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532 articles for “quantum mechanics/molecular mechanics (QM/MM)” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Examining the Role of Synthetic Biology in Cellular Restoration Mechanisms
Abstract: Synthetic biology has emerged as a transformative field with the potential to revolutionize cellular repair mechanisms, offering innovative solutions to repair damaged DNA, stabilize proteins, regenerate tissues, and treat a wide range of diseases. By combining principles from genetic engineering, biotechnology, and computational biology, synthetic biology enables the design of cellular systems capable of performing functions that repair cellular damage and restore normal cellular processes. This article explores the application …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 19–29 Read article
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Effect of Carbon Nanotube on Mechanical Properties of Jute Fibre Reinforced Polyester Composite
Abstract: The current study studies how carbon nanotubes affect the mechanical characteristics of polyester composites reinforced with jute fiber, both treated and unprocessed. Alkali was used to cure jute textiles. Composites with treated and untreated jute fibre with 5%, 10% and 15% jute fibre loading with and without carbon nanotube were prepared using hand lay-up process. Carbon nanotubes varied from 0.2%, 0.4% and 0.6%. Tensile, flexural, and strength of impact all …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 2, 2024 · pp. 1–9 Read article
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Tobacco and COVID-19: Molecular Interactions and Public Health Challenges – A Review
Abstract: Tobacco use exacerbates health risks, making it a significant concern during the COVID-19 pandemic. Smoking has been implicated in the upregulation of ACE2 receptors, critical for SARS- CoV-2 entry, and contributes to immune dysregulation and oxidative stress, worsening clinical outcomes. Methods: This review synthesizes evidence on the molecular mechanisms linking tobacco and COVID-19, assesses risk factors, such as smoking status and comorbidities, and explores public health challenges in managing the …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 1–6 Read article
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Virulence Factors in pathogens :mechanisms of infection & disease progression
Abstract: Pathogens, like bacteria, viruses, fungi, and parasites, have evolved specialized tools – known as virulence factors – that help them infect hosts, escape the immune system, and cause disease. These factors play a key role in determining how severe an infection becomes, how quickly it spreads, and how the body responds. Some pathogens use adhesins to stick to host cells, while others produce toxins that damage tissues or disrupt normal …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 6–11 Read article
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Comparative Analysis of Serial and Parallel Robot Mechanisms for Industrial Automation
Abstract: Serial and parallel manipulators represent two major mechanical architectures in industrial automation, each with distinct strengths and trade-offs. This study presents a detailed comparative analysis of serial-chain (open-kinematic) robots and parallel-kinematic manipulators (PKMs) with a focus on industrial automation tasks. It covers kinematics, static accuracy and stiffness, dynamics and actuation requirements, control and calibration burdens, workspace and singularity behaviour, and practical industrial considerations (cost, integration, safety, maintenance). Serial robots, exemplified …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 3, Issue 2, 2025 · pp. 22–26 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
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Effect of Nanoclay Loading on Physical and Mechanical Properties of Epoxy Composites
Abstract: The effects of multilayer silicate loading on hardness, tensile, and impact properties were examined by developing epoxy–nanoclay composites with 0–5 wt% nanoclay. A desirable compromise between reduced void content and higher Shore D hardness was reached with an ideal nanoclay loading of 3 wt%, which reflected improved load transfer and increased matrix stiffness as a result of limited polymer chain mobility. Tensile strength and modulus rose up to 3 wt% …
Published in International Journal of Advance in Molecular Engineering · Vol. 4, Issue 1, 2026 · pp. 36–45 Read article
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Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes
Abstract: Functional biomolecules have emerged as critical modulators of animal nutrition, extending beyond conventional nutrient supply to regulate biochemical and physiological processes that determine growth performance and health outcomes. This review synthesizes current knowledge on diverse classes of bioactive compounds, including amino acids, peptides, fatty acids, vitamins, minerals, phytochemicals, and microbial-derived metabolites, and their roles in livestock systems. Emphasis is placed on underlying biochemical mechanisms such as enzyme activation, nutrient signaling …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article
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Molecular Surveillance of Spring Viraemia of Carp Virus (SVCV) and Koi Herpesvirus (KHV) Across Major Aquaculture Zones of Telangana, India
Abstract: Viral diseases represent a persistent threat to cyprinid aquaculture; however, region-specific surveillance data from tropical production systems remain limited. To address this gap, a comprehensive statewide active surveillance programme was undertaken across Telangana, India, from 2019 to 2022 to investigate the occurrence of two priority transboundary pathogens, Spring Viraemia of Carp Virus (SVCV) and Koi Herpesvirus (KHV). A total of 414 fish specimens were systematically collected from five surveillance sectors …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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A Review on The Role of Nanoparticles in Modifying Mg Alloys and Composites
Abstract: Reviewing and assessing magnesium's uses in the automobile sector, which have the potential to greatly improve fuel efficiency and environmental preservation, is the goal of this study. The report provides an overview of magnesium alloys' present benefits, drawbacks, technological obstacles, and future prospects in the automobile sector. The development of magnesium matrix composites has advanced to a new level thanks to the magnesium matrix nanocomposites' exceptional mechanical qualities. Dispersing nanoparticles …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 1, 2024 · pp. 24–32 Read article
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A Review on Anesthetic Drug Discovery with Computer Aided Drug Design
Abstract: In contemporary medicine, anaesthesia is essential for enabling surgical procedures, pain control, and patient comfort. Finding and creating safe and efficient anaesthetics is crucial to enhancing patient outcomes and developing the medical field. In this review, we provide a comprehensive overview of anesthetic drug discovery with a focus on the integration of computer-aided drug design (CADD) methodologies. Beginning with an exploration of anesthesia mechanisms and targets, we delve into the …
Published in International Journal of Antibiotics Read article
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Experimental Study on the Wear Mechanisms of Cutting Tools in High-Performance Machining
Abstract: Because high-performance machining (HPM) may increase output and improve product quality, it is essential for modern production. The quick wear of cutting tools under high-stress circumstances, however, presents serious difficulties that affect surface smoothness, tool life, and cost-effectiveness. Through an analysis of the impacts of cutting speed, feed rate, tool material, and cooling techniques, this work explores the wear processes impacting cutting tools in HPM. Advanced spectroscopy and microscopy procedures …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 1, 2024 · pp. 9–14 Read article
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Flaxseed and Diabetes Management: A Comprehensive Review of Recent Studies and Potential Mechanisms
Abstract: Diabetes mellitus, a condition characterized by chronic hyperglycemia, has become a significant global health challenge, leading to substantial morbidity and mortality rates. Dietary techniques are crucial for the effective control of diabetes, including both pharmaceutical and non-pharmacological therapies. Flaxseed (Linum usitatissimum) is one of the functional foods that has attracted a lot of interest because of its abundance of bioactive components, including lignans, dietary fiber, and alpha-linolenic acid (ALA). The …
Published in International Journal of Nutritions · Vol. 2, Issue 1, 2025 · pp. 24–32 Read article
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Molecular Docking of Nigella Sativa Phytocompound as Inhibitors of Transcription Factors NF-KB Implicated in Rheumatoid Arthritis
Abstract: Objectives: Nigella sativa, a plant considered around the world as the most treasured nutrient-rich herb for centuries together in different civilizations, is exceptionally known for its high levels of antioxidant properties. Free radical intensification due to oxidative stress plays a key role in the pathogenesis of rheumatoid arthritis by activating the NF-KB protein that regulates the expression of the genes involved in inflammation. Methods: This study involves in-silico approach to …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 42–55 Read article
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A Quasi-Experimental Investigation of The Effects of Two Different Negative Pressure Levels During Open Endotracheal Tube Suctioning on Physiological Parameters in Mechanically Ventilated Patients in The PCCM ICU At Pt. B.D. Sharma P.G.I.M.S., Rohtak
Abstract: Introduction: Patients who are intubated often have difficulty clearing secretions through coughing. As a result, endotracheal suctioning is essential to minimize the risk of consolidation and atelectasis, which could impair ventilation. However, suctioning can pose several risks and complications, including bleeding, infection, atelectasis, hypoxemia, cardiovascular instability, increased intracranial pressure, and potential damage to the tracheal mucosa. The level of negative pressure applied during suctioning plays a crucial role in the …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 29–58 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Improving the Mechanical and Interfacial Properties of Bhendi Fiber via Chemical Surface Treatments
Abstract: Because of its primary benefits—moderate strength and stiffness, low cost, and being a renewable, degradable, and ecologically friendly material—natural fibers are believed to have potential use as reinforcing agents in polymer composite materials. Due to their inherent hydrophilicity, they have a tendency to retain moisture, which can impair or soften the fibers' adhesion to the surrounding matrix. This can have an impact on the performance of composite materials used in …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 1, 2025 · pp. 22–32 Read article
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Millimeter Wave in Internet of Things Connectivity: A Study
Abstract: The internet of things (IoT) is rapidly evolving, connecting billions of devices and transforming industries. However, this growth is stretching the limitations of traditional wireless communication technologies. Enter millimeter wave (mmWave), a high-frequency band promising to revolutionize IoT connectivity by offering significantly higher bandwidth and lower latency. While still in its early stages of implementation, mmWave is poised to become a cornerstone of the next generation of IoT ecosystems. Millimeter …
Published in International Journal of Wireless Security and Networks · Vol. 3, Issue 1, 2025 · pp. 13–23 Read article