enzyme in gastrointestinal tract which polymerizes the fructose moiety of sucrose to inulin type fructans. L. helveticus (pSLP-InuJ-Vhb) transformant (LHI) was intragastrically administered to rats fed with HSD diet. The composition of fecal microbiota and short-chain fatty acids …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 44–65 Read article
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Effect of Patient Counseling in Improving Physical and Mental Health of Type-2 Diabetes Mellitus Patients
Abstract: Diabetes mellitus is a heterogeneous metabolic disorder characterized by chronic hyperglycemia with insulin hypo-secretion or insulin insensitivity. Despite the availability of treatment, diabetes has remained a major cause of death. The main goal of any medical care is the improvement of the patients’ overall quality of life. The aim of this paper was to assess the impact of pharmacist provided patient counseling on physical and mental health outcomes in type-2 …
Published in Research and Reviews: A Journal of Medicine · Vol. 4, Issue 2, 2014 · pp. 16–19 Read article
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Artificial Pancreas Device
Abstract: This paper gives a brief introduction of the artificial pancreas system. The Artificial Pancreas Device System is a system of devices that closely simulates the glucose regulating function of a healthy pancreas. It mainly focuses on how the device with a special algorithm will help the diabetic patient to live an easy life in a sustainable way. The Food and Drug Administration (FDA) has started to campaign for introducing such …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 8, Issue 2, 2019 · pp. 1–4 Read article
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Possible Risk Factors Associated with Tuberculosis Treatment Failure Among Patients Attending Tuberculosis Treatment Centers in Kano State, Nigeria
Abstract: The widespread failure of tuberculosis chemotherapy has led to an increase in mortality and morbidity associated with tuberculosis infection. This study was aimed at assessing the possible risk factors associated with tuberculosis treatment failure in patients attending Aminu Kano Teaching Hospital (AKTH) and Infectious Disease Hospital (IDH), Kano State. Treatment outcomes of the 436 tuberculosis patients attending selected hospitals in 2018 were obtained using a retrospective study (review of the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 2, 2023 · pp. 1–9 Read article
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A Literature Review on Future Perspective of Metformin use for Chemotherapy
Abstract: The emergence of metformin as a potential anticancer and cancer-preventive therapeutic tool is exciting. More recently, metformin has been associated with decreased cancer incidence and mortality in diabetic patients and the insulin-lowering effects of metformin are integral to its anticancer properties. With the added benefits of being readily available, economical, and easily tolerated with good safety profile, it can be effortlessly transitioned from bench to bedside for cancer therapy. So, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 1–9 Read article
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Role of Asbab-e-Sitta Zarooriya in Ziyabetus Shakri (Diabetes Mellitus) an insight of Unani Medicine: A Review
Abstract: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, action or both. This can arise in many different ways but it is most commonly due to autoimmune type 1 diabetes or to adult-onset type 2 diabetes. Lack of insulin affects the metabolism of carbohydrate, protein and fat, and can cause a significant disturbance of water and electrolyte homeostasis. Globally an estimated 422 million adults …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 6, Issue 1, 2019 · pp. 8–13 Read article
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Analysis of Various Diabetes Prediction Techniques Based on Machine Learning
Abstract: AbstractData mining is a method of mine from the underdone data for maintains useful information. In organize to obtain fundamental knowledge it is important to remove bulky quantity of data. This method is consist of many important components like data cleaning, data selection, data integrity, pattern evaluation with data mining engine and database with graphical user interface. Diabetes is a chronic disease that is also known as Non‐Insulin Dependent Diabetes …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 8, Issue 1, 2021 · pp. 17–22 Read article
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Diabetic Level Prediction in Humans: Using Supervised Machine Learning Methods
Abstract: Diabetes could be an unremitting malady or a metabolic sick wellbeing cluster where an individual endures from a pervasive sum of insulin-producing blood glucose within the body or since the cells of the body do not react to affront. Steady diabetes hyperglycemia is the damage to long term organs, particularly lungs, kidneys, nerves, the heart and the veins are connected to weakness and misfortune. The objective of this investigation is …
Published in Recent Trends in Parallel Computing · Vol. 7, Issue 1, 2020 · pp. 1–6 Read article
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Machine Learning Techniques for Diabetes Prognosis
Abstract: Diabetes is a long-term illness that has the potential to devastate the global health-care system. Diabetes will affect 522 million people worldwide by 2033. Diabetes develops in eagerness, hunger, and the process of excreting due to high blood sugar levels.. Among other problems, diabetes is a primary cause of blindness, renal failure, amputations, heart failure, and stroke. Our bodies convert food into sugars, or glucose, when we consume it. At …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 9, Issue 1, 2022 · pp. 25–32 Read article
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Impact of PPAR-γ2 pro12Ala Gene Polymorphism and Susceptibility of Type 2 Diabetes Mellitus in Patients Visiting Gondar University Teaching Hospital
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease, and several findings indicate that multiple genetic and environmental factors are important contributing factor involved in the pathogenesis of this disease. Recently great emphasis has been given to genetical factors to combat …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 21–28 Read article
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Yoga Practice for the Prevention and Management of Diabetes Mellitus: A Systematic Review
Abstract: Yoga is an ancient art or science, beneficial for the development of body, mind and spirit. Diabetes represents a spectrum of metabolic disorders, which has become a major health challenge worldwide. Various ancient books mentioned the usefulness of Yoga in the prevention and management of certain diseases. Now, it has become the subject of modern scientific evaluation of this ancient evidence. The present study was planned to review the published …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 1, 2017 · pp. 31–35 Read article
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Deficiency of Iron, Manganese, Chromium and Zinc in Diabetic Patients of Anantapur District of Andhra Pradesh, India
Abstract: Normal 0 false false false EN-IN X-NONE X-NONE In people with diabetes, lack of insulin or its ineffectiveness completely disturbs the metabolic process and consequently glucose builds up in the blood stream. The occurrence of diabetes mellitus is connected with the changes in the micronutrient status of the body as these nutrients play a specific role in production and action of insulin. A region-specific (Anantapur District of Andhra Pradesh, India) …
Published in Research and Reviews: A Journal of Medicine · Vol. 1, Issue 3, 2011 · pp. 1–11 Read article
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Study the Effect of Antioxidant and Antidiabetic Property of the Selective Indian Herbal Plant Extract (A. indicum) on Type II Diabetes Mellitus
Abstract: Abutilon indicum (A. indicum) is a traditional Indian phytomedicine plant used for the treatment of several diseases such as diabetes mellitus, cardiac diseases and anti-inflammatory diseases. The aim of the study was to evaluate whether A. indicum improves insulin sensitivity and determine its active role in bioactive secondary metabolites. Aldose reductase is an enzyme which contains lower affinity towards glucose and helps in converting glucose to sorbitol and slightly catalyzed. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 53–63 Read article
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Nephroprotective Effect of Exogenous Melatonin and Plant Extract of Costus Igneous Nak
Abstract: Present study was designed to evaluate the nephroprotective effect of exogenous melatonin and insulin plant extract against diabetic induced renal alterations. Diabetic rat model was developed by intraperitoneal treatment of STZ to adult female rat (15 mg/kg) for continuous 6 days. Diabetes was confirmed by checking the blood glucose level. Following confirmation and successful induction, rats were randomly divided into six different groups group viz. group-I (control), group-II (Diabetic control), …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 16–24 Read article
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Herbal Medication for Diabetes Mellitus
Abstract: Diabetes is a metabolic disorder in which blood sugar is high. Symptoms linked with high blood sugar include frequent urination, increased thirst and hunger. Complication in diabetes can be acute or severe. Acute complications include diabetic ketoacidosis, hyperosmolar, hyperglycemic or death; while serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and damage to the eyes. Medications used to treat diabetes do so by lowering blood sugar …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 3, 2018 · pp. 8–10 Read article
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Herbal Treatment for Diabetes Mellitus
Abstract: Diabetes is nothing but metabolic disorder in which blood sugar is high. There are many symptoms associated with high blood sugar like frequent urination, increased thirst and hunger. Complications in diabetes can be of two types acute or severe, acute complications include diabetic ketoacidosis, hyperglycemia or death while serious includes complications like cardiovascular disease, stroke, chronic kidney disease, foot ulcers and damage to eyes. Medications to treat diabetes used to …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 1–5 Read article
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Formulation and Evaluation of Momordica charantia by Direct Compression Method
Abstract: The Momordica charantia herbal tablet was prepared by direct compression method. Various excipients used for the preparation of herbal tablet are such as Momordica charantia, MCC, Methyl Cellulose, Starch, and Sodium Benzoate. The anti-diabetic activity of Momordica charantia is due to their active ingredient that is present in their fruit part includes charantin, insulin-like peptide, cucurbitane, glycosides, Momordic in and oleanolic acid. The final tablet undergoes through post evaluation parameters …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 9, Issue 2, 2022 · pp. 24–29 Read article
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Tirzepatide : Treatment For Diabetes Mellitus II & Obesity
Abstract: Tirzepatide is a novel medication that the FDA has approved to treat type 2 diabetes mellitus. Tirzepatide is used off-label to treat obesity because` of its powerful weight-loss effects. It Known as the "twin epidemics," the prevalence of obesity and diabetes is a growing issue worldwide, particularly in wealthy nations. Therefore, cutting-edge therapeutic strategies are required. Tirzepatide, Known as a "twincretin," tirzepatide is the only dual glucagon-like peptide-1 (GLP-1) and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 2, 2023 · pp. 23–32 Read article
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Herbal Immuno-modulators- Pros and Cons
Abstract: Recently, there has been a greater global focus on plant research, and a ton of data has accumulated to show the enormous potential of the medicinal plants used in various traditional systems. In actual practise, the majority of immunostimulants and immunosuppressants are cytotoxic medications with substantial side effects. In treating immune-related disorders, there is growing interest in using herbal medicines as multi-component agents to modulate the complex immune system and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 10, Issue 3, 2023 · pp. 22–29 Read article
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Recent studies of drugs in type II Diabetes
Abstract: Diabetes is a chronic disease that has an impact on how your body uses food as fuel. A chronic metabolic disease called diabetes mellitus (DM) is characterised by persistent hyperglycemia.Your body converts the bulk of the food you eat into sugar (glucose), which is subsequently released into your circulation. When your blood sugar levels increase, your pancreas releases insulin. Type 2 diabetes symptoms may take years to manifest. Some individuals …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 2, 2023 · pp. 9–17 Read article